Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock

The heat-shock response plays a key role in the immune defence against viruses across various organisms. Studies on model organisms have shown that inducing this response prior to viral exposure enhances host resistance to infections, while deficient responses make individuals more susceptible. More...

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Detalles Bibliográficos
Autores: Castiglioni, Victoria G., Elena, Santiago F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/383665
Acceso en línea:http://hdl.handle.net/10261/383665
Access Level:acceso abierto
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spelling Orsay virus infection increases Caenorhabditis elegans resistance to heat-shockCastiglioni, Victoria G.Elena, Santiago F.The heat-shock response plays a key role in the immune defence against viruses across various organisms. Studies on model organisms have shown that inducing this response prior to viral exposure enhances host resistance to infections, while deficient responses make individuals more susceptible. Moreover, viruses rely on components of the heat-shock response for their own stability and viral infections improve thermal tolerance in plants, giving infected individuals an advantage in extreme conditions, which aids the virus in replication and transmission. Here, we examine the interaction between the nematode Caenorhabditis elegans and its natural pathogen the Orsay virus (OrV) under heat stress. We found that OrV infection leads to differential expression of heat-stress-related genes, and infected populations show increased resistance to heat-shock. This resistance correlates with increased expression of argonautes alg-1 and alg-2, which are crucial for survival after heat-shock and for OrV replication. Overall, our study suggests an environmental-dependent mutualistic relationship between the nematode and OrV, potentially expanding the animal’s ecological niche and providing the virus with extra opportunities for replication and adaptation to extreme conditions.This work is supported by grants PID2022-136912NB-I00 funded by MCIN/AEI/10.13039/501100011033 and by ‘ERDF a way of making Europe’, and CIPROM/2022/59 funded by Generalitat Valenciana to S.F.E. V.G.C. was supported by grant FJC2021-047264-I funded by MCIN/AEI/10.13039/501100011033 and by NextGenerationEU/PRTR.Peer reviewedRoyal Society (Great Britain)Agencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionGeneralitat ValencianaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/383665reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136912NB-I00info:eu-repo/grantAgreement/AEI//FJC2021-047264-ICastiglioni, Victoria; Elena, Santiago; 2024; Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock [Dataset]; Dryad; https://doi.org/10.5061/dryad.866t1g1zshttps://doi.org/10.1098/rsbl.2024.0278Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3836652026-05-22T06:33:51Z
dc.title.none.fl_str_mv Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock
title Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock
spellingShingle Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock
Castiglioni, Victoria G.
title_short Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock
title_full Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock
title_fullStr Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock
title_full_unstemmed Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock
title_sort Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock
dc.creator.none.fl_str_mv Castiglioni, Victoria G.
Elena, Santiago F.
author Castiglioni, Victoria G.
author_facet Castiglioni, Victoria G.
Elena, Santiago F.
author_role author
author2 Elena, Santiago F.
author2_role author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Generalitat Valenciana
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description The heat-shock response plays a key role in the immune defence against viruses across various organisms. Studies on model organisms have shown that inducing this response prior to viral exposure enhances host resistance to infections, while deficient responses make individuals more susceptible. Moreover, viruses rely on components of the heat-shock response for their own stability and viral infections improve thermal tolerance in plants, giving infected individuals an advantage in extreme conditions, which aids the virus in replication and transmission. Here, we examine the interaction between the nematode Caenorhabditis elegans and its natural pathogen the Orsay virus (OrV) under heat stress. We found that OrV infection leads to differential expression of heat-stress-related genes, and infected populations show increased resistance to heat-shock. This resistance correlates with increased expression of argonautes alg-1 and alg-2, which are crucial for survival after heat-shock and for OrV replication. Overall, our study suggests an environmental-dependent mutualistic relationship between the nematode and OrV, potentially expanding the animal’s ecological niche and providing the virus with extra opportunities for replication and adaptation to extreme conditions.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/383665
url http://hdl.handle.net/10261/383665
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136912NB-I00
info:eu-repo/grantAgreement/AEI//FJC2021-047264-I
Castiglioni, Victoria; Elena, Santiago; 2024; Orsay virus infection increases Caenorhabditis elegans resistance to heat-shock [Dataset]; Dryad; https://doi.org/10.5061/dryad.866t1g1zs
https://doi.org/10.1098/rsbl.2024.0278
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society (Great Britain)
publisher.none.fl_str_mv Royal Society (Great Britain)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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