Overexpression of Scr1 protein induces strong changes in the transcriptome and metabolome of Streptomyces coelicolor that affect antibiotic production
Xenobiotic response element (XRE) regulator proteins play an important role in gene regulation in Streptomyces. In these bacteria, they are often encoded together with a small protein containing a DUF397 domain. Previous work on 15 such pairs present in S. coelicolor has shown they act as pleiotropi...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/418637 |
| Acceso en línea: | http://hdl.handle.net/10261/418637 https://api.elsevier.com/content/abstract/scopus_id/105018527981 |
| Access Level: | acceso abierto |
| Palabra clave: | Gene regulation Metabolome Streptomyces Transcriptome XRE/DUF397 |
| Sumario: | Xenobiotic response element (XRE) regulator proteins play an important role in gene regulation in Streptomyces. In these bacteria, they are often encoded together with a small protein containing a DUF397 domain. Previous work on 15 such pairs present in S. coelicolor has shown they act as pleiotropic regulators. They dependently affect antibiotic production and morphological differentiation on different culture media. Overexpression of the protein Scr1, which is encoded by gene SCO4441, induces a drastic increase in the production of the antibiotic actinorhodin in this bacterium. This study involves a transcriptomic and metabolomic study of this overexpression. |
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