Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort

Diet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn's disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospecti...

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Autores: Guevara, Marcela, Salamanca Fernández, Elena, Miqueleiz, Estrella, Gavrila, Diana, Amiano, Pilar, Bonet Bonet, Catalina, Rodríguez Barranco, Miguel, Huerta, José María, Bujanda, Luis, Sánchez, María José, Chirlaque, María Dolores, Agudo, Antonio, Ardanaz, Eva, Castilla, Jesús
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/179797
Acceso en línea:https://hdl.handle.net/2445/179797
Access Level:acceso abierto
Palabra clave:Malaltia de Crohn
Dieta
Inflamació
Crohn's disease
Diet
Inflammation
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spelling Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain CohortGuevara, MarcelaSalamanca Fernández, ElenaMiqueleiz, EstrellaGavrila, DianaAmiano, PilarBonet Bonet, CatalinaRodríguez Barranco, MiguelHuerta, José MaríaBujanda, LuisSánchez, María JoséChirlaque, María DoloresAgudo, AntonioArdanaz, EvaCastilla, JesúsMalaltia de CrohnDietaInflamacióCrohn's diseaseDietInflammationDiet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn's disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The study included 32,633 participants aged 29-69 years. The inflammatory potential of the diet was measured by using an inflammatory score of the diet (ISD) based on a baseline dietary history questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 21 years (674,547 person-years) of follow-up, 32 and 57 participants developed CD and UC, respectively. In multivariable analysis, a one-standard deviation (SD) increment in the ISD (two-unit increase) was associated with a higher risk of CD (HR of 1.71; 95% CI: 1.05-2.80; p = 0.031). By contrast, ISD was not associated with UC (HR for one-SD increment of 0.89; 95% CI: 0.66-1.19; p = 0.436). Our results suggest that consuming a more pro-inflammatory diet may contribute to the risk of CD, supporting that a healthy diet might be beneficial in its prevention. Further, larger studies are needed to verify these findings.MDPI AG2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/179797Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu13072201Nutrients, 2021, vol. 13, num. 7, p. 2201https://doi.org/10.3390/nu13072201cc by (c) Guevara, Marcela et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1797972026-05-27T06:46:51Z
dc.title.none.fl_str_mv Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
title Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
spellingShingle Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
Guevara, Marcela
Malaltia de Crohn
Dieta
Inflamació
Crohn's disease
Diet
Inflammation
title_short Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
title_full Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
title_fullStr Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
title_full_unstemmed Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
title_sort Inflammatory Potential of the Diet and Incidence of Crohn’s Disease and Ulcerative Colitis in the EPIC-Spain Cohort
dc.creator.none.fl_str_mv Guevara, Marcela
Salamanca Fernández, Elena
Miqueleiz, Estrella
Gavrila, Diana
Amiano, Pilar
Bonet Bonet, Catalina
Rodríguez Barranco, Miguel
Huerta, José María
Bujanda, Luis
Sánchez, María José
Chirlaque, María Dolores
Agudo, Antonio
Ardanaz, Eva
Castilla, Jesús
author Guevara, Marcela
author_facet Guevara, Marcela
Salamanca Fernández, Elena
Miqueleiz, Estrella
Gavrila, Diana
Amiano, Pilar
Bonet Bonet, Catalina
Rodríguez Barranco, Miguel
Huerta, José María
Bujanda, Luis
Sánchez, María José
Chirlaque, María Dolores
Agudo, Antonio
Ardanaz, Eva
Castilla, Jesús
author_role author
author2 Salamanca Fernández, Elena
Miqueleiz, Estrella
Gavrila, Diana
Amiano, Pilar
Bonet Bonet, Catalina
Rodríguez Barranco, Miguel
Huerta, José María
Bujanda, Luis
Sánchez, María José
Chirlaque, María Dolores
Agudo, Antonio
Ardanaz, Eva
Castilla, Jesús
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Crohn
Dieta
Inflamació
Crohn's disease
Diet
Inflammation
topic Malaltia de Crohn
Dieta
Inflamació
Crohn's disease
Diet
Inflammation
description Diet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn's disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The study included 32,633 participants aged 29-69 years. The inflammatory potential of the diet was measured by using an inflammatory score of the diet (ISD) based on a baseline dietary history questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 21 years (674,547 person-years) of follow-up, 32 and 57 participants developed CD and UC, respectively. In multivariable analysis, a one-standard deviation (SD) increment in the ISD (two-unit increase) was associated with a higher risk of CD (HR of 1.71; 95% CI: 1.05-2.80; p = 0.031). By contrast, ISD was not associated with UC (HR for one-SD increment of 0.89; 95% CI: 0.66-1.19; p = 0.436). Our results suggest that consuming a more pro-inflammatory diet may contribute to the risk of CD, supporting that a healthy diet might be beneficial in its prevention. Further, larger studies are needed to verify these findings.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179797
url https://hdl.handle.net/2445/179797
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu13072201
Nutrients, 2021, vol. 13, num. 7, p. 2201
https://doi.org/10.3390/nu13072201
dc.rights.none.fl_str_mv cc by (c) Guevara, Marcela et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Guevara, Marcela et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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