Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study

Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional st...

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Autores: Sousa Pinto, Bernardo, Antó i Boqué, Josep Maria, MASK‐air think tank
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/60798
Acceso en línea:http://hdl.handle.net/10230/60798
http://dx.doi.org/10.1002/clt2.12358
Access Level:acceso abierto
Palabra clave:Asthma
Diagnosis
Dyspnea
mHealth
Wheezing
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spelling Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air studySousa Pinto, BernardoAntó i Boqué, Josep MariaMASK‐air think tankAsthmaDiagnosisDyspneamHealthWheezingRationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and main results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.BioMed Central202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60798http://dx.doi.org/10.1002/clt2.12358reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésClin Transl Allergy. 2024 Jun;14(6):e12358© 2024 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/607982026-06-12T07:21:37Z
dc.title.none.fl_str_mv Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
title Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
spellingShingle Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
Sousa Pinto, Bernardo
Asthma
Diagnosis
Dyspnea
mHealth
Wheezing
title_short Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
title_full Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
title_fullStr Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
title_full_unstemmed Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
title_sort Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study
dc.creator.none.fl_str_mv Sousa Pinto, Bernardo
Antó i Boqué, Josep Maria
MASK‐air think tank
author Sousa Pinto, Bernardo
author_facet Sousa Pinto, Bernardo
Antó i Boqué, Josep Maria
MASK‐air think tank
author_role author
author2 Antó i Boqué, Josep Maria
MASK‐air think tank
author2_role author
author
dc.subject.none.fl_str_mv Asthma
Diagnosis
Dyspnea
mHealth
Wheezing
topic Asthma
Diagnosis
Dyspnea
mHealth
Wheezing
description Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and main results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60798
http://dx.doi.org/10.1002/clt2.12358
url http://hdl.handle.net/10230/60798
http://dx.doi.org/10.1002/clt2.12358
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clin Transl Allergy. 2024 Jun;14(6):e12358
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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