Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals

Background The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. Methods Subjects recently infected with HIV-1 were randomized to receive anti-retroviral treatment with or without maraviroc intensification for 48 weeks, and were monitored up...

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Autores: Kawana-Tachikawa, A., Llibre, Josep M., Bravo, Isabel, Escrig, R., Mothe, Beatriz, Puig, Jordi, Puertas, M.C., Martinez Picado, Francisco Javier, Blanco, Julià, Manzardo, C., Miró, J.M., Iwamoto, A., Pozniak, A.L., Gatell, J.M., Clotet, Bonaventura, Brander, Christian
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:UVic-UCC
Repositorio:RiUVic. Repositori institucional de la UVic-UCC
OAI Identifier:oai:dspace.uvic.cat:10854/2737
Acceso en línea:http://hdl.handle.net/10854/2737
https://doi.org/10.1371/journal.pone.0087334
Access Level:acceso abierto
Palabra clave:Sida -- Tractament
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spelling Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected IndividualsKawana-Tachikawa, A.Llibre, Josep M.Bravo, IsabelEscrig, R.Mothe, BeatrizPuig, JordiPuertas, M.C.Martinez Picado, Francisco JavierBlanco, JuliàManzardo, C.Miró, J.M.Iwamoto, A.Pozniak, A.L.Gatell, J.M.Clotet, BonaventuraBrander, ChristianSida -- TractamentBackground The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. Methods Subjects recently infected with HIV-1 were randomized to receive anti-retroviral treatment with or without maraviroc intensification for 48 weeks, and were monitored up to week 60. PBMC and in vitro-expanded T cells were tested for responses to the entire HIV proteome by ELISpot analyses. Intracellular cytokine staining assays were conducted to monitor the (poly)-functionality of HIV-1-specific T cells. Analyses were performed at baseline and week 24 after treatment start, and at week 60 (3 months after maraviroc discontinuation). Results Maraviroc intensification was associated with a slower decay of virus-specific T cell responses over time compared to the non-intensified regimen in both direct ex-vivo as well as in in-vitro expanded cells. The effector function profiles of virus-specific CD8+ T cells were indistinguishable between the two arms and did not change over time between the groups. Conclusions Maraviroc did not negatively impact any of the measured parameters, but was rather associated with a prolonged maintenance of HIV-1-specific T cell responses. Maraviroc, in addition to its original effect as viral entry inhibitor, may provide an additional benefit on the maintenance of virus-specific T cells which may be especially important for future viral eradication strategies.Public Library of ScienceUniversitat de Vic. Càtedra de la Sida i Malalties Relacionades2014201420142014info:eu-repo/semantics/articleinfo:eu-repo/publishedVersionapplication/pdf11 p.application/pdfhttp://hdl.handle.net/10854/2737https://doi.org/10.1371/journal.pone.0087334reponame:RiUVic. Repositori institucional de la UVic-UCCinstname:UVic-UCCIngléshttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0087334Aquest document està subjecte a aquesta llicència Creative Commonshttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:dspace.uvic.cat:10854/27372026-06-07T19:15:21Z
dc.title.none.fl_str_mv Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
title Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
spellingShingle Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
Kawana-Tachikawa, A.
Sida -- Tractament
title_short Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
title_full Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
title_fullStr Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
title_full_unstemmed Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
title_sort Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
dc.creator.none.fl_str_mv Kawana-Tachikawa, A.
Llibre, Josep M.
Bravo, Isabel
Escrig, R.
Mothe, Beatriz
Puig, Jordi
Puertas, M.C.
Martinez Picado, Francisco Javier
Blanco, Julià
Manzardo, C.
Miró, J.M.
Iwamoto, A.
Pozniak, A.L.
Gatell, J.M.
Clotet, Bonaventura
Brander, Christian
author Kawana-Tachikawa, A.
author_facet Kawana-Tachikawa, A.
Llibre, Josep M.
Bravo, Isabel
Escrig, R.
Mothe, Beatriz
Puig, Jordi
Puertas, M.C.
Martinez Picado, Francisco Javier
Blanco, Julià
Manzardo, C.
Miró, J.M.
Iwamoto, A.
Pozniak, A.L.
Gatell, J.M.
Clotet, Bonaventura
Brander, Christian
author_role author
author2 Llibre, Josep M.
Bravo, Isabel
Escrig, R.
Mothe, Beatriz
Puig, Jordi
Puertas, M.C.
Martinez Picado, Francisco Javier
Blanco, Julià
Manzardo, C.
Miró, J.M.
Iwamoto, A.
Pozniak, A.L.
Gatell, J.M.
Clotet, Bonaventura
Brander, Christian
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat de Vic. Càtedra de la Sida i Malalties Relacionades
dc.subject.none.fl_str_mv Sida -- Tractament
topic Sida -- Tractament
description Background The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. Methods Subjects recently infected with HIV-1 were randomized to receive anti-retroviral treatment with or without maraviroc intensification for 48 weeks, and were monitored up to week 60. PBMC and in vitro-expanded T cells were tested for responses to the entire HIV proteome by ELISpot analyses. Intracellular cytokine staining assays were conducted to monitor the (poly)-functionality of HIV-1-specific T cells. Analyses were performed at baseline and week 24 after treatment start, and at week 60 (3 months after maraviroc discontinuation). Results Maraviroc intensification was associated with a slower decay of virus-specific T cell responses over time compared to the non-intensified regimen in both direct ex-vivo as well as in in-vitro expanded cells. The effector function profiles of virus-specific CD8+ T cells were indistinguishable between the two arms and did not change over time between the groups. Conclusions Maraviroc did not negatively impact any of the measured parameters, but was rather associated with a prolonged maintenance of HIV-1-specific T cell responses. Maraviroc, in addition to its original effect as viral entry inhibitor, may provide an additional benefit on the maintenance of virus-specific T cells which may be especially important for future viral eradication strategies.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/publishedVersion
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10854/2737
https://doi.org/10.1371/journal.pone.0087334
url http://hdl.handle.net/10854/2737
https://doi.org/10.1371/journal.pone.0087334
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0087334
dc.rights.none.fl_str_mv Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
11 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:RiUVic. Repositori institucional de la UVic-UCC
instname:UVic-UCC
instname_str UVic-UCC
reponame_str RiUVic. Repositori institucional de la UVic-UCC
collection RiUVic. Repositori institucional de la UVic-UCC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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