Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers

The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)-nanocarrier system that binds efficiently to siglec-10, a member of the CD33 family of...

ver descrição completa

Detalhes bibliográficos
Autores: Almeida Marrero, Verónica, Bethlehem, Fleur, Longo, Sara, Bertolino, M. Candelaria, Torres Cebada, Tomás, Huskens, Jurriaan, Escosura Navazo, Andrés de la
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universidad Autónoma de Madrid
Repositório:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglês
OAI Identifier:oai:repositorio.uam.es:10486/703386
Acesso em linha:http://hdl.handle.net/10486/703386
https://dx.doi.org/10.1002/anie.202206900
Access Level:Acceso aberto
Palavra-chave:Liposome Nanocarriers
Multivalency
Photosensitizer
Siglecs
Química
id ES_d19f20eaefddb2b0713544bbc93def53
oai_identifier_str oai:repositorio.uam.es:10486/703386
network_acronym_str ES
network_name_str España
repository_id_str
spelling Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome NanocarriersAlmeida Marrero, VerónicaBethlehem, FleurLongo, SaraBertolino, M. CandelariaTorres Cebada, TomásHuskens, JurriaanEscosura Navazo, Andrés de laLiposome NanocarriersMultivalencyPhotosensitizerSiglecsQuímicaThe modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)-nanocarrier system that binds efficiently to siglec-10, a member of the CD33 family of siglecs (sialic acid (SA)-binding immunoglobulin-like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec-10-displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS-loaded SUVs shows the potential for targeting siglec-expressing cells with photosensitizing nanocarriersThis work was supported by MINECO-Feder funds [PID2020-116490GB-I00, Porphyrinoids (T.T.) and PID2020-119306GB-100 (AdlE)]. IMDEA Nanociencia also acknowledges support from the “Severo Ochoa” Programme for Centres of Excellence in R&D (MINECO, Grant SEV2016-0686). S.L. and M.C.B. acknowledge financial support by The Netherlands Organization for Scientific Research (NWO, TOP grant 715.015.001 to J.H.)WileyDepartamento de Química OrgánicaFacultad de Ciencias20222022-06-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/703386https://dx.doi.org/10.1002/anie.202206900reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7033862026-06-23T12:46:27Z
dc.title.none.fl_str_mv Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
title Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
spellingShingle Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
Almeida Marrero, Verónica
Liposome Nanocarriers
Multivalency
Photosensitizer
Siglecs
Química
title_short Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
title_full Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
title_fullStr Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
title_full_unstemmed Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
title_sort Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
dc.creator.none.fl_str_mv Almeida Marrero, Verónica
Bethlehem, Fleur
Longo, Sara
Bertolino, M. Candelaria
Torres Cebada, Tomás
Huskens, Jurriaan
Escosura Navazo, Andrés de la
author Almeida Marrero, Verónica
author_facet Almeida Marrero, Verónica
Bethlehem, Fleur
Longo, Sara
Bertolino, M. Candelaria
Torres Cebada, Tomás
Huskens, Jurriaan
Escosura Navazo, Andrés de la
author_role author
author2 Bethlehem, Fleur
Longo, Sara
Bertolino, M. Candelaria
Torres Cebada, Tomás
Huskens, Jurriaan
Escosura Navazo, Andrés de la
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Química Orgánica
Facultad de Ciencias
dc.subject.none.fl_str_mv Liposome Nanocarriers
Multivalency
Photosensitizer
Siglecs
Química
topic Liposome Nanocarriers
Multivalency
Photosensitizer
Siglecs
Química
description The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)-nanocarrier system that binds efficiently to siglec-10, a member of the CD33 family of siglecs (sialic acid (SA)-binding immunoglobulin-like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec-10-displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS-loaded SUVs shows the potential for targeting siglec-expressing cells with photosensitizing nanocarriers
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-06-02
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/703386
https://dx.doi.org/10.1002/anie.202206900
url http://hdl.handle.net/10486/703386
https://dx.doi.org/10.1002/anie.202206900
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420279299571712
score 15,300724

Registros relacionados