Deficits in nominal reference identify thought disordered speech in a narrative production task

Formal thought disorder (TD) is a neuropathology manifest in formal language dysfunction, but few behavioural linguistic studies exist. These have highlighted problems in the domain of semantics and more specifically of reference. Here we aimed for a more complete and systematic linguistic model of...

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Autores: Hinzen, Wolfram, Sevilla, Gabriel, Rosselló Ximenes, Joana, Salvador, Raymond, Sarró, Salvador, López-Araquistain, Laura, Pomarol-Clotet, Edith
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/35466
Acceso en línea:http://hdl.handle.net/10230/35466
http://dx.doi.org/10.1371/journal.pone.0201545
Access Level:acceso abierto
Palabra clave:Schizophrenia
Formal thought disorder
Language and thought
Reference
Narrative
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spelling Deficits in nominal reference identify thought disordered speech in a narrative production taskHinzen, WolframSevilla, GabrielRosselló Ximenes, JoanaSalvador, RaymondSarró, SalvadorLópez-Araquistain, LauraPomarol-Clotet, EdithSchizophreniaFormal thought disorderLanguage and thoughtReferenceNarrativeFormal thought disorder (TD) is a neuropathology manifest in formal language dysfunction, but few behavioural linguistic studies exist. These have highlighted problems in the domain of semantics and more specifically of reference. Here we aimed for a more complete and systematic linguistic model of TD, focused on (i) a more in-depth analysis of anomalies of reference as depending on the grammatical construction type in which they occur, and (ii) measures of formal grammatical complexity and errors. Narrative speech obtained from 40 patients with schizophrenia, 20 with TD and 20 without, and from 14 healthy controls matched on pre-morbid IQ, was rated blindly. Results showed that of 10 linguistic variables annotated, 4 showed significant differences between groups, including the two patient groups. These all concerned mis-uses of noun phrases (NPs) for purposes of reference, but showed sensitivity to how NPs were classed: definite and pronominal forms of reference were more affected than indefinite and non-pronominal (lexical) NPs. None of the measures of formal grammatical complexity and errors distinguished groups. We conclude that TD exhibits a specific and differentiated linguistic profile, which can illuminate TD neuro-cognitively and inform future neuroimaging studies, and can have clinical utility as a linguistic biomarker.The Grammar & Cognition Lab was supported by the Ministerio de Economía y Competitividad, Spanish Government, grants FFI2013-40526P, FFI 042177665-77665-4-16 to W.H. FIDMAG Germanes Hospitalàries Research Foundation is supported by the Agència de Gestió d'Ajuts Universitaris i de Recerca from Generalitat de Catalunya (2014-SGR-1573) and Miguel Servet Research Contract (CPII16/00018 to E. P.-C.) funded by Instituto de Salud Carlos III, co-funded by European Regional Development Fund/European Social Fund, "Investing in your future" . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Public Library of Science (PLoS)201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35466http://dx.doi.org/10.1371/journal.pone.0201545reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésPLoS ONE. 2018; 13(8): e0201545. DOI: 10.1371/journal.pone.0201545info:eu-repo/grantAgreement/ES/1PE/FFI2013-40526Pinfo:eu-repo/grantAgreement/ES/1PE/FFI2016-77647-C2-1-P© 2018 Sevilla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/354662026-06-12T07:21:37Z
dc.title.none.fl_str_mv Deficits in nominal reference identify thought disordered speech in a narrative production task
title Deficits in nominal reference identify thought disordered speech in a narrative production task
spellingShingle Deficits in nominal reference identify thought disordered speech in a narrative production task
Hinzen, Wolfram
Schizophrenia
Formal thought disorder
Language and thought
Reference
Narrative
title_short Deficits in nominal reference identify thought disordered speech in a narrative production task
title_full Deficits in nominal reference identify thought disordered speech in a narrative production task
title_fullStr Deficits in nominal reference identify thought disordered speech in a narrative production task
title_full_unstemmed Deficits in nominal reference identify thought disordered speech in a narrative production task
title_sort Deficits in nominal reference identify thought disordered speech in a narrative production task
dc.creator.none.fl_str_mv Hinzen, Wolfram
Sevilla, Gabriel
Rosselló Ximenes, Joana
Salvador, Raymond
Sarró, Salvador
López-Araquistain, Laura
Pomarol-Clotet, Edith
author Hinzen, Wolfram
author_facet Hinzen, Wolfram
Sevilla, Gabriel
Rosselló Ximenes, Joana
Salvador, Raymond
Sarró, Salvador
López-Araquistain, Laura
Pomarol-Clotet, Edith
author_role author
author2 Sevilla, Gabriel
Rosselló Ximenes, Joana
Salvador, Raymond
Sarró, Salvador
López-Araquistain, Laura
Pomarol-Clotet, Edith
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Schizophrenia
Formal thought disorder
Language and thought
Reference
Narrative
topic Schizophrenia
Formal thought disorder
Language and thought
Reference
Narrative
description Formal thought disorder (TD) is a neuropathology manifest in formal language dysfunction, but few behavioural linguistic studies exist. These have highlighted problems in the domain of semantics and more specifically of reference. Here we aimed for a more complete and systematic linguistic model of TD, focused on (i) a more in-depth analysis of anomalies of reference as depending on the grammatical construction type in which they occur, and (ii) measures of formal grammatical complexity and errors. Narrative speech obtained from 40 patients with schizophrenia, 20 with TD and 20 without, and from 14 healthy controls matched on pre-morbid IQ, was rated blindly. Results showed that of 10 linguistic variables annotated, 4 showed significant differences between groups, including the two patient groups. These all concerned mis-uses of noun phrases (NPs) for purposes of reference, but showed sensitivity to how NPs were classed: definite and pronominal forms of reference were more affected than indefinite and non-pronominal (lexical) NPs. None of the measures of formal grammatical complexity and errors distinguished groups. We conclude that TD exhibits a specific and differentiated linguistic profile, which can illuminate TD neuro-cognitively and inform future neuroimaging studies, and can have clinical utility as a linguistic biomarker.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35466
http://dx.doi.org/10.1371/journal.pone.0201545
url http://hdl.handle.net/10230/35466
http://dx.doi.org/10.1371/journal.pone.0201545
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS ONE. 2018; 13(8): e0201545. DOI: 10.1371/journal.pone.0201545
info:eu-repo/grantAgreement/ES/1PE/FFI2013-40526P
info:eu-repo/grantAgreement/ES/1PE/FFI2016-77647-C2-1-P
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
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