Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota

Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety. Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensation...

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Autores: Barber Caselles, Claudia|||0000-0003-4711-2731, Sabater, Carlos|||0000-0002-6098-895X, Ávila-Gálvez, María Ángeles|||0000-0003-2513-1026, Vallejo, Fernando|||0000-0003-3343-6479, Bendezú García, Rogger Álvaro, Guérin-Deremaux, Laetitia, Guarner, Francisco|||0000-0002-4051-0836, Espín, Juan Carlos|||0000-0002-1068-8692, Margolles, Abelardo, Azpiroz Vidaur, Fernando|||0000-0002-7327-960X
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:268810
Acceso en línea:https://ddd.uab.cat/record/268810
https://dx.doi.org/urn:doi:10.3390/nu14214611
Access Level:acceso abierto
Palabra clave:Prebiotic
Gut microbiota
Metagenomics
Metabolomics
Digestive sensations
Intestinal gas
Resistant dextrin
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spelling Effect of Resistant Dextrin on Intestinal Gas Homeostasis and MicrobiotaBarber Caselles, Claudia|||0000-0003-4711-2731Sabater, Carlos|||0000-0002-6098-895XÁvila-Gálvez, María Ángeles|||0000-0003-2513-1026Vallejo, Fernando|||0000-0003-3343-6479Bendezú García, Rogger ÁlvaroGuérin-Deremaux, LaetitiaGuarner, Francisco|||0000-0002-4051-0836Espín, Juan Carlos|||0000-0002-1068-8692Margolles, AbelardoAzpiroz Vidaur, Fernando|||0000-0002-7327-960XPrebioticGut microbiotaMetagenomicsMetabolomicsDigestive sensationsIntestinal gasResistant dextrinPrevious studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety. Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition. Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE ®, Roquette Frères, Lestrem, France) for four weeks. Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine. Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation. Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism. These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/268810https://dx.doi.org/urn:doi:10.3390/nu14214611reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2021-122295OB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-103914RB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-78311-RMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FJC2019-042125-Iopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2688102026-06-06T12:50:31Z
dc.title.none.fl_str_mv Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
title Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
spellingShingle Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
Barber Caselles, Claudia|||0000-0003-4711-2731
Prebiotic
Gut microbiota
Metagenomics
Metabolomics
Digestive sensations
Intestinal gas
Resistant dextrin
title_short Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
title_full Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
title_fullStr Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
title_full_unstemmed Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
title_sort Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
dc.creator.none.fl_str_mv Barber Caselles, Claudia|||0000-0003-4711-2731
Sabater, Carlos|||0000-0002-6098-895X
Ávila-Gálvez, María Ángeles|||0000-0003-2513-1026
Vallejo, Fernando|||0000-0003-3343-6479
Bendezú García, Rogger Álvaro
Guérin-Deremaux, Laetitia
Guarner, Francisco|||0000-0002-4051-0836
Espín, Juan Carlos|||0000-0002-1068-8692
Margolles, Abelardo
Azpiroz Vidaur, Fernando|||0000-0002-7327-960X
author Barber Caselles, Claudia|||0000-0003-4711-2731
author_facet Barber Caselles, Claudia|||0000-0003-4711-2731
Sabater, Carlos|||0000-0002-6098-895X
Ávila-Gálvez, María Ángeles|||0000-0003-2513-1026
Vallejo, Fernando|||0000-0003-3343-6479
Bendezú García, Rogger Álvaro
Guérin-Deremaux, Laetitia
Guarner, Francisco|||0000-0002-4051-0836
Espín, Juan Carlos|||0000-0002-1068-8692
Margolles, Abelardo
Azpiroz Vidaur, Fernando|||0000-0002-7327-960X
author_role author
author2 Sabater, Carlos|||0000-0002-6098-895X
Ávila-Gálvez, María Ángeles|||0000-0003-2513-1026
Vallejo, Fernando|||0000-0003-3343-6479
Bendezú García, Rogger Álvaro
Guérin-Deremaux, Laetitia
Guarner, Francisco|||0000-0002-4051-0836
Espín, Juan Carlos|||0000-0002-1068-8692
Margolles, Abelardo
Azpiroz Vidaur, Fernando|||0000-0002-7327-960X
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Prebiotic
Gut microbiota
Metagenomics
Metabolomics
Digestive sensations
Intestinal gas
Resistant dextrin
topic Prebiotic
Gut microbiota
Metagenomics
Metabolomics
Digestive sensations
Intestinal gas
Resistant dextrin
description Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety. Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition. Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE ®, Roquette Frères, Lestrem, France) for four weeks. Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine. Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation. Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism. These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/268810
https://dx.doi.org/urn:doi:10.3390/nu14214611
url https://ddd.uab.cat/record/268810
https://dx.doi.org/urn:doi:10.3390/nu14214611
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2021-122295OB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-103914RB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-78311-R
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FJC2019-042125-I
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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