Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles

We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together wit...

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Authors: Moreno Villaécija, Miguel Ángel|||0000-0003-2410-0682, Sedó Vegara, Josep|||0000-0002-4195-7541, Guisasola, Eduardo|||0000-0002-2549-1745, Baeza, Alejandro|||0000-0002-9042-8865, Vallet Regí, María|||0000-0002-6104-4889, Nador, Fabiana|||0000-0003-2502-0430, Ruiz-Molina, Daniel|||0000-0002-6844-8421
Format: article
Publication Date:2018
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:220667
Online Access:https://ddd.uab.cat/record/220667
https://dx.doi.org/urn:doi:10.1021/acsami.7b08584
Access Level:Open access
Keyword:Chemical nature
Coated systems
Mesoporous silica nanoparticles
Physicochemical property
Polydopamine
Reactive site
Release profiles
Synthetic methodology
Indoles
Nanoparticles
Polymers
Porosity
Silicon Dioxide
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oai_identifier_str oai:ddd.uab.cat:220667
network_acronym_str ES
network_name_str España
repository_id_str
spelling Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica NanoparticlesMoreno Villaécija, Miguel Ángel|||0000-0003-2410-0682Sedó Vegara, Josep|||0000-0002-4195-7541Guisasola, Eduardo|||0000-0002-2549-1745Baeza, Alejandro|||0000-0002-9042-8865Vallet Regí, María|||0000-0002-6104-4889Nador, Fabiana|||0000-0003-2502-0430Ruiz-Molina, Daniel|||0000-0002-6844-8421Chemical natureCoated systemsMesoporous silica nanoparticlesPhysicochemical propertyPolydopamineReactive siteRelease profilesSynthetic methodologyIndolesNanoparticlesPolymersPorositySilicon DioxideWe report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time. 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/220667https://dx.doi.org/urn:doi:10.1021/acsami.7b08584reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 MAT2015-70615-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 MAT2015-64831-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2013-0295European Commission https://doi.org/10.13039/501100000780 694160open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2206672026-06-06T12:50:31Z
dc.title.none.fl_str_mv Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
spellingShingle Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
Moreno Villaécija, Miguel Ángel|||0000-0003-2410-0682
Chemical nature
Coated systems
Mesoporous silica nanoparticles
Physicochemical property
Polydopamine
Reactive site
Release profiles
Synthetic methodology
Indoles
Nanoparticles
Polymers
Porosity
Silicon Dioxide
title_short Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title_full Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title_fullStr Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title_full_unstemmed Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
title_sort Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
dc.creator.none.fl_str_mv Moreno Villaécija, Miguel Ángel|||0000-0003-2410-0682
Sedó Vegara, Josep|||0000-0002-4195-7541
Guisasola, Eduardo|||0000-0002-2549-1745
Baeza, Alejandro|||0000-0002-9042-8865
Vallet Regí, María|||0000-0002-6104-4889
Nador, Fabiana|||0000-0003-2502-0430
Ruiz-Molina, Daniel|||0000-0002-6844-8421
author Moreno Villaécija, Miguel Ángel|||0000-0003-2410-0682
author_facet Moreno Villaécija, Miguel Ángel|||0000-0003-2410-0682
Sedó Vegara, Josep|||0000-0002-4195-7541
Guisasola, Eduardo|||0000-0002-2549-1745
Baeza, Alejandro|||0000-0002-9042-8865
Vallet Regí, María|||0000-0002-6104-4889
Nador, Fabiana|||0000-0003-2502-0430
Ruiz-Molina, Daniel|||0000-0002-6844-8421
author_role author
author2 Sedó Vegara, Josep|||0000-0002-4195-7541
Guisasola, Eduardo|||0000-0002-2549-1745
Baeza, Alejandro|||0000-0002-9042-8865
Vallet Regí, María|||0000-0002-6104-4889
Nador, Fabiana|||0000-0003-2502-0430
Ruiz-Molina, Daniel|||0000-0002-6844-8421
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Chemical nature
Coated systems
Mesoporous silica nanoparticles
Physicochemical property
Polydopamine
Reactive site
Release profiles
Synthetic methodology
Indoles
Nanoparticles
Polymers
Porosity
Silicon Dioxide
topic Chemical nature
Coated systems
Mesoporous silica nanoparticles
Physicochemical property
Polydopamine
Reactive site
Release profiles
Synthetic methodology
Indoles
Nanoparticles
Polymers
Porosity
Silicon Dioxide
description We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/220667
https://dx.doi.org/urn:doi:10.1021/acsami.7b08584
url https://ddd.uab.cat/record/220667
https://dx.doi.org/urn:doi:10.1021/acsami.7b08584
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MAT2015-70615-R
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MAT2015-64831-R
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2013-0295
European Commission https://doi.org/10.13039/501100000780 694160
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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