Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations

The predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk to identify novel markers that might complement current estima...

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Autores: Martínez, Paula J., Agudiez, Marta, Molero, Dolores, Martín Lorenzo, Marta, Baldán Martín, Montserrat, Santiago Hernández, Aranzazu, García Segura, Juan Manuel, Madruga, Felipe, Cabrera, Martha, Ruilope Urioste, Luis Miguel, Et al.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/9619
Acceso en línea:http://hdl.handle.net/11268/9619
Access Level:acceso abierto
Palabra clave:Metabolismo
Ancianos
Aparato urinario
Anciano
Sistema cardiovascular
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spelling Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populationsMartínez, Paula J.Agudiez, MartaMolero, DoloresMartín Lorenzo, MartaBaldán Martín, MontserratSantiago Hernández, AranzazuGarcía Segura, Juan ManuelMadruga, FelipeCabrera, MarthaRuilope Urioste, Luis MiguelEt al.MetabolismoAncianosAparato urinarioMetabolismoAncianoSistema cardiovascularThe predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk to identify novel markers that might complement current estimators based on age. Urine samples were collected from 234 subjects categorized into three age-grouped cohorts: 30–50 years (cohort I, young), 50–70 years (cohort II, middle-aged), and > 70 years (cohort III, elderly). Each cohort was further classified into three groups: (a) control, (b) individuals with cardiovascular risk factors, and (c) those who had a previous cardiovascular event. Novel urinary metabolites linked to cardiovascular risk were identified by nuclear magnetic resonance in cohort I and then evaluated by target mass spectrometry quantification in all cohorts. A previously identified metabolic fingerprint associated with atherosclerosis was also analyzed and its potential risk estimation investigated in the three aged cohorts. Three different metabolic signatures were identified according to age: 2-hydroxybutyrate, gamma-aminobutyric acid, hypoxanthine, guanidoacetate, oxaloacetate, and serine in young adults; citrate, cyclohexanol, glutamine, lysine, pantothenate, pipecolate, threonine, and tyramine shared by middle-aged and elderly adults; and trimethylamine N-oxide and glucuronate associated with cardiovascular risk in all three cohorts. The urinary metabolome contains a metabolic signature of cardiovascular risk that differs across age groups. These signatures might serve to complement existing algorithms and improve the accuracy of cardiovascular risk prediction for personalized prevention.20212021-01-1120202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articlehttp://hdl.handle.net/11268/9619reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/96192026-06-11T12:41:27Z
dc.title.none.fl_str_mv Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
title Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
spellingShingle Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
Martínez, Paula J.
Metabolismo
Ancianos
Aparato urinario
Metabolismo
Anciano
Sistema cardiovascular
title_short Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
title_full Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
title_fullStr Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
title_full_unstemmed Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
title_sort Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
dc.creator.none.fl_str_mv Martínez, Paula J.
Agudiez, Marta
Molero, Dolores
Martín Lorenzo, Marta
Baldán Martín, Montserrat
Santiago Hernández, Aranzazu
García Segura, Juan Manuel
Madruga, Felipe
Cabrera, Martha
Ruilope Urioste, Luis Miguel
Et al.
author Martínez, Paula J.
author_facet Martínez, Paula J.
Agudiez, Marta
Molero, Dolores
Martín Lorenzo, Marta
Baldán Martín, Montserrat
Santiago Hernández, Aranzazu
García Segura, Juan Manuel
Madruga, Felipe
Cabrera, Martha
Ruilope Urioste, Luis Miguel
Et al.
author_role author
author2 Agudiez, Marta
Molero, Dolores
Martín Lorenzo, Marta
Baldán Martín, Montserrat
Santiago Hernández, Aranzazu
García Segura, Juan Manuel
Madruga, Felipe
Cabrera, Martha
Ruilope Urioste, Luis Miguel
Et al.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Metabolismo
Ancianos
Aparato urinario
Metabolismo
Anciano
Sistema cardiovascular
topic Metabolismo
Ancianos
Aparato urinario
Metabolismo
Anciano
Sistema cardiovascular
description The predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk to identify novel markers that might complement current estimators based on age. Urine samples were collected from 234 subjects categorized into three age-grouped cohorts: 30–50 years (cohort I, young), 50–70 years (cohort II, middle-aged), and > 70 years (cohort III, elderly). Each cohort was further classified into three groups: (a) control, (b) individuals with cardiovascular risk factors, and (c) those who had a previous cardiovascular event. Novel urinary metabolites linked to cardiovascular risk were identified by nuclear magnetic resonance in cohort I and then evaluated by target mass spectrometry quantification in all cohorts. A previously identified metabolic fingerprint associated with atherosclerosis was also analyzed and its potential risk estimation investigated in the three aged cohorts. Three different metabolic signatures were identified according to age: 2-hydroxybutyrate, gamma-aminobutyric acid, hypoxanthine, guanidoacetate, oxaloacetate, and serine in young adults; citrate, cyclohexanol, glutamine, lysine, pantothenate, pipecolate, threonine, and tyramine shared by middle-aged and elderly adults; and trimethylamine N-oxide and glucuronate associated with cardiovascular risk in all three cohorts. The urinary metabolome contains a metabolic signature of cardiovascular risk that differs across age groups. These signatures might serve to complement existing algorithms and improve the accuracy of cardiovascular risk prediction for personalized prevention.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
2021
2021-01-11
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/9619
url http://hdl.handle.net/11268/9619
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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