Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data

Background/Objectives: This study aimed to assess the incidence of diabetic retinopathy (DR) in patients with type 2 diabetes (T2DM) treated in primary-care settings in Catalonia, Spain, and identify key risk factors associated with DR development. Methods: A retrospective cohort study was conducted...

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Autores: Hernández-Teixidó, C, de la Puente, JB, Jiménez, SM, Fernández-Camins, B, Mauricio, D, Aroca, PR, Vlacho, B, Franch-Nadal, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19039
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19039
http://ddd.uab.cat/record/310168
Access Level:acceso abierto
Palabra clave:diabetic retinopathy
incidence
type 2 diabetes mellitus
microvascular complications
primary care
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spelling Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World DataHernández-Teixidó, Cde la Puente, JBJiménez, SMFernández-Camins, BMauricio, DAroca, PRVlacho, BFranch-Nadal, Jdiabetic retinopathyincidencetype 2 diabetes mellitusmicrovascular complicationsprimary careBackground/Objectives: This study aimed to assess the incidence of diabetic retinopathy (DR) in patients with type 2 diabetes (T2DM) treated in primary-care settings in Catalonia, Spain, and identify key risk factors associated with DR development. Methods: A retrospective cohort study was conducted using the SIDIAP (System for Research and Development in Primary Care) database. Patients aged 30-90 with T2DM who underwent retinal screening between 2010 and 2015 were included. Multivariable Cox regression analysis was used to assess the impact of clinical variables, including HbA1c levels, diabetes duration, and comorbidities, on DR incidence. Results: This study included 146,506 patients, with a mean follow-up time of 6.96 years. During this period, 4.7% of the patients developed DR, resulting in an incidence rate of 6.99 per 1000 person-years. Higher HbA1c levels were strongly associated with an increased DR risk, with patients with HbA1c > 10% having more than four times the risk compared to those with HbA1c levels < 7% (hazard ratio: 4.23; 95% CI: 3.90-4.58). Other significant risk factors for DR included greater diabetes duration, male sex, ex-smoker status, macrovascular disease, and chronic kidney disease. In contrast, obesity appeared to be a protective factor against DR, with an HR of 0.93 (95% CI: 0.89-0.98). Conclusions: In our real-world setting, the incidence rate of DR was 6.99 per 1000 person-years. Poor glycemic control, especially HbA1c > 10%, and prolonged diabetes duration were key risk factors. Effective management of these factors is crucial in preventing DR progression. Regular retinal screenings in primary care play a vital role in early detection and reducing the DR burden for T2DM patients.MDPI2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19039http://ddd.uab.cat/record/310168Journal of Clinical MedicineISSN: 20770383reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p190392026-06-14T12:41:47Z
dc.title.none.fl_str_mv Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data
title Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data
spellingShingle Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data
Hernández-Teixidó, C
diabetic retinopathy
incidence
type 2 diabetes mellitus
microvascular complications
primary care
title_short Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data
title_full Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data
title_fullStr Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data
title_full_unstemmed Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data
title_sort Incidence of Diabetic Retinopathy in Individuals with Type 2 Diabetes: A Study Using Real-World Data
dc.creator.none.fl_str_mv Hernández-Teixidó, C
de la Puente, JB
Jiménez, SM
Fernández-Camins, B
Mauricio, D
Aroca, PR
Vlacho, B
Franch-Nadal, J
author Hernández-Teixidó, C
author_facet Hernández-Teixidó, C
de la Puente, JB
Jiménez, SM
Fernández-Camins, B
Mauricio, D
Aroca, PR
Vlacho, B
Franch-Nadal, J
author_role author
author2 de la Puente, JB
Jiménez, SM
Fernández-Camins, B
Mauricio, D
Aroca, PR
Vlacho, B
Franch-Nadal, J
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv diabetic retinopathy
incidence
type 2 diabetes mellitus
microvascular complications
primary care
topic diabetic retinopathy
incidence
type 2 diabetes mellitus
microvascular complications
primary care
description Background/Objectives: This study aimed to assess the incidence of diabetic retinopathy (DR) in patients with type 2 diabetes (T2DM) treated in primary-care settings in Catalonia, Spain, and identify key risk factors associated with DR development. Methods: A retrospective cohort study was conducted using the SIDIAP (System for Research and Development in Primary Care) database. Patients aged 30-90 with T2DM who underwent retinal screening between 2010 and 2015 were included. Multivariable Cox regression analysis was used to assess the impact of clinical variables, including HbA1c levels, diabetes duration, and comorbidities, on DR incidence. Results: This study included 146,506 patients, with a mean follow-up time of 6.96 years. During this period, 4.7% of the patients developed DR, resulting in an incidence rate of 6.99 per 1000 person-years. Higher HbA1c levels were strongly associated with an increased DR risk, with patients with HbA1c > 10% having more than four times the risk compared to those with HbA1c levels < 7% (hazard ratio: 4.23; 95% CI: 3.90-4.58). Other significant risk factors for DR included greater diabetes duration, male sex, ex-smoker status, macrovascular disease, and chronic kidney disease. In contrast, obesity appeared to be a protective factor against DR, with an HR of 0.93 (95% CI: 0.89-0.98). Conclusions: In our real-world setting, the incidence rate of DR was 6.99 per 1000 person-years. Poor glycemic control, especially HbA1c > 10%, and prolonged diabetes duration were key risk factors. Effective management of these factors is crucial in preventing DR progression. Regular retinal screenings in primary care play a vital role in early detection and reducing the DR burden for T2DM patients.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19039
http://ddd.uab.cat/record/310168
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19039
http://ddd.uab.cat/record/310168
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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