Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia

Background. Malaria “hotspots” have been proposed as potential intervention units for targeted malaria elimination. Little is known about hotspot formation and stability in settings outside sub-Saharan Africa. Methods. Clustering of Plasmodium infections at the household and hotspot level was assess...

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Autores: Bannister-Tyrrell, Melanie, Krit, Meryam, Sluydts, Vincent, Tho, Sochantha, Sokny, Mao, Mean, Vanna, Kim, Saorin, Ménard, Didier, Grietens, Koen Peeters, Abrams, Steven, Hens, Niel, Coosemans, Marc, Bassat Orellana, Quique, Boele van Hensbroek, Michael, Durnez, Lies, Van Bortel, Wim
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/138998
Acceso en línea:https://hdl.handle.net/2445/138998
Access Level:acceso abierto
Palabra clave:Malària
Epidemiologia
Cambodja
Malaria
Epidemiology
Cambodia
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spelling Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern CambodiaBannister-Tyrrell, MelanieKrit, MeryamSluydts, VincentTho, SochanthaSokny, MaoMean, VannaKim, SaorinMénard, DidierGrietens, Koen PeetersAbrams, StevenHens, NielCoosemans, MarcBassat Orellana, QuiqueBoele van Hensbroek, MichaelDurnez, LiesVan Bortel, WimMalàriaEpidemiologiaCambodjaMalariaEpidemiologyCambodiaBackground. Malaria “hotspots” have been proposed as potential intervention units for targeted malaria elimination. Little is known about hotspot formation and stability in settings outside sub-Saharan Africa. Methods. Clustering of Plasmodium infections at the household and hotspot level was assessed over 2 years in 3 villages in eastern Cambodia. Social and spatial autocorrelation statistics were calculated to assess clustering of malaria risk, and logistic regression was used to assess the effect of living in a malaria hotspot compared to living in a malaria-positive household in the first year of the study on risk of malaria infection in the second year. Results. The crude prevalence of Plasmodium infection was 8.4% in 2016 and 3.6% in 2017. Living in a hotspot in 2016 did not predict Plasmodium risk at the individual or household level in 2017 overall, but living in a Plasmodium-positive household in 2016 strongly predicted living in a Plasmodium-positive household in 2017 (Risk Ratio, 5.00 [95% confidence interval, 2.09–11.96], P < .0001). There was no consistent evidence that malaria risk clustered in groups of socially connected individuals from different households. Conclusions. Malaria risk clustered more clearly in households than in hotspots over 2 years. Household-based strategies should be prioritized in malaria elimination programs in this region.Oxford University Press2019info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/138998Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1093/infdis/jiz211Journal of Infectious Diseases, 2019http://dx.doi.org/10.1093/infdis/jiz211cc by-nc-nd (c) Bannister-Tyrrell et al., 2019http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1389982026-05-27T06:46:51Z
dc.title.none.fl_str_mv Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia
title Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia
spellingShingle Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia
Bannister-Tyrrell, Melanie
Malària
Epidemiologia
Cambodja
Malaria
Epidemiology
Cambodia
title_short Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia
title_full Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia
title_fullStr Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia
title_full_unstemmed Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia
title_sort Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia
dc.creator.none.fl_str_mv Bannister-Tyrrell, Melanie
Krit, Meryam
Sluydts, Vincent
Tho, Sochantha
Sokny, Mao
Mean, Vanna
Kim, Saorin
Ménard, Didier
Grietens, Koen Peeters
Abrams, Steven
Hens, Niel
Coosemans, Marc
Bassat Orellana, Quique
Boele van Hensbroek, Michael
Durnez, Lies
Van Bortel, Wim
author Bannister-Tyrrell, Melanie
author_facet Bannister-Tyrrell, Melanie
Krit, Meryam
Sluydts, Vincent
Tho, Sochantha
Sokny, Mao
Mean, Vanna
Kim, Saorin
Ménard, Didier
Grietens, Koen Peeters
Abrams, Steven
Hens, Niel
Coosemans, Marc
Bassat Orellana, Quique
Boele van Hensbroek, Michael
Durnez, Lies
Van Bortel, Wim
author_role author
author2 Krit, Meryam
Sluydts, Vincent
Tho, Sochantha
Sokny, Mao
Mean, Vanna
Kim, Saorin
Ménard, Didier
Grietens, Koen Peeters
Abrams, Steven
Hens, Niel
Coosemans, Marc
Bassat Orellana, Quique
Boele van Hensbroek, Michael
Durnez, Lies
Van Bortel, Wim
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malària
Epidemiologia
Cambodja
Malaria
Epidemiology
Cambodia
topic Malària
Epidemiologia
Cambodja
Malaria
Epidemiology
Cambodia
description Background. Malaria “hotspots” have been proposed as potential intervention units for targeted malaria elimination. Little is known about hotspot formation and stability in settings outside sub-Saharan Africa. Methods. Clustering of Plasmodium infections at the household and hotspot level was assessed over 2 years in 3 villages in eastern Cambodia. Social and spatial autocorrelation statistics were calculated to assess clustering of malaria risk, and logistic regression was used to assess the effect of living in a malaria hotspot compared to living in a malaria-positive household in the first year of the study on risk of malaria infection in the second year. Results. The crude prevalence of Plasmodium infection was 8.4% in 2016 and 3.6% in 2017. Living in a hotspot in 2016 did not predict Plasmodium risk at the individual or household level in 2017 overall, but living in a Plasmodium-positive household in 2016 strongly predicted living in a Plasmodium-positive household in 2017 (Risk Ratio, 5.00 [95% confidence interval, 2.09–11.96], P < .0001). There was no consistent evidence that malaria risk clustered in groups of socially connected individuals from different households. Conclusions. Malaria risk clustered more clearly in households than in hotspots over 2 years. Household-based strategies should be prioritized in malaria elimination programs in this region.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/138998
url https://hdl.handle.net/2445/138998
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1093/infdis/jiz211
Journal of Infectious Diseases, 2019
http://dx.doi.org/10.1093/infdis/jiz211
dc.rights.none.fl_str_mv cc by-nc-nd (c) Bannister-Tyrrell et al., 2019
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Bannister-Tyrrell et al., 2019
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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