Assessing therapeutic decisions in generalized myasthenia gravis
Background The therapeutic landscape in generalized myasthenia gravis (gMG) has been continuously evolving in recent years, with over five products approved, each with different efficacy, safety, and administration profiles. With the availability of new targeted treatments, physicians are faced with...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:322603 |
| Acceso en línea: | https://ddd.uab.cat/record/322603 https://dx.doi.org/urn:doi:10.1371/journal.pone.0322168 |
| Access Level: | acceso abierto |
| Palabra clave: | Adult Clinical Decision-Making Cross-Sectional Studies Decision Making Female Humans Male Myasthenia Gravis Neurologists Surveys and Questionnaires |
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Assessing therapeutic decisions in generalized myasthenia gravisStudy protocolGutiérrez-Gutiérrez, GerardoGómez-Ballesteros, R.|||0000-0001-9582-9230Sotoca Fernández, Javier|||0000-0003-3400-1434Ares, A.Villaverde, R.Reyes-Garrido, VirginiaArmangué, T.Salas, Eduardo|||0000-0002-6837-2471Díaz-Abós, P.Rebollo, P.Sarmiento, M.Escobar, I.Maurino, Jorge|||0000-0001-9858-3555Querol, Luis|||0000-0002-4289-8264AdultClinical Decision-MakingCross-Sectional StudiesDecision MakingFemaleHumansMaleMyasthenia GravisNeurologistsSurveys and QuestionnairesBackground The therapeutic landscape in generalized myasthenia gravis (gMG) has been continuously evolving in recent years, with over five products approved, each with different efficacy, safety, and administration profiles. With the availability of new targeted treatments, physicians are faced with the challenge of therapeutic decision-making tailored to traditional therapeutic goals, individual preferences, and personal experience, seeking optimal disease control with a positive safety profile. In this context of uncertainty and multiple novel choices, this study aims to provide insights into the preferred treatment choices of neurologists managing gMG and to identify demographic, professional or behavioral factors influencing the decision-making process. Methods This is a non-interventional, cross-sectional, web-based study involving 150 neurologists treating gMG patients in collaboration with the Spanish Society of Neurology. The primary endpoint will be to assess preferences for different gMG treatment attributes using a conjoint analysis to create hypothetical treatment scenarios. Therapeutic inertia, described as the lack of treatment initiation or intensification when therapeutic goals are not met, will be evaluated as a secondary endpoint through 7 case scenarios simulating real gMG clinical practice situations. Neurologists will also answer a survey composed of demographic, professional, and behavioral characteristics (user resistance behavior, care-related regret, burnout, risk attitude, empathy, work fulfilment, and personality traits) to recognize possible factors influencing decisions. Conclusions The study findings will contribute to better understanding of decision-making in gMG under a changing therapeutic landscape with multiple new targeted options, and will identify which factors have a role in affecting those decisions.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/322603https://dx.doi.org/urn:doi:10.1371/journal.pone.0322168reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3226032026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Assessing therapeutic decisions in generalized myasthenia gravis Study protocol |
| title |
Assessing therapeutic decisions in generalized myasthenia gravis |
| spellingShingle |
Assessing therapeutic decisions in generalized myasthenia gravis Gutiérrez-Gutiérrez, Gerardo Adult Clinical Decision-Making Cross-Sectional Studies Decision Making Female Humans Male Myasthenia Gravis Neurologists Surveys and Questionnaires |
| title_short |
Assessing therapeutic decisions in generalized myasthenia gravis |
| title_full |
Assessing therapeutic decisions in generalized myasthenia gravis |
| title_fullStr |
Assessing therapeutic decisions in generalized myasthenia gravis |
| title_full_unstemmed |
Assessing therapeutic decisions in generalized myasthenia gravis |
| title_sort |
Assessing therapeutic decisions in generalized myasthenia gravis |
| dc.creator.none.fl_str_mv |
Gutiérrez-Gutiérrez, Gerardo Gómez-Ballesteros, R.|||0000-0001-9582-9230 Sotoca Fernández, Javier|||0000-0003-3400-1434 Ares, A. Villaverde, R. Reyes-Garrido, Virginia Armangué, T. Salas, Eduardo|||0000-0002-6837-2471 Díaz-Abós, P. Rebollo, P. Sarmiento, M. Escobar, I. Maurino, Jorge|||0000-0001-9858-3555 Querol, Luis|||0000-0002-4289-8264 |
| author |
Gutiérrez-Gutiérrez, Gerardo |
| author_facet |
Gutiérrez-Gutiérrez, Gerardo Gómez-Ballesteros, R.|||0000-0001-9582-9230 Sotoca Fernández, Javier|||0000-0003-3400-1434 Ares, A. Villaverde, R. Reyes-Garrido, Virginia Armangué, T. Salas, Eduardo|||0000-0002-6837-2471 Díaz-Abós, P. Rebollo, P. Sarmiento, M. Escobar, I. Maurino, Jorge|||0000-0001-9858-3555 Querol, Luis|||0000-0002-4289-8264 |
| author_role |
author |
| author2 |
Gómez-Ballesteros, R.|||0000-0001-9582-9230 Sotoca Fernández, Javier|||0000-0003-3400-1434 Ares, A. Villaverde, R. Reyes-Garrido, Virginia Armangué, T. Salas, Eduardo|||0000-0002-6837-2471 Díaz-Abós, P. Rebollo, P. Sarmiento, M. Escobar, I. Maurino, Jorge|||0000-0001-9858-3555 Querol, Luis|||0000-0002-4289-8264 |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Medicina |
| dc.subject.none.fl_str_mv |
Adult Clinical Decision-Making Cross-Sectional Studies Decision Making Female Humans Male Myasthenia Gravis Neurologists Surveys and Questionnaires |
| topic |
Adult Clinical Decision-Making Cross-Sectional Studies Decision Making Female Humans Male Myasthenia Gravis Neurologists Surveys and Questionnaires |
| description |
Background The therapeutic landscape in generalized myasthenia gravis (gMG) has been continuously evolving in recent years, with over five products approved, each with different efficacy, safety, and administration profiles. With the availability of new targeted treatments, physicians are faced with the challenge of therapeutic decision-making tailored to traditional therapeutic goals, individual preferences, and personal experience, seeking optimal disease control with a positive safety profile. In this context of uncertainty and multiple novel choices, this study aims to provide insights into the preferred treatment choices of neurologists managing gMG and to identify demographic, professional or behavioral factors influencing the decision-making process. Methods This is a non-interventional, cross-sectional, web-based study involving 150 neurologists treating gMG patients in collaboration with the Spanish Society of Neurology. The primary endpoint will be to assess preferences for different gMG treatment attributes using a conjoint analysis to create hypothetical treatment scenarios. Therapeutic inertia, described as the lack of treatment initiation or intensification when therapeutic goals are not met, will be evaluated as a secondary endpoint through 7 case scenarios simulating real gMG clinical practice situations. Neurologists will also answer a survey composed of demographic, professional, and behavioral characteristics (user resistance behavior, care-related regret, burnout, risk attitude, empathy, work fulfilment, and personality traits) to recognize possible factors influencing decisions. Conclusions The study findings will contribute to better understanding of decision-making in gMG under a changing therapeutic landscape with multiple new targeted options, and will identify which factors have a role in affecting those decisions. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
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Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/322603 https://dx.doi.org/urn:doi:10.1371/journal.pone.0322168 |
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https://ddd.uab.cat/record/322603 https://dx.doi.org/urn:doi:10.1371/journal.pone.0322168 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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