Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties

Herein, a versatile bilayersystem, composed by a polypropylene(PP)mesh and a covalently bonded poly(N-isopropylacrylamide) (PNIPAAm) hydrogel, is reported. The cell adhesion mechanism was successfully modulated by controlling the architecture of the hydrogel in terms of duration of PNIPAAm graftingt...

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Autores: Lanzalaco, Sonia|||0000-0002-8604-5095, Valle Mendoza, Luis Javier del|||0000-0001-9916-1741, Turón Dols, Pau, Weis, Christine, Estrany Coda, Francesc|||0000-0002-2696-1489, Alemán Llansó, Carlos|||0000-0003-4462-6075, Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/174604
Acceso en línea:https://hdl.handle.net/2117/174604
https://dx.doi.org/10.1039/c9tb02537e
Access Level:acceso abierto
Palabra clave:Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria química
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repository_id_str
spelling Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion propertiesLanzalaco, Sonia|||0000-0002-8604-5095Valle Mendoza, Luis Javier del|||0000-0001-9916-1741Turón Dols, PauWeis, ChristineEstrany Coda, Francesc|||0000-0002-2696-1489Alemán Llansó, Carlos|||0000-0003-4462-6075Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696Biomedical materialsMaterials biomèdicsÀrees temàtiques de la UPC::Enginyeria químicaHerein, a versatile bilayersystem, composed by a polypropylene(PP)mesh and a covalently bonded poly(N-isopropylacrylamide) (PNIPAAm) hydrogel, is reported. The cell adhesion mechanism was successfully modulated by controlling the architecture of the hydrogel in terms of duration of PNIPAAm graftingtime, crosslinker content, and temperature of material exposure in PBS solutions (belowandabove the LCST of PNIPAAm). The best in vitroresults with fibroblast (COS-1) and epithelial (MCF-7) cells was obtained with a mesh modified with porous iPP-g-PNIPAAm bilayer system, prepared via PNIPAAm grafting for 2 h at the lowest N,N'-methylene bis(acrylamide) (MBA)concentration (1 mM). Under these conditions, the detachment of the fibroblast-like cells was 50% lower than that of the control, after 7 days of cell incubation, which represents a high de-adhesionof cellsin a short period. Moreover, the whole system showed an excellent stability in dry or wet media, proving that the thermosensitive hydrogel was well adhered to the polymer surface, after PP fibreactivation by cold plasma. This study opens new insights on the development of anti-adherent meshes for abdominal hernia repairs.Peer ReviewedRoyal Society of Chemistry (RSC)20202020-02-0720202020-01-10journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/174604https://dx.doi.org/10.1039/c9tb02537ereponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengEuropean Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 796292 4D-POLYpropylene meshes as SENsitive motion SEnsorsopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1746042026-05-27T15:37:01Z
dc.title.none.fl_str_mv Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
title Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
spellingShingle Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
Lanzalaco, Sonia|||0000-0002-8604-5095
Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria química
title_short Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
title_full Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
title_fullStr Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
title_full_unstemmed Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
title_sort Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties
dc.creator.none.fl_str_mv Lanzalaco, Sonia|||0000-0002-8604-5095
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Turón Dols, Pau
Weis, Christine
Estrany Coda, Francesc|||0000-0002-2696-1489
Alemán Llansó, Carlos|||0000-0003-4462-6075
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
author Lanzalaco, Sonia|||0000-0002-8604-5095
author_facet Lanzalaco, Sonia|||0000-0002-8604-5095
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Turón Dols, Pau
Weis, Christine
Estrany Coda, Francesc|||0000-0002-2696-1489
Alemán Llansó, Carlos|||0000-0003-4462-6075
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
author_role author
author2 Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Turón Dols, Pau
Weis, Christine
Estrany Coda, Francesc|||0000-0002-2696-1489
Alemán Llansó, Carlos|||0000-0003-4462-6075
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria química
topic Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria química
description Herein, a versatile bilayersystem, composed by a polypropylene(PP)mesh and a covalently bonded poly(N-isopropylacrylamide) (PNIPAAm) hydrogel, is reported. The cell adhesion mechanism was successfully modulated by controlling the architecture of the hydrogel in terms of duration of PNIPAAm graftingtime, crosslinker content, and temperature of material exposure in PBS solutions (belowandabove the LCST of PNIPAAm). The best in vitroresults with fibroblast (COS-1) and epithelial (MCF-7) cells was obtained with a mesh modified with porous iPP-g-PNIPAAm bilayer system, prepared via PNIPAAm grafting for 2 h at the lowest N,N'-methylene bis(acrylamide) (MBA)concentration (1 mM). Under these conditions, the detachment of the fibroblast-like cells was 50% lower than that of the control, after 7 days of cell incubation, which represents a high de-adhesionof cellsin a short period. Moreover, the whole system showed an excellent stability in dry or wet media, proving that the thermosensitive hydrogel was well adhered to the polymer surface, after PP fibreactivation by cold plasma. This study opens new insights on the development of anti-adherent meshes for abdominal hernia repairs.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-02-07
2020
2020-01-10
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/174604
https://dx.doi.org/10.1039/c9tb02537e
url https://hdl.handle.net/2117/174604
https://dx.doi.org/10.1039/c9tb02537e
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 796292 4D-POLYpropylene meshes as SENsitive motion SEnsors
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,30478

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