Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol

Scaffolds constituted by electrospun microfibers of poly(ethylene glycol) (PEG) and poly(butylene succinate) (PBS) were studied. Specifically, coaxial microfibers having different core-shell distributions and compositions were considered as well as uniaxial micro/nanofibers prepared from mixtures of...

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Detalles Bibliográficos
Autores: Llorens, E., Ibañez, H, Valle Mendoza, Luis Javier del|||0000-0001-9916-1741, Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/85886
Acceso en línea:https://hdl.handle.net/2117/85886
https://dx.doi.org/10.1016/j.msec.2015.01.039
Access Level:acceso abierto
Palabra clave:Polymers
Scaffolds
Coaxial electrospinning
Poly(butylene succinate)
Poly(ethylene glycol)
Drug release
polymer nanofibers
fibers
polylactide
delivery
morphology
mixtures
surfaces
curcumin
Polímers
Àrees temàtiques de la UPC::Enginyeria química
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repository_id_str
spelling Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycolLlorens, E.Ibañez, HValle Mendoza, Luis Javier del|||0000-0001-9916-1741Puiggalí Bellalta, Jordi|||0000-0002-0640-4474PolymersScaffoldsCoaxial electrospinningPoly(butylene succinate)Poly(ethylene glycol)Drug releasepolymer nanofibersfiberspolylactidedeliverymorphologymixturessurfacescurcuminPolímersÀrees temàtiques de la UPC::Enginyeria químicaScaffolds constituted by electrospun microfibers of poly(ethylene glycol) (PEG) and poly(butylene succinate) (PBS) were studied. Specifically, coaxial microfibers having different core-shell distributions and compositions were considered as well as uniaxial micro/nanofibers prepared from mixtures of both polymers. Processing conditions were optimized for all geometries and compositions and resulting morphologies (i.e. diameter and surface texture) characterized by scanning electron microscopy. Chemical composition, molecular interactions and thermal properties were evaluated by FTIR, NMR, XPS and differential scanning calorimetry. The PEG component of electrospun fibers could be solubilized by immersion of scaffolds in aqueous medium, giving rise to high porosity and hydrophobic samples. Nevertheless, a small amount of PEG was retained in the PBS matrix, suggesting some degree of mixing. Solubilization was slightly dependent on fiber structure: specifically, the distribution of PEG in the core or shell of coaxial fibers led to higher or lower retention levels, respectively. Scaffolds could be effectively loaded with hydrophobic drugs having antibacterial and anticarcinogenic activities like triclosan and curcumin, respectively. Their release was highly dependent on their chemical structure and medium composition. Thus, low and high release rates were observed in phosphate buffer saline (SS) and SS/ethanol (30:70 v/v), respectively. Slight differences in the release of triclosan were found depending on fiber distribution and composition. Antibacterial activity and biocompatibility were evaluated for both loaded and unloaded scaffolds. (C) 2015 Elsevier B.V. All rights reserved.Peer Reviewed20152015-04-0120162016-04-19journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/mswordhttps://hdl.handle.net/2117/85886https://dx.doi.org/10.1016/j.msec.2015.01.039reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/858862026-05-27T15:37:01Z
dc.title.none.fl_str_mv Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol
title Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol
spellingShingle Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol
Llorens, E.
Polymers
Scaffolds
Coaxial electrospinning
Poly(butylene succinate)
Poly(ethylene glycol)
Drug release
polymer nanofibers
fibers
polylactide
delivery
morphology
mixtures
surfaces
curcumin
Polímers
Àrees temàtiques de la UPC::Enginyeria química
title_short Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol
title_full Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol
title_fullStr Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol
title_full_unstemmed Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol
title_sort Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol
dc.creator.none.fl_str_mv Llorens, E.
Ibañez, H
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author Llorens, E.
author_facet Llorens, E.
Ibañez, H
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author_role author
author2 Ibañez, H
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author2_role author
author
author
dc.subject.none.fl_str_mv Polymers
Scaffolds
Coaxial electrospinning
Poly(butylene succinate)
Poly(ethylene glycol)
Drug release
polymer nanofibers
fibers
polylactide
delivery
morphology
mixtures
surfaces
curcumin
Polímers
Àrees temàtiques de la UPC::Enginyeria química
topic Polymers
Scaffolds
Coaxial electrospinning
Poly(butylene succinate)
Poly(ethylene glycol)
Drug release
polymer nanofibers
fibers
polylactide
delivery
morphology
mixtures
surfaces
curcumin
Polímers
Àrees temàtiques de la UPC::Enginyeria química
description Scaffolds constituted by electrospun microfibers of poly(ethylene glycol) (PEG) and poly(butylene succinate) (PBS) were studied. Specifically, coaxial microfibers having different core-shell distributions and compositions were considered as well as uniaxial micro/nanofibers prepared from mixtures of both polymers. Processing conditions were optimized for all geometries and compositions and resulting morphologies (i.e. diameter and surface texture) characterized by scanning electron microscopy. Chemical composition, molecular interactions and thermal properties were evaluated by FTIR, NMR, XPS and differential scanning calorimetry. The PEG component of electrospun fibers could be solubilized by immersion of scaffolds in aqueous medium, giving rise to high porosity and hydrophobic samples. Nevertheless, a small amount of PEG was retained in the PBS matrix, suggesting some degree of mixing. Solubilization was slightly dependent on fiber structure: specifically, the distribution of PEG in the core or shell of coaxial fibers led to higher or lower retention levels, respectively. Scaffolds could be effectively loaded with hydrophobic drugs having antibacterial and anticarcinogenic activities like triclosan and curcumin, respectively. Their release was highly dependent on their chemical structure and medium composition. Thus, low and high release rates were observed in phosphate buffer saline (SS) and SS/ethanol (30:70 v/v), respectively. Slight differences in the release of triclosan were found depending on fiber distribution and composition. Antibacterial activity and biocompatibility were evaluated for both loaded and unloaded scaffolds. (C) 2015 Elsevier B.V. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-04-01
2016
2016-04-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/85886
https://dx.doi.org/10.1016/j.msec.2015.01.039
url https://hdl.handle.net/2117/85886
https://dx.doi.org/10.1016/j.msec.2015.01.039
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/msword
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420210026446848
score 15.301603

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