The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers

The aim of the study was to evaluate the influence of the red cabbage extracts on the bioaccessibility of their isothiocyanates, and their effect on the intestinal microbiota using a dynamic model of human digestion treated with the gut microbiome of obese adults. The elicitation of red cabbage plan...

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Autores: Garcia-Ibañez, Paula|||0000-0003-2117-3130, Rosés, Carles|||0000-0003-0060-9353, Agudelo, Agatha|||0000-0003-2324-6145, Milagro, Fermin I.|||0000-0002-3228-9916, Barceló Vernet, Anna|||0000-0002-5359-1698, Viadel, Blanca|||0000-0002-0279-3759, Nieto, Juan Antonio|||0000-0002-9266-0190, Moreno, Diego A.|||0000-0002-6547-8764, Carvajal, Micaela|||0000-0001-7321-4956
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255647
Acceso en línea:https://ddd.uab.cat/record/255647
https://dx.doi.org/urn:doi:10.3390/foods10051038
Access Level:acceso abierto
Palabra clave:Red cabbage
Isothiocyanates
Stability
Encapsulation
Gut microbiome
Obesity
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spelling The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese VolunteersGarcia-Ibañez, Paula|||0000-0003-2117-3130Rosés, Carles|||0000-0003-0060-9353Agudelo, Agatha|||0000-0003-2324-6145Milagro, Fermin I.|||0000-0002-3228-9916Barceló Vernet, Anna|||0000-0002-5359-1698Viadel, Blanca|||0000-0002-0279-3759Nieto, Juan Antonio|||0000-0002-9266-0190Moreno, Diego A.|||0000-0002-6547-8764Carvajal, Micaela|||0000-0001-7321-4956Red cabbageIsothiocyanatesStabilityEncapsulationGut microbiomeObesityThe aim of the study was to evaluate the influence of the red cabbage extracts on the bioaccessibility of their isothiocyanates, and their effect on the intestinal microbiota using a dynamic model of human digestion treated with the gut microbiome of obese adults. The elicitation of red cabbage plants with methyl jasmonate (MeJA) duplicated the content of glucosinolates (GSLs) in the plant organs used for elaborating the encapsulated formula. The use of plasma membrane vesicles, according to a proper methodology and technology, showed a high retention of sulforaphane (SFN) and indol-3-carbinol (I3C) over the course of the 14-day digestion study. The microbiome was scarcely affected by the treatments in terms of microbiota composition or the Bacteroidetes/Firmicutes ratio, but a 3 to 4-fold increase was observed in the production of butyric acid with the encapsulated extract treatment. Based on our pilot red cabbage extract study, the consumption of this extract, mainly encapsulated, may play a potential role in the management of obesity in adults. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255647https://dx.doi.org/urn:doi:10.3390/foods10051038reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-80247-C2-1-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2556472026-06-06T12:50:31Z
dc.title.none.fl_str_mv The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers
title The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers
spellingShingle The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers
Garcia-Ibañez, Paula|||0000-0003-2117-3130
Red cabbage
Isothiocyanates
Stability
Encapsulation
Gut microbiome
Obesity
title_short The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers
title_full The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers
title_fullStr The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers
title_full_unstemmed The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers
title_sort The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers
dc.creator.none.fl_str_mv Garcia-Ibañez, Paula|||0000-0003-2117-3130
Rosés, Carles|||0000-0003-0060-9353
Agudelo, Agatha|||0000-0003-2324-6145
Milagro, Fermin I.|||0000-0002-3228-9916
Barceló Vernet, Anna|||0000-0002-5359-1698
Viadel, Blanca|||0000-0002-0279-3759
Nieto, Juan Antonio|||0000-0002-9266-0190
Moreno, Diego A.|||0000-0002-6547-8764
Carvajal, Micaela|||0000-0001-7321-4956
author Garcia-Ibañez, Paula|||0000-0003-2117-3130
author_facet Garcia-Ibañez, Paula|||0000-0003-2117-3130
Rosés, Carles|||0000-0003-0060-9353
Agudelo, Agatha|||0000-0003-2324-6145
Milagro, Fermin I.|||0000-0002-3228-9916
Barceló Vernet, Anna|||0000-0002-5359-1698
Viadel, Blanca|||0000-0002-0279-3759
Nieto, Juan Antonio|||0000-0002-9266-0190
Moreno, Diego A.|||0000-0002-6547-8764
Carvajal, Micaela|||0000-0001-7321-4956
author_role author
author2 Rosés, Carles|||0000-0003-0060-9353
Agudelo, Agatha|||0000-0003-2324-6145
Milagro, Fermin I.|||0000-0002-3228-9916
Barceló Vernet, Anna|||0000-0002-5359-1698
Viadel, Blanca|||0000-0002-0279-3759
Nieto, Juan Antonio|||0000-0002-9266-0190
Moreno, Diego A.|||0000-0002-6547-8764
Carvajal, Micaela|||0000-0001-7321-4956
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Red cabbage
Isothiocyanates
Stability
Encapsulation
Gut microbiome
Obesity
topic Red cabbage
Isothiocyanates
Stability
Encapsulation
Gut microbiome
Obesity
description The aim of the study was to evaluate the influence of the red cabbage extracts on the bioaccessibility of their isothiocyanates, and their effect on the intestinal microbiota using a dynamic model of human digestion treated with the gut microbiome of obese adults. The elicitation of red cabbage plants with methyl jasmonate (MeJA) duplicated the content of glucosinolates (GSLs) in the plant organs used for elaborating the encapsulated formula. The use of plasma membrane vesicles, according to a proper methodology and technology, showed a high retention of sulforaphane (SFN) and indol-3-carbinol (I3C) over the course of the 14-day digestion study. The microbiome was scarcely affected by the treatments in terms of microbiota composition or the Bacteroidetes/Firmicutes ratio, but a 3 to 4-fold increase was observed in the production of butyric acid with the encapsulated extract treatment. Based on our pilot red cabbage extract study, the consumption of this extract, mainly encapsulated, may play a potential role in the management of obesity in adults.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/255647
https://dx.doi.org/urn:doi:10.3390/foods10051038
url https://ddd.uab.cat/record/255647
https://dx.doi.org/urn:doi:10.3390/foods10051038
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-80247-C2-1-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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