Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles

In this study, binary SiO2-CaO hollow mesoporous bioactive glass nanoparticles (HMBGNs) are prepared by combing selective etching and impregnation strategies. Spherical silica particles (SiO2 NPs) are used as hard cores to assemble cetyltrimethylammonium bromide (CTAB)/silica shells, which are later...

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Autores: Mutlu, Nurshen, Beltrán, Ana M., Nawaz, Qaisar, Michálek, Martin, Boccaccini, Aldo R., Zheng, Kai
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/125113
Acceso en línea:https://hdl.handle.net/11441/125113
https://doi.org/10.3390/nano11071846
Access Level:acceso abierto
Palabra clave:Bioactive glasses
Hollow mesoporous structure
Alkaline etching
Impregnation
Bone regeneratio
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spelling Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass NanoparticlesMutlu, NurshenBeltrán, Ana M.Nawaz, QaisarMichálek, MartinBoccaccini, Aldo R.Zheng, KaiBioactive glassesHollow mesoporous structureAlkaline etchingImpregnationBone regeneratioIn this study, binary SiO2-CaO hollow mesoporous bioactive glass nanoparticles (HMBGNs) are prepared by combing selective etching and impregnation strategies. Spherical silica particles (SiO2 NPs) are used as hard cores to assemble cetyltrimethylammonium bromide (CTAB)/silica shells, which are later removed by selective etching to generate a hollow structure. After the removal of CTAB by calcination, the mesoporous shell of particles is formed. Calcium (Ca) is incorporated into the particles using impregnation by soaking the etched SiO2 NPs in calcium nitrate aqueous solution. The amount of incorporated Ca is tailorable by controlling the ratio of SiO2 NPs:calcium nitrate in the soaking solution. The produced HMBGNs are bioactive, as indicated by the rapid formation of hydroxyapatite on their surfaces after immersion in simulated body fluid. In a direct culture with MC3T3-E1 cells, HMBGNs were shown to exhibit concentration-dependent cytotoxicity and can stimulate osteogenic differentiation of MC3T3-E1 cells at concentrations of 1, 0.5, and 0.25 mg/mL. Our results indicate that the combination of selective etching and impregnation is a feasible approach to produce hierarchical HMBGNs. The produced hollow particles have potential in drug delivery and bone tissue regeneration applications, and should be further investigated in detailed in vitro and in vivo studies.European Union’s Horizon 2020 research and innovation program 685872-MOZARTMDPIIngeniería y Ciencia de los Materiales y del TransporteTEP123: Metalurgia e Ingeniería de los Materiales2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/125113https://doi.org/10.3390/nano11071846reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésNanomaterials, 11 (7), 1846-.685872-MOZARThttps://www.mdpi.com/2079-4991/11/7/1846info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1251132026-06-17T12:51:07Z
dc.title.none.fl_str_mv Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles
title Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles
spellingShingle Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles
Mutlu, Nurshen
Bioactive glasses
Hollow mesoporous structure
Alkaline etching
Impregnation
Bone regeneratio
title_short Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles
title_full Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles
title_fullStr Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles
title_full_unstemmed Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles
title_sort Combination of Selective Etching and Impregnation toward Hollow Mesoporous Bioactive Glass Nanoparticles
dc.creator.none.fl_str_mv Mutlu, Nurshen
Beltrán, Ana M.
Nawaz, Qaisar
Michálek, Martin
Boccaccini, Aldo R.
Zheng, Kai
author Mutlu, Nurshen
author_facet Mutlu, Nurshen
Beltrán, Ana M.
Nawaz, Qaisar
Michálek, Martin
Boccaccini, Aldo R.
Zheng, Kai
author_role author
author2 Beltrán, Ana M.
Nawaz, Qaisar
Michálek, Martin
Boccaccini, Aldo R.
Zheng, Kai
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ingeniería y Ciencia de los Materiales y del Transporte
TEP123: Metalurgia e Ingeniería de los Materiales
dc.subject.none.fl_str_mv Bioactive glasses
Hollow mesoporous structure
Alkaline etching
Impregnation
Bone regeneratio
topic Bioactive glasses
Hollow mesoporous structure
Alkaline etching
Impregnation
Bone regeneratio
description In this study, binary SiO2-CaO hollow mesoporous bioactive glass nanoparticles (HMBGNs) are prepared by combing selective etching and impregnation strategies. Spherical silica particles (SiO2 NPs) are used as hard cores to assemble cetyltrimethylammonium bromide (CTAB)/silica shells, which are later removed by selective etching to generate a hollow structure. After the removal of CTAB by calcination, the mesoporous shell of particles is formed. Calcium (Ca) is incorporated into the particles using impregnation by soaking the etched SiO2 NPs in calcium nitrate aqueous solution. The amount of incorporated Ca is tailorable by controlling the ratio of SiO2 NPs:calcium nitrate in the soaking solution. The produced HMBGNs are bioactive, as indicated by the rapid formation of hydroxyapatite on their surfaces after immersion in simulated body fluid. In a direct culture with MC3T3-E1 cells, HMBGNs were shown to exhibit concentration-dependent cytotoxicity and can stimulate osteogenic differentiation of MC3T3-E1 cells at concentrations of 1, 0.5, and 0.25 mg/mL. Our results indicate that the combination of selective etching and impregnation is a feasible approach to produce hierarchical HMBGNs. The produced hollow particles have potential in drug delivery and bone tissue regeneration applications, and should be further investigated in detailed in vitro and in vivo studies.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/125113
https://doi.org/10.3390/nano11071846
url https://hdl.handle.net/11441/125113
https://doi.org/10.3390/nano11071846
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nanomaterials, 11 (7), 1846-.
685872-MOZART
https://www.mdpi.com/2079-4991/11/7/1846
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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