Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification

Heterotopic ossification (HO) is a condition triggered by an injury leading to the formation of mature lamellar bone in extraskeletal soft tissues. Despite being a frequent complication of orthopedic and trauma surgery, brain and spinal injury, the etiology of HO is poorly understood. The aim of thi...

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Autores: Bohner, Marc, Maazouz, Yassine, Ginebra, Maria Pau, Habibovic, Pamela, Schoenecker, Jonathan G., Seeherman, Howard, van den Beucken, Jeroen J.J.P., Witte, Frank
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/201906
Acesso em linha:https://hdl.handle.net/2445/201906
Access Level:Acceso aberto
Palavra-chave:Calcificació
Ossificació
Homeòstasi
Calcification
Ossification
Homeostasis
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spelling Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossificationBohner, MarcMaazouz, YassineGinebra, Maria PauHabibovic, PamelaSchoenecker, Jonathan G.Seeherman, Howardvan den Beucken, Jeroen J.J.P.Witte, FrankCalcificacióOssificacióHomeòstasiCalcificationOssificationHomeostasisHeterotopic ossification (HO) is a condition triggered by an injury leading to the formation of mature lamellar bone in extraskeletal soft tissues. Despite being a frequent complication of orthopedic and trauma surgery, brain and spinal injury, the etiology of HO is poorly understood. The aim of this study is to evaluate the hypothesis that a sustained local ionic homeostatic imbalance (SLIHI) created by mineral formation during tissue calcification modulates inflammation to trigger HO. This evaluation also considers the role SLIHI could play for the design of cell-free, drug-free osteoinductive bone graft substitutes. The evaluation contains five main sections. The first section defines relevant concepts in the context of HO and provides a summary of proposed causes of HO. The second section starts with a detailed analysis of the occurrence and involvement of calcification in HO. It is followed by an explanation of the causes of calcification and its consequences. This allows to speculate on the potential chemical modulators of inflammation and triggers of HO. The end of this second section is devoted to in vitro mineralization tests used to predict the ectopic potential of materials. The third section reviews the biological cascade of events occurring during pathological and material-induced HO, and attempts to propose a quantitative timeline of HO formation. The fourth section looks at potential ways to control HO formation, either acting on SLIHI or on inflammation. Chemical, physical, and drug-based approaches are considered. Finally, the evaluation finishes with a critical assessment of the definition of osteoinduction.Elsevier BV2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/201906Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléshttps://doi.org/10.1016/j.actbio.2022.03.057Acta Biomaterialia, 2022, vol. 145, p. 1-24https://doi.org/10.1016/j.actbio.2022.03.057cc by (c) Bohner, Marc et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2019062026-05-27T06:46:51Z
dc.title.none.fl_str_mv Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
title Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
spellingShingle Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
Bohner, Marc
Calcificació
Ossificació
Homeòstasi
Calcification
Ossification
Homeostasis
title_short Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
title_full Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
title_fullStr Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
title_full_unstemmed Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
title_sort Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
dc.creator.none.fl_str_mv Bohner, Marc
Maazouz, Yassine
Ginebra, Maria Pau
Habibovic, Pamela
Schoenecker, Jonathan G.
Seeherman, Howard
van den Beucken, Jeroen J.J.P.
Witte, Frank
author Bohner, Marc
author_facet Bohner, Marc
Maazouz, Yassine
Ginebra, Maria Pau
Habibovic, Pamela
Schoenecker, Jonathan G.
Seeherman, Howard
van den Beucken, Jeroen J.J.P.
Witte, Frank
author_role author
author2 Maazouz, Yassine
Ginebra, Maria Pau
Habibovic, Pamela
Schoenecker, Jonathan G.
Seeherman, Howard
van den Beucken, Jeroen J.J.P.
Witte, Frank
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Calcificació
Ossificació
Homeòstasi
Calcification
Ossification
Homeostasis
topic Calcificació
Ossificació
Homeòstasi
Calcification
Ossification
Homeostasis
description Heterotopic ossification (HO) is a condition triggered by an injury leading to the formation of mature lamellar bone in extraskeletal soft tissues. Despite being a frequent complication of orthopedic and trauma surgery, brain and spinal injury, the etiology of HO is poorly understood. The aim of this study is to evaluate the hypothesis that a sustained local ionic homeostatic imbalance (SLIHI) created by mineral formation during tissue calcification modulates inflammation to trigger HO. This evaluation also considers the role SLIHI could play for the design of cell-free, drug-free osteoinductive bone graft substitutes. The evaluation contains five main sections. The first section defines relevant concepts in the context of HO and provides a summary of proposed causes of HO. The second section starts with a detailed analysis of the occurrence and involvement of calcification in HO. It is followed by an explanation of the causes of calcification and its consequences. This allows to speculate on the potential chemical modulators of inflammation and triggers of HO. The end of this second section is devoted to in vitro mineralization tests used to predict the ectopic potential of materials. The third section reviews the biological cascade of events occurring during pathological and material-induced HO, and attempts to propose a quantitative timeline of HO formation. The fourth section looks at potential ways to control HO formation, either acting on SLIHI or on inflammation. Chemical, physical, and drug-based approaches are considered. Finally, the evaluation finishes with a critical assessment of the definition of osteoinduction.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/201906
url https://hdl.handle.net/2445/201906
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.actbio.2022.03.057
Acta Biomaterialia, 2022, vol. 145, p. 1-24
https://doi.org/10.1016/j.actbio.2022.03.057
dc.rights.none.fl_str_mv cc by (c) Bohner, Marc et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Bohner, Marc et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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