The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway

In 1993, Brewster and Gustin described the existence of a kinase whose activity was essential for Saccharomyces cerevisiae to grow in environments with high osmolarity. This led to the discovery of the HOG pathway, a MAP kinase (MAPK) pathway that has been revealed to be crucial to respond to a wide...

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Detalhes bibliográficos
Autores: Román González, Elvira, Correia, Ines, Prieto Prieto, Antonio Daniel, Alonso Monge, Rebeca María Del Mar, Pla Alonso, Jesús
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/129415
Acesso em linha:https://hdl.handle.net/20.500.14352/129415
Access Level:acceso abierto
Palavra-chave:579
HOG
MAPK
Candida albicans
Stress
Fungi
Microbiología (Farmacia)
2414 Microbiología
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spelling The HOG MAPK pathway in Candida albicans: more than an osmosensing pathwayRomán González, ElviraCorreia, InesPrieto Prieto, Antonio DanielAlonso Monge, Rebeca María Del MarPla Alonso, Jesús579HOGMAPKCandida albicansStressFungiMicrobiología (Farmacia)2414 MicrobiologíaIn 1993, Brewster and Gustin described the existence of a kinase whose activity was essential for Saccharomyces cerevisiae to grow in environments with high osmolarity. This led to the discovery of the HOG pathway, a MAP kinase (MAPK) pathway that has been revealed to be crucial to respond to a wide range of stress conditions frequently encountered by fungi in their common habitats. MAPK signaling is initiated at the plasma membrane, where triggering stimuli lead to a phosphorylation cascade that ultimately activates transcription factors to ensure an appropriate adaptive response. In pathogenic fungi, the HOG pathway gains special significance as it is involved in traits related to pathogenicity; these include biofilm formation, adhesion to surfaces, and morphogenetic and epigenetic transitions. It also plays a role in controlling both the pathogen and the commensal state program. Understanding the signals leading to its activation, the elements of the pathways and the targets of the pathway are therefore of primary importance in the design of novel antifungals.Springer NatureUniversidad Complutense de Madrid20192019-01-0120192019-01-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcAMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/129415reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1294152026-06-02T12:44:21Z
dc.title.none.fl_str_mv The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
title The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
spellingShingle The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
Román González, Elvira
579
HOG
MAPK
Candida albicans
Stress
Fungi
Microbiología (Farmacia)
2414 Microbiología
title_short The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
title_full The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
title_fullStr The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
title_full_unstemmed The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
title_sort The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
dc.creator.none.fl_str_mv Román González, Elvira
Correia, Ines
Prieto Prieto, Antonio Daniel
Alonso Monge, Rebeca María Del Mar
Pla Alonso, Jesús
author Román González, Elvira
author_facet Román González, Elvira
Correia, Ines
Prieto Prieto, Antonio Daniel
Alonso Monge, Rebeca María Del Mar
Pla Alonso, Jesús
author_role author
author2 Correia, Ines
Prieto Prieto, Antonio Daniel
Alonso Monge, Rebeca María Del Mar
Pla Alonso, Jesús
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579
HOG
MAPK
Candida albicans
Stress
Fungi
Microbiología (Farmacia)
2414 Microbiología
topic 579
HOG
MAPK
Candida albicans
Stress
Fungi
Microbiología (Farmacia)
2414 Microbiología
description In 1993, Brewster and Gustin described the existence of a kinase whose activity was essential for Saccharomyces cerevisiae to grow in environments with high osmolarity. This led to the discovery of the HOG pathway, a MAP kinase (MAPK) pathway that has been revealed to be crucial to respond to a wide range of stress conditions frequently encountered by fungi in their common habitats. MAPK signaling is initiated at the plasma membrane, where triggering stimuli lead to a phosphorylation cascade that ultimately activates transcription factors to ensure an appropriate adaptive response. In pathogenic fungi, the HOG pathway gains special significance as it is involved in traits related to pathogenicity; these include biofilm formation, adhesion to surfaces, and morphogenetic and epigenetic transitions. It also plays a role in controlling both the pathogen and the commensal state program. Understanding the signals leading to its activation, the elements of the pathways and the targets of the pathway are therefore of primary importance in the design of novel antifungals.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/129415
url https://hdl.handle.net/20.500.14352/129415
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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