Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics

Background: To evaluate changes in the effectiveness of phentolamine mesylate in combination with different local anesthetics (LAs) and vasoconstrictors. A prospective randomized double-blind study was conducted with 90 patients divided into three groups, with each group being administered one of th...

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Autores: Gago García, Alejandro, Barrilero Martín, Cayetana, Alobera Gracia, Miguel Ángel, Del Canto Pingarrón, Mariano, Seco Calvo, Jesús Ángel
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/50661
Acesso em linha:http://hdl.handle.net/10810/50661
Access Level:acceso abierto
Palavra-chave:articaine
bupivacaine
epinephrine
lidocaine
local anesthesia
phentolamine mesylate
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spelling Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local AnestheticsGago García, AlejandroBarrilero Martín, CayetanaAlobera Gracia, Miguel ÁngelDel Canto Pingarrón, MarianoSeco Calvo, Jesús Ángelarticainebupivacaineepinephrinelidocainelocal anesthesiaphentolamine mesylateBackground: To evaluate changes in the effectiveness of phentolamine mesylate in combination with different local anesthetics (LAs) and vasoconstrictors. A prospective randomized double-blind study was conducted with 90 patients divided into three groups, with each group being administered one of three different LAs: lidocaine 2% 1/80,000, articaine 4% 1/200,000, and bupivacaine 0.5% 1/200,000. Methods: We compared treatments administered to the mandible involving a LA blockade of the inferior alveolar nerve. Results were assessed by evaluating reduction in total duration of anesthesia, self-reported patient comfort using the visual analog pain scale, incidence rates of the most common adverse effects, overall patient satisfaction, and patient feedback. Results: The differences among the three groups were highly significant (P < 0.001); time under anesthesia was especially reduced for both the lip and tongue with bupivacaine. The following adverse effects were reported: pain at the site of the anesthetic injection (11.1%), headaches (6.7%), tachycardia (1.1%), and heavy bleeding after treatment (3.3%). The patients' feedback and satisfaction ratings were 100% and 98.9%, respectively. Conclusions: Efficient reversal of LAs is useful in dentistry as it allows patients to return to normal life more readily and avoid common self-injuries sometimes caused by anesthesia. Phentolamine mesylate reduced the duration of anesthesia in the three studied groups, with the highest reduction reported in the bupivacaine group (from 460 min to 230 min for the lip and 270 min for the tongue [P < 0.001])Manager202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/50661reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://jdapm.org/DOIx.php?id=10.17245/jdapm.2021.21.1.49info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/3.0/es/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0)Atribución-NoComercial 3.0 Españaoai:addi.ehu.eus:10810/506612026-06-18T09:23:17Z
dc.title.none.fl_str_mv Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics
title Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics
spellingShingle Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics
Gago García, Alejandro
articaine
bupivacaine
epinephrine
lidocaine
local anesthesia
phentolamine mesylate
title_short Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics
title_full Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics
title_fullStr Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics
title_full_unstemmed Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics
title_sort Efficacy of Phentolamine Mesylate in Reducing the Duration of Various Local Anesthetics
dc.creator.none.fl_str_mv Gago García, Alejandro
Barrilero Martín, Cayetana
Alobera Gracia, Miguel Ángel
Del Canto Pingarrón, Mariano
Seco Calvo, Jesús Ángel
author Gago García, Alejandro
author_facet Gago García, Alejandro
Barrilero Martín, Cayetana
Alobera Gracia, Miguel Ángel
Del Canto Pingarrón, Mariano
Seco Calvo, Jesús Ángel
author_role author
author2 Barrilero Martín, Cayetana
Alobera Gracia, Miguel Ángel
Del Canto Pingarrón, Mariano
Seco Calvo, Jesús Ángel
author2_role author
author
author
author
dc.subject.none.fl_str_mv articaine
bupivacaine
epinephrine
lidocaine
local anesthesia
phentolamine mesylate
topic articaine
bupivacaine
epinephrine
lidocaine
local anesthesia
phentolamine mesylate
description Background: To evaluate changes in the effectiveness of phentolamine mesylate in combination with different local anesthetics (LAs) and vasoconstrictors. A prospective randomized double-blind study was conducted with 90 patients divided into three groups, with each group being administered one of three different LAs: lidocaine 2% 1/80,000, articaine 4% 1/200,000, and bupivacaine 0.5% 1/200,000. Methods: We compared treatments administered to the mandible involving a LA blockade of the inferior alveolar nerve. Results were assessed by evaluating reduction in total duration of anesthesia, self-reported patient comfort using the visual analog pain scale, incidence rates of the most common adverse effects, overall patient satisfaction, and patient feedback. Results: The differences among the three groups were highly significant (P < 0.001); time under anesthesia was especially reduced for both the lip and tongue with bupivacaine. The following adverse effects were reported: pain at the site of the anesthetic injection (11.1%), headaches (6.7%), tachycardia (1.1%), and heavy bleeding after treatment (3.3%). The patients' feedback and satisfaction ratings were 100% and 98.9%, respectively. Conclusions: Efficient reversal of LAs is useful in dentistry as it allows patients to return to normal life more readily and avoid common self-injuries sometimes caused by anesthesia. Phentolamine mesylate reduced the duration of anesthesia in the three studied groups, with the highest reduction reported in the bupivacaine group (from 460 min to 230 min for the lip and 270 min for the tongue [P < 0.001])
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/50661
url http://hdl.handle.net/10810/50661
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://jdapm.org/DOIx.php?id=10.17245/jdapm.2021.21.1.49
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/3.0/es/
Atribución-NoComercial 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/3.0/es/
Atribución-NoComercial 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Manager
publisher.none.fl_str_mv Manager
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
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repository.mail.fl_str_mv
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