P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases

Human papillomavirus (HPV)-independent vulvar squamous cell carcinomas (VSCC) and its precursors frequently harbour TP53 mutations. Recently, six p53 immunohistochemical (IHC) patterns have been defined, which have shown strong correlation with TP53 mutation status. However, few studies have applied...

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Authors: Rakislova, Natalia, Alemany i Vilches, Laia, Clavero, Omar, Saco, Adela, Torné Bladé, Aureli, Pino Saladrigues, Marta del, Munmany, Meritxell, Rodrigo Calvo, María Teresa, Guerrero, José, Marimon, Lorena, Vega, Naiara, Quirós, Beatriz, Lloveras Rubio, Betlem, Ribera Cortada, Inmaculada, Alejo, Maria, Pawlita, Michael, Quint, Wim, Sanjosé Llongueras, Silvia de, Ordi i Majà, Jaume, VVAP Study Group
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173760
Online Access:https://hdl.handle.net/2445/173760
Access Level:Open access
Keyword:Papil·lomavirus
Càncer ginecològic
Papillomaviruses
Gynecologic cancer
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spelling P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 CasesRakislova, NataliaAlemany i Vilches, LaiaClavero, OmarSaco, AdelaTorné Bladé, AureliPino Saladrigues, Marta delMunmany, MeritxellRodrigo Calvo, María TeresaGuerrero, JoséMarimon, LorenaVega, NaiaraQuirós, BeatrizLloveras Rubio, BetlemRibera Cortada, InmaculadaAlejo, MariaPawlita, MichaelQuint, WimSanjosé Llongueras, Silvia deOrdi i Majà, JaumeVVAP Study GroupPapil·lomavirusCàncer ginecològicPapillomavirusesGynecologic cancerHuman papillomavirus (HPV)-independent vulvar squamous cell carcinomas (VSCC) and its precursors frequently harbour TP53 mutations. Recently, six p53 immunohistochemical (IHC) patterns have been defined, which have shown strong correlation with TP53 mutation status. However, few studies have applied this new six-pattern framework and none of them exhaustively compared p53 IHC positivity and patterns between invasive VSCC and adjacent skin lesion. We performed p53 IHC in a series of 779 HPV-independent VSCC with adjacent skin and evaluated the IHC slides following the newly described classification. Some 74.1% invasive VSCC showed abnormal p53 IHC staining. A skin lesion was identified in 450 cases (57.8%), including 254 intraepithelial precursors and 196 inflammatory/reactive lesions. Two hundred and ten of 450 (47%) VSCC with associated skin lesions showed an abnormal p53 IHC stain, with an identical staining pattern between the VSCC and the adjacent skin lesion in 80% of the cases. A total of 144/450 (32%) VSCC showed wild-type p53 IHC both in the invasive VSCC and adjacent skin lesion. Finally, 96/450 (21%) VSCC showed p53 IHC abnormal staining in the invasive VSCC but a wild-type p53 staining in the skin lesion. Most of the discordant cases (70/96; 73%) showed adjacent inflammatory lesions. In conclusion, the p53 IHC staining and pattern are usually identical in the VSCC and the intraepithelial precursor.MDPI2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/173760Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms21218091International Journal of Molecular Sciences, 2020, vol. 21, num21https://doi.org/10.3390/ijms21218091cc by (c) Rakislova et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1737602026-05-29T05:05:01Z
dc.title.none.fl_str_mv P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases
title P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases
spellingShingle P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases
Rakislova, Natalia
Papil·lomavirus
Càncer ginecològic
Papillomaviruses
Gynecologic cancer
title_short P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases
title_full P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases
title_fullStr P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases
title_full_unstemmed P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases
title_sort P53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases
dc.creator.none.fl_str_mv Rakislova, Natalia
Alemany i Vilches, Laia
Clavero, Omar
Saco, Adela
Torné Bladé, Aureli
Pino Saladrigues, Marta del
Munmany, Meritxell
Rodrigo Calvo, María Teresa
Guerrero, José
Marimon, Lorena
Vega, Naiara
Quirós, Beatriz
Lloveras Rubio, Betlem
Ribera Cortada, Inmaculada
Alejo, Maria
Pawlita, Michael
Quint, Wim
Sanjosé Llongueras, Silvia de
Ordi i Majà, Jaume
VVAP Study Group
author Rakislova, Natalia
author_facet Rakislova, Natalia
Alemany i Vilches, Laia
Clavero, Omar
Saco, Adela
Torné Bladé, Aureli
Pino Saladrigues, Marta del
Munmany, Meritxell
Rodrigo Calvo, María Teresa
Guerrero, José
Marimon, Lorena
Vega, Naiara
Quirós, Beatriz
Lloveras Rubio, Betlem
Ribera Cortada, Inmaculada
Alejo, Maria
Pawlita, Michael
Quint, Wim
Sanjosé Llongueras, Silvia de
Ordi i Majà, Jaume
VVAP Study Group
author_role author
author2 Alemany i Vilches, Laia
Clavero, Omar
Saco, Adela
Torné Bladé, Aureli
Pino Saladrigues, Marta del
Munmany, Meritxell
Rodrigo Calvo, María Teresa
Guerrero, José
Marimon, Lorena
Vega, Naiara
Quirós, Beatriz
Lloveras Rubio, Betlem
Ribera Cortada, Inmaculada
Alejo, Maria
Pawlita, Michael
Quint, Wim
Sanjosé Llongueras, Silvia de
Ordi i Majà, Jaume
VVAP Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Papil·lomavirus
Càncer ginecològic
Papillomaviruses
Gynecologic cancer
topic Papil·lomavirus
Càncer ginecològic
Papillomaviruses
Gynecologic cancer
description Human papillomavirus (HPV)-independent vulvar squamous cell carcinomas (VSCC) and its precursors frequently harbour TP53 mutations. Recently, six p53 immunohistochemical (IHC) patterns have been defined, which have shown strong correlation with TP53 mutation status. However, few studies have applied this new six-pattern framework and none of them exhaustively compared p53 IHC positivity and patterns between invasive VSCC and adjacent skin lesion. We performed p53 IHC in a series of 779 HPV-independent VSCC with adjacent skin and evaluated the IHC slides following the newly described classification. Some 74.1% invasive VSCC showed abnormal p53 IHC staining. A skin lesion was identified in 450 cases (57.8%), including 254 intraepithelial precursors and 196 inflammatory/reactive lesions. Two hundred and ten of 450 (47%) VSCC with associated skin lesions showed an abnormal p53 IHC stain, with an identical staining pattern between the VSCC and the adjacent skin lesion in 80% of the cases. A total of 144/450 (32%) VSCC showed wild-type p53 IHC both in the invasive VSCC and adjacent skin lesion. Finally, 96/450 (21%) VSCC showed p53 IHC abnormal staining in the invasive VSCC but a wild-type p53 staining in the skin lesion. Most of the discordant cases (70/96; 73%) showed adjacent inflammatory lesions. In conclusion, the p53 IHC staining and pattern are usually identical in the VSCC and the intraepithelial precursor.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173760
url https://hdl.handle.net/2445/173760
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms21218091
International Journal of Molecular Sciences, 2020, vol. 21, num21
https://doi.org/10.3390/ijms21218091
dc.rights.none.fl_str_mv cc by (c) Rakislova et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Rakislova et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420294364463104
score 15.811543

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