Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease

© 2016 The Author(s).

Bibliographic Details
Authors: Lamas, Adelaida, Marshburn, Jamie, Stober, Vandy P., Donaldson, Scott H., Garantziotis, Stavros
Format: article
Status:Published version
Publication Date:2016
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/199826
Online Access:http://hdl.handle.net/10261/199826
Access Level:Open access
Keyword:Cystic fibrosis
Hyaluronan
Airway inflammation
Induced sputum
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spelling Effects of inhaled high-molecular weight hyaluronan in inflammatory airway diseaseLamas, AdelaidaMarshburn, JamieStober, Vandy P.Donaldson, Scott H.Garantziotis, StavrosCystic fibrosisHyaluronanAirway inflammationInduced sputum© 2016 The Author(s).Cystic fibrosis (CF) is a chronic inflammatory disease that is affecting thousands of patients worldwide. Adjuvant anti-inflammatory treatment is an important component of cystic fibrosis treatment, and has shown promise in preserving lung function and prolonging life expectancy. Inhaled high molecular weight hyaluronan (HMW-HA) is reported to improve tolerability of hypertonic saline and thus increase compliance, and has been approved in some European countries for use as an adjunct to hypertonic saline treatment in cystic fibrosis. However, there are theoretical concerns that HMW-HA breakdown products may be pro-inflammatory. In this clinical pilot study we show that sputum cytokines in CF patients receiving HMW-HA are not increased, and therefore HMW-HA does not appear to adversely affect inflammatory status in CF airways.This work was funded by the Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health.BioMed CentralNational Institute of Environmental Health Sciences (US)National Institutes of Health (US)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020162020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_545bPublisher's versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/contributionToPeriodicalhttp://hdl.handle.net/10261/199826reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1186/s12931-016-0442-4Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1998262026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
title Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
spellingShingle Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
Lamas, Adelaida
Cystic fibrosis
Hyaluronan
Airway inflammation
Induced sputum
title_short Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
title_full Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
title_fullStr Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
title_full_unstemmed Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
title_sort Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
dc.creator.none.fl_str_mv Lamas, Adelaida
Marshburn, Jamie
Stober, Vandy P.
Donaldson, Scott H.
Garantziotis, Stavros
author Lamas, Adelaida
author_facet Lamas, Adelaida
Marshburn, Jamie
Stober, Vandy P.
Donaldson, Scott H.
Garantziotis, Stavros
author_role author
author2 Marshburn, Jamie
Stober, Vandy P.
Donaldson, Scott H.
Garantziotis, Stavros
author2_role author
author
author
author
dc.contributor.none.fl_str_mv National Institute of Environmental Health Sciences (US)
National Institutes of Health (US)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cystic fibrosis
Hyaluronan
Airway inflammation
Induced sputum
topic Cystic fibrosis
Hyaluronan
Airway inflammation
Induced sputum
description © 2016 The Author(s).
publishDate 2016
dc.date.none.fl_str_mv 2016
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_545b
Publisher's version
info:eu-repo/semantics/publishedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/contributionToPeriodical
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/199826
url http://hdl.handle.net/10261/199826
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1186/s12931-016-0442-4
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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