Characterization of NT-proBNP in a large cohort of COVID-19 patients
Aims: Extensive research regarding the association of troponin and prognosis in coronavirus disease 2019 (COVID-19) has been performed. However, data regarding natriuretic peptides are scarce. N-terminal pro B-type natriuretic peptide (NT-proBNP) reflects haemodynamic stress and has proven useful fo...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/717209 |
| Acceso en línea: | http://hdl.handle.net/10486/717209 https://dx.doi.org/10.1002/ejhf.2095 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 heart failure mortality natriuretic peptides NT-proBNP prognosis Medicina |
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Characterization of NT-proBNP in a large cohort of COVID-19 patientsCaro Codón, JuanRey Blas, Juan RamónBuño, AntonioIniesta, Ángel M.Rosillo, Sandra O.Castrejón Castrejón, SergioRodriguez Sotelo, LauraMartinez, Luis A.Marco, IreneMerino, CarlosMartín Polo, LorenaGarcía Veas, Jose M.Martinez Cossiani, MarcelGonzález Valle, LuisHerrero, AliciaLópez de Sa Areses, Esteban AdolfoMerino, José L.COVID-19heart failuremortalitynatriuretic peptidesNT-proBNPprognosisMedicinaAims: Extensive research regarding the association of troponin and prognosis in coronavirus disease 2019 (COVID-19) has been performed. However, data regarding natriuretic peptides are scarce. N-terminal pro B-type natriuretic peptide (NT-proBNP) reflects haemodynamic stress and has proven useful for risk stratification in heart failure (HF) and other conditions such as pulmonary embolism and pneumonia. We aimed to adequately characterize NT-proBNP concentrations using a large cohort of patients with COVID-19, and to investigate its association with prognosis. Methods and results: Consecutive patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and available NT-proBNP determinations, from March 1st to April 20th, 2020 who completed at least 1-month follow-up or died, were studied. Of 3080 screened patients, a total of 396 (mean age 71.8 ± 14.6 years, 61.1% male) fulfilled all the selection criteria and were finally included, with a median follow-up of 53 (18–62) days. Of those, 192 (48.5%) presented NT-proBNP levels above the recommended cut-off for the identification of HF. However, only 47 fulfilled the clinical criteria for the diagnosis of HF. Patients with higher NT-proBNP during admission experienced more frequent bleeding, arrhythmias and HF decompensations. NT-proBNP was associated with mortality both in the whole study population and after excluding patients with HF. A multivariable Cox model confirmed that NT-proBNP was independently associated with mortality after adjusting for all relevant confounders (hazard ratio 1.28, 95% confidence interval 1.13–1.44, per logarithmic unit). Conclusion: NT-proBNP is frequently elevated in COVID-19. It is strongly and independently associated with mortality after adjusting for relevant confounders, including chronic HF and acute HF. Therefore, its use may improve early prognostic stratification in this conditionWileyDepartamento de MedicinaFacultad de Medicina20212021-03-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/717209https://dx.doi.org/10.1002/ejhf.2095reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7172092026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Characterization of NT-proBNP in a large cohort of COVID-19 patients |
| title |
Characterization of NT-proBNP in a large cohort of COVID-19 patients |
| spellingShingle |
Characterization of NT-proBNP in a large cohort of COVID-19 patients Caro Codón, Juan COVID-19 heart failure mortality natriuretic peptides NT-proBNP prognosis Medicina |
| title_short |
Characterization of NT-proBNP in a large cohort of COVID-19 patients |
| title_full |
Characterization of NT-proBNP in a large cohort of COVID-19 patients |
| title_fullStr |
Characterization of NT-proBNP in a large cohort of COVID-19 patients |
| title_full_unstemmed |
Characterization of NT-proBNP in a large cohort of COVID-19 patients |
| title_sort |
Characterization of NT-proBNP in a large cohort of COVID-19 patients |
| dc.creator.none.fl_str_mv |
Caro Codón, Juan Rey Blas, Juan Ramón Buño, Antonio Iniesta, Ángel M. Rosillo, Sandra O. Castrejón Castrejón, Sergio Rodriguez Sotelo, Laura Martinez, Luis A. Marco, Irene Merino, Carlos Martín Polo, Lorena García Veas, Jose M. Martinez Cossiani, Marcel González Valle, Luis Herrero, Alicia López de Sa Areses, Esteban Adolfo Merino, José L. |
| author |
Caro Codón, Juan |
| author_facet |
Caro Codón, Juan Rey Blas, Juan Ramón Buño, Antonio Iniesta, Ángel M. Rosillo, Sandra O. Castrejón Castrejón, Sergio Rodriguez Sotelo, Laura Martinez, Luis A. Marco, Irene Merino, Carlos Martín Polo, Lorena García Veas, Jose M. Martinez Cossiani, Marcel González Valle, Luis Herrero, Alicia López de Sa Areses, Esteban Adolfo Merino, José L. |
| author_role |
author |
| author2 |
Rey Blas, Juan Ramón Buño, Antonio Iniesta, Ángel M. Rosillo, Sandra O. Castrejón Castrejón, Sergio Rodriguez Sotelo, Laura Martinez, Luis A. Marco, Irene Merino, Carlos Martín Polo, Lorena García Veas, Jose M. Martinez Cossiani, Marcel González Valle, Luis Herrero, Alicia López de Sa Areses, Esteban Adolfo Merino, José L. |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Facultad de Medicina |
| dc.subject.none.fl_str_mv |
COVID-19 heart failure mortality natriuretic peptides NT-proBNP prognosis Medicina |
| topic |
COVID-19 heart failure mortality natriuretic peptides NT-proBNP prognosis Medicina |
| description |
Aims: Extensive research regarding the association of troponin and prognosis in coronavirus disease 2019 (COVID-19) has been performed. However, data regarding natriuretic peptides are scarce. N-terminal pro B-type natriuretic peptide (NT-proBNP) reflects haemodynamic stress and has proven useful for risk stratification in heart failure (HF) and other conditions such as pulmonary embolism and pneumonia. We aimed to adequately characterize NT-proBNP concentrations using a large cohort of patients with COVID-19, and to investigate its association with prognosis. Methods and results: Consecutive patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and available NT-proBNP determinations, from March 1st to April 20th, 2020 who completed at least 1-month follow-up or died, were studied. Of 3080 screened patients, a total of 396 (mean age 71.8 ± 14.6 years, 61.1% male) fulfilled all the selection criteria and were finally included, with a median follow-up of 53 (18–62) days. Of those, 192 (48.5%) presented NT-proBNP levels above the recommended cut-off for the identification of HF. However, only 47 fulfilled the clinical criteria for the diagnosis of HF. Patients with higher NT-proBNP during admission experienced more frequent bleeding, arrhythmias and HF decompensations. NT-proBNP was associated with mortality both in the whole study population and after excluding patients with HF. A multivariable Cox model confirmed that NT-proBNP was independently associated with mortality after adjusting for all relevant confounders (hazard ratio 1.28, 95% confidence interval 1.13–1.44, per logarithmic unit). Conclusion: NT-proBNP is frequently elevated in COVID-19. It is strongly and independently associated with mortality after adjusting for relevant confounders, including chronic HF and acute HF. Therefore, its use may improve early prognostic stratification in this condition |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-03-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
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info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/717209 https://dx.doi.org/10.1002/ejhf.2095 |
| url |
http://hdl.handle.net/10486/717209 https://dx.doi.org/10.1002/ejhf.2095 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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