Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.

The ability of environmental cues to trigger alcohol-seeking behaviours is thought to facilitate problematic alcohol use. Individuals' tendency to attribute incentive salience to cues may increase the risk of addiction. We sought to study the relationship between incentive salience and alcohol...

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Authors: Hakus, Aileen, Foo, Jerome Clifford, Casquero-Veiga, Marta, Gül, Asude Zülal, Hintz, Franziska, Rivalan, Marion, Winter, York, Priller, Josef, Hadar, Ravit, Winter, Christine
Format: article
Publication Date:2025
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/26752
Online Access:https://hdl.handle.net/20.500.12105/26752
Access Level:Open access
Keyword:Pavlovian conditioned approach
alcohol addiction
alcohol deprivation effect model
goal tracker
incentive salience
sign‐tracker
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spelling Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.Hakus, AileenFoo, Jerome CliffordCasquero-Veiga, MartaGül, Asude ZülalHintz, FranziskaRivalan, MarionWinter, YorkPriller, JosefHadar, RavitWinter, ChristinePavlovian conditioned approachalcohol addictionalcohol deprivation effect modelgoal trackerincentive saliencesign‐trackerThe ability of environmental cues to trigger alcohol-seeking behaviours is thought to facilitate problematic alcohol use. Individuals' tendency to attribute incentive salience to cues may increase the risk of addiction. We sought to study the relationship between incentive salience and alcohol addiction using non-preferring rats to model the heterogeneity of human alcohol consumption, investigating both males and females. Adult rats were subjected to the alcohol deprivation effect (ADE) paradigm, where they were given voluntary access to different alcohol solutions with repeated interruptions by deprivation and reintroduction phases over a protracted period (five Alcohol Deprivation Cycles). Before each Alcohol Deprivation Cycle, rats were tested in the Pavlovian Conditioned Approach (PCA) paradigm, which quantifies the individual salience toward a conditional cue and the reward, thus allowing us to trace the process of attributing incentive salience to reward cues. During the final Alcohol Deprivation Cycle (ADE5), animals were tested for compulsive-like behaviour using quinine taste adulteration. We investigated sex differences in drinking behaviour and PCA performance. We observed thatb females drank significantly more alcohol than males and displayed more sign-tracking (ST) behaviour in the PCA, whereas males showed goal-tracking (GT) behaviour. Furthermore, we found that high drinkers exhibited more ST behaviour. The initial PCA phenotype was correlated with later alcohol consumption. Our findings indicate a complex relationship between incentive salience and alcohol addiction and emphasize the importance of considering both sexes in preclinical research.Wiley20252025-06-1620252025-01-0120252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12105/26752reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/267522026-06-12T12:43:37Z
dc.title.none.fl_str_mv Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
title Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
spellingShingle Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
Hakus, Aileen
Pavlovian conditioned approach
alcohol addiction
alcohol deprivation effect model
goal tracker
incentive salience
sign‐tracker
title_short Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
title_full Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
title_fullStr Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
title_full_unstemmed Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
title_sort Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
dc.creator.none.fl_str_mv Hakus, Aileen
Foo, Jerome Clifford
Casquero-Veiga, Marta
Gül, Asude Zülal
Hintz, Franziska
Rivalan, Marion
Winter, York
Priller, Josef
Hadar, Ravit
Winter, Christine
author Hakus, Aileen
author_facet Hakus, Aileen
Foo, Jerome Clifford
Casquero-Veiga, Marta
Gül, Asude Zülal
Hintz, Franziska
Rivalan, Marion
Winter, York
Priller, Josef
Hadar, Ravit
Winter, Christine
author_role author
author2 Foo, Jerome Clifford
Casquero-Veiga, Marta
Gül, Asude Zülal
Hintz, Franziska
Rivalan, Marion
Winter, York
Priller, Josef
Hadar, Ravit
Winter, Christine
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Pavlovian conditioned approach
alcohol addiction
alcohol deprivation effect model
goal tracker
incentive salience
sign‐tracker
topic Pavlovian conditioned approach
alcohol addiction
alcohol deprivation effect model
goal tracker
incentive salience
sign‐tracker
description The ability of environmental cues to trigger alcohol-seeking behaviours is thought to facilitate problematic alcohol use. Individuals' tendency to attribute incentive salience to cues may increase the risk of addiction. We sought to study the relationship between incentive salience and alcohol addiction using non-preferring rats to model the heterogeneity of human alcohol consumption, investigating both males and females. Adult rats were subjected to the alcohol deprivation effect (ADE) paradigm, where they were given voluntary access to different alcohol solutions with repeated interruptions by deprivation and reintroduction phases over a protracted period (five Alcohol Deprivation Cycles). Before each Alcohol Deprivation Cycle, rats were tested in the Pavlovian Conditioned Approach (PCA) paradigm, which quantifies the individual salience toward a conditional cue and the reward, thus allowing us to trace the process of attributing incentive salience to reward cues. During the final Alcohol Deprivation Cycle (ADE5), animals were tested for compulsive-like behaviour using quinine taste adulteration. We investigated sex differences in drinking behaviour and PCA performance. We observed thatb females drank significantly more alcohol than males and displayed more sign-tracking (ST) behaviour in the PCA, whereas males showed goal-tracking (GT) behaviour. Furthermore, we found that high drinkers exhibited more ST behaviour. The initial PCA phenotype was correlated with later alcohol consumption. Our findings indicate a complex relationship between incentive salience and alcohol addiction and emphasize the importance of considering both sexes in preclinical research.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-06-16
2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/26752
url https://hdl.handle.net/20.500.12105/26752
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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