Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats

Abstract References Supplementary Material Get access Cite article Share options Information, rights and permissions Metrics and citations Abstract Background: Enhancement in cognitive impulsivity and the resulting alterations in decision making serve as a contributing factor for the development and...

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Detalles Bibliográficos
Autores: Nazarian, Arbi, Ibias Martín, Javier
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Nacional de Educación a Distancia
Repositorio:e-spacio. Repositorio Institucional de la UNED
Idioma:inglés
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/12625
Acceso en línea:https://hdl.handle.net/20.500.14468/12625
Access Level:acceso abierto
Palabra clave:Nicotine
delay discounting
impulsivity
sex differences
bupropion
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spelling Sex differences in nicotine-induced impulsivity and its reversal with bupropion in ratsNazarian, ArbiIbias Martín, JavierNicotinedelay discountingimpulsivitysex differencesbupropionAbstract References Supplementary Material Get access Cite article Share options Information, rights and permissions Metrics and citations Abstract Background: Enhancement in cognitive impulsivity and the resulting alterations in decision making serve as a contributing factor for the development and maintenance of substance-use disorders. Nicotine-induced increases in impulsivity has been previously reported in male humans and rodents. Although the potential for sex differences in nicotine-induced impulsivity has not been examined. Aims and methods: In the present study, male and female Sprague Dawley rats were submitted to a delay discounting task, in which several consecutive measures of self-control were taken. Firstly, rats were tested with vehicle, and next with nicotine doses of 0.4 and 0.8 mg/kg. Thereafter, chronic treatment with bupropion started, and the animals were tested again. Half the animals continued to receive 0.8 mg/kg of nicotine, while the rest received nicotine and also a daily dose of 30 mg/kg of bupropion. Results: When the animals were first tested with nicotine, female rats showed a significant nicotine dose dependent increase of impulsive behaviour, whereas male rats only showed a decrease on their elections of the larger but delayed reward under the highest dose of 0.8 mg/kg of nicotine. Treatment with bupropion blocked the effect of nicotine on decision making in female rats, as they showed results close to their baseline levels. On the other hand, bupropion did not affect the nicotine-induced delay discounting in male rats. Conclusion: These findings demonstrate sexually dimorphic effects of nicotine on cognitive impulsivity which may help to shed light on nicotine use vulnerabilities observed in women.SAGEe-Spacio UNED20242024-05-2020202020-12-0120202020-12-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/12625reponame:e-spacio. Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/126252026-06-06T12:38:31Z
dc.title.none.fl_str_mv Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
title Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
spellingShingle Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
Nazarian, Arbi
Nicotine
delay discounting
impulsivity
sex differences
bupropion
title_short Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
title_full Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
title_fullStr Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
title_full_unstemmed Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
title_sort Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
dc.creator.none.fl_str_mv Nazarian, Arbi
Ibias Martín, Javier
author Nazarian, Arbi
author_facet Nazarian, Arbi
Ibias Martín, Javier
author_role author
author2 Ibias Martín, Javier
author2_role author
dc.contributor.none.fl_str_mv e-Spacio UNED
dc.subject.none.fl_str_mv Nicotine
delay discounting
impulsivity
sex differences
bupropion
topic Nicotine
delay discounting
impulsivity
sex differences
bupropion
description Abstract References Supplementary Material Get access Cite article Share options Information, rights and permissions Metrics and citations Abstract Background: Enhancement in cognitive impulsivity and the resulting alterations in decision making serve as a contributing factor for the development and maintenance of substance-use disorders. Nicotine-induced increases in impulsivity has been previously reported in male humans and rodents. Although the potential for sex differences in nicotine-induced impulsivity has not been examined. Aims and methods: In the present study, male and female Sprague Dawley rats were submitted to a delay discounting task, in which several consecutive measures of self-control were taken. Firstly, rats were tested with vehicle, and next with nicotine doses of 0.4 and 0.8 mg/kg. Thereafter, chronic treatment with bupropion started, and the animals were tested again. Half the animals continued to receive 0.8 mg/kg of nicotine, while the rest received nicotine and also a daily dose of 30 mg/kg of bupropion. Results: When the animals were first tested with nicotine, female rats showed a significant nicotine dose dependent increase of impulsive behaviour, whereas male rats only showed a decrease on their elections of the larger but delayed reward under the highest dose of 0.8 mg/kg of nicotine. Treatment with bupropion blocked the effect of nicotine on decision making in female rats, as they showed results close to their baseline levels. On the other hand, bupropion did not affect the nicotine-induced delay discounting in male rats. Conclusion: These findings demonstrate sexually dimorphic effects of nicotine on cognitive impulsivity which may help to shed light on nicotine use vulnerabilities observed in women.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-12-01
2020
2020-12-01
2024
2024-05-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14468/12625
url https://hdl.handle.net/20.500.14468/12625
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE
publisher.none.fl_str_mv SAGE
dc.source.none.fl_str_mv reponame:e-spacio. Repositorio Institucional de la UNED
instname:Universidad Nacional de Educación a Distancia
instname_str Universidad Nacional de Educación a Distancia
reponame_str e-spacio. Repositorio Institucional de la UNED
collection e-spacio. Repositorio Institucional de la UNED
repository.name.fl_str_mv
repository.mail.fl_str_mv
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