Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis

Incluye 7 ficheros de datos

Detalles Bibliográficos
Autores: Faus, Isabel, Zabalza Aznárez, Ana, Santiago, Julia, Nebauer, Sergio G., Royuela Hernando, Mercedes, Serrano, Ramón, Gadea, José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/18633
Acceso en línea:https://hdl.handle.net/2454/18633
Access Level:acceso abierto
Palabra clave:Glyphosate
GCN2
Transcriptomic
Shikimate
Translation
Herbicides
Horseweed conyza-canadensis
Sugar-beet leaves
Herbicide resistance
Vacuolar sequestration
Phosphate transporter
Gene expression
Thaliana
Stress
EIF2-alpha
Wheat
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spelling Protein kinase GCN2 mediates responses to glyphosate in ArabidopsisFaus, IsabelZabalza Aznárez, AnaSantiago, JuliaNebauer, Sergio G.Royuela Hernando, MercedesSerrano, RamónGadea, JoséGlyphosateGCN2TranscriptomicShikimateTranslationHerbicidesHorseweed conyza-canadensisSugar-beet leavesHerbicide resistanceVacuolar sequestrationPhosphate transporterGene expressionThalianaStressEIF2-alphaWheatIncluye 7 ficheros de datosBackground: The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified. Results: In this study, we identify the protein kinase GCN2 as a cellular component that fosters the action of glyphosate in the model plant Arabidopsis thaliana. Comparative studies using wild-type and gcn2 knock-out mutant seedlings show that the molecular programme that the plant deploys after the treatment with the herbicide, is compromised in gcn2. Moreover, gcn2 adult plants show a lower inhibition of photosynthesis, and both seedlings and adult gcn2 plants accumulate less shikimic acid than wild-type after treatment with glyphosate. Conclusions: These results points to an unknown GCN2-dependent factor involved in the cascade of events triggered by glyphosate in plants. Data suggest either that the herbicide does not equally reach the target-enzyme in a gcn2 background, or that a decreased flux in the shikimate pathway in a gcn2 plants minimize the impact of enzyme inhibition.This work was mainly supported by the Universidad Politecnica de Valencia (PAID2011-16) and the Ministerio Español de Ciencia y Tecnología (BFU2011-22526). The work was partially supported through a grant from the Ministerio Español de Ciencia y Tecnología (AGL-2010-18621).BioMed CentralCiencias del Medio NaturalNatura Ingurunearen Zientziak2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/ziphttps://hdl.handle.net/2454/18633reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/MICINN//BFU2011-22526info:eu-repo/grantAgreement/MICINN//AGL2010-18621© 2015 Faus et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/186332026-06-17T12:41:47Z
dc.title.none.fl_str_mv Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
title Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
spellingShingle Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
Faus, Isabel
Glyphosate
GCN2
Transcriptomic
Shikimate
Translation
Herbicides
Horseweed conyza-canadensis
Sugar-beet leaves
Herbicide resistance
Vacuolar sequestration
Phosphate transporter
Gene expression
Thaliana
Stress
EIF2-alpha
Wheat
title_short Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
title_full Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
title_fullStr Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
title_full_unstemmed Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
title_sort Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
dc.creator.none.fl_str_mv Faus, Isabel
Zabalza Aznárez, Ana
Santiago, Julia
Nebauer, Sergio G.
Royuela Hernando, Mercedes
Serrano, Ramón
Gadea, José
author Faus, Isabel
author_facet Faus, Isabel
Zabalza Aznárez, Ana
Santiago, Julia
Nebauer, Sergio G.
Royuela Hernando, Mercedes
Serrano, Ramón
Gadea, José
author_role author
author2 Zabalza Aznárez, Ana
Santiago, Julia
Nebauer, Sergio G.
Royuela Hernando, Mercedes
Serrano, Ramón
Gadea, José
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias del Medio Natural
Natura Ingurunearen Zientziak
dc.subject.none.fl_str_mv Glyphosate
GCN2
Transcriptomic
Shikimate
Translation
Herbicides
Horseweed conyza-canadensis
Sugar-beet leaves
Herbicide resistance
Vacuolar sequestration
Phosphate transporter
Gene expression
Thaliana
Stress
EIF2-alpha
Wheat
topic Glyphosate
GCN2
Transcriptomic
Shikimate
Translation
Herbicides
Horseweed conyza-canadensis
Sugar-beet leaves
Herbicide resistance
Vacuolar sequestration
Phosphate transporter
Gene expression
Thaliana
Stress
EIF2-alpha
Wheat
description Incluye 7 ficheros de datos
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/18633
url https://hdl.handle.net/2454/18633
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN//BFU2011-22526
info:eu-repo/grantAgreement/MICINN//AGL2010-18621
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
http://creativecommons.org/publicdomain/zero/1.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
http://creativecommons.org/publicdomain/zero/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/zip
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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