Permeation Protection by Waterproofing Mucosal Membranes

<p>The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability</p><p>depends mainly on the thickness and keratinization degree of the tissues. Their permeability</p><p>barrier is conditioned by the presence of certain lipids. This w...

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Authors: Coderch Negra, Ma. Luisa, Alonso, Cristina, Calpena Campmany, Ana Cristina, Pérez García, M. Lluïsa (Maria Lluïsa), Clares Naveros, Beatriz, Ramos, Anderson, Martí, Meritxell
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/208111
Online Access:https://hdl.handle.net/2445/208111
Access Level:Open access
Keyword:Membrana mucosa
Mucosa gastrointestinal
Mucous membrane
Gastrointestinal mucosa
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spelling Permeation Protection by Waterproofing Mucosal MembranesCoderch Negra, Ma. LuisaAlonso, CristinaCalpena Campmany, Ana CristinaPérez García, M. Lluïsa (Maria Lluïsa)Clares Naveros, BeatrizRamos, AndersonMartí, MeritxellMembrana mucosaMucosa gastrointestinalMucous membraneGastrointestinal mucosa<p>The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability</p><p>depends mainly on the thickness and keratinization degree of the tissues. Their permeability</p><p>barrier is conditioned by the presence of certain lipids. This work has the main aim of reinforcing the</p><p>barrier effect of oral mucosa with a series of formulations to reduce permeation. Transmembrane</p><p>water loss of different formulations was evaluated, and three of them were selected to be tested on</p><p>the sublingual mucosa permeation of drugs. Caffeine, ibuprofen, dexamethasone, and ivermectin</p><p>were applied on porcine skin, mucosa, and modified mucosa in order to compare the effectiveness of</p><p>the formulations. A similar permeation profile was obtained in the different membranes: caffeine</p><p>> ibuprofen~dexamethasone > ivermectin. The most efficient formulation was a liposomal formulation</p><p>composed of lipids that are present in the skin stratum corneum. Impermeability provided</p><p>by this formulation was notable mainly for the low-molecular-weight compounds, decreasing their</p><p>permeability coefficient by between 40 and 80%. The reinforcement of the barrier function of mucosa</p><p>provides a reduction or prevention of the permeation of different actives, which could be extrapolated</p><p>to toxic compounds such as viruses, contaminants, toxins, etc.</p>MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/208111Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/https://doi.org/10.3390/pharmaceutics15122698Pharmaceutics, 2023, vol. 15, p. 2698https://doi.org/https://doi.org/10.3390/pharmaceutics15122698cc-by (c) Coderch, L. et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2081112026-05-27T06:46:51Z
dc.title.none.fl_str_mv Permeation Protection by Waterproofing Mucosal Membranes
title Permeation Protection by Waterproofing Mucosal Membranes
spellingShingle Permeation Protection by Waterproofing Mucosal Membranes
Coderch Negra, Ma. Luisa
Membrana mucosa
Mucosa gastrointestinal
Mucous membrane
Gastrointestinal mucosa
title_short Permeation Protection by Waterproofing Mucosal Membranes
title_full Permeation Protection by Waterproofing Mucosal Membranes
title_fullStr Permeation Protection by Waterproofing Mucosal Membranes
title_full_unstemmed Permeation Protection by Waterproofing Mucosal Membranes
title_sort Permeation Protection by Waterproofing Mucosal Membranes
dc.creator.none.fl_str_mv Coderch Negra, Ma. Luisa
Alonso, Cristina
Calpena Campmany, Ana Cristina
Pérez García, M. Lluïsa (Maria Lluïsa)
Clares Naveros, Beatriz
Ramos, Anderson
Martí, Meritxell
author Coderch Negra, Ma. Luisa
author_facet Coderch Negra, Ma. Luisa
Alonso, Cristina
Calpena Campmany, Ana Cristina
Pérez García, M. Lluïsa (Maria Lluïsa)
Clares Naveros, Beatriz
Ramos, Anderson
Martí, Meritxell
author_role author
author2 Alonso, Cristina
Calpena Campmany, Ana Cristina
Pérez García, M. Lluïsa (Maria Lluïsa)
Clares Naveros, Beatriz
Ramos, Anderson
Martí, Meritxell
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Membrana mucosa
Mucosa gastrointestinal
Mucous membrane
Gastrointestinal mucosa
topic Membrana mucosa
Mucosa gastrointestinal
Mucous membrane
Gastrointestinal mucosa
description <p>The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability</p><p>depends mainly on the thickness and keratinization degree of the tissues. Their permeability</p><p>barrier is conditioned by the presence of certain lipids. This work has the main aim of reinforcing the</p><p>barrier effect of oral mucosa with a series of formulations to reduce permeation. Transmembrane</p><p>water loss of different formulations was evaluated, and three of them were selected to be tested on</p><p>the sublingual mucosa permeation of drugs. Caffeine, ibuprofen, dexamethasone, and ivermectin</p><p>were applied on porcine skin, mucosa, and modified mucosa in order to compare the effectiveness of</p><p>the formulations. A similar permeation profile was obtained in the different membranes: caffeine</p><p>> ibuprofen~dexamethasone > ivermectin. The most efficient formulation was a liposomal formulation</p><p>composed of lipids that are present in the skin stratum corneum. Impermeability provided</p><p>by this formulation was notable mainly for the low-molecular-weight compounds, decreasing their</p><p>permeability coefficient by between 40 and 80%. The reinforcement of the barrier function of mucosa</p><p>provides a reduction or prevention of the permeation of different actives, which could be extrapolated</p><p>to toxic compounds such as viruses, contaminants, toxins, etc.</p>
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/208111
url https://hdl.handle.net/2445/208111
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/https://doi.org/10.3390/pharmaceutics15122698
Pharmaceutics, 2023, vol. 15, p. 2698
https://doi.org/https://doi.org/10.3390/pharmaceutics15122698
dc.rights.none.fl_str_mv cc-by (c) Coderch, L. et al., 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Coderch, L. et al., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420323385901056
score 15,300724

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