Breast cancer dormancy is associated with a 4NG1 state and not senescence

Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cells, highlighting the need for a deeper understanding and re...

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Autores: Prunier, Chloé, Alay, Ania, Dijk, Michiel van, Ammerlaan, Kelly L., Gelderen, Sharon van, Marvin, Dieuwke L., Teunisse, Amina, Slieker, Roderick C., Szuhai, Karoly, Jochemsen, A. G., Solé, Xavier, Dijke, Peter ten, Ritsma, Laila
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/181196
Acesso em linha:https://hdl.handle.net/2445/181196
Access Level:Acceso aberto
Palavra-chave:Càncer de mama
Cèl·lules canceroses
Breast cancer
Cancer cells
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spelling Breast cancer dormancy is associated with a 4NG1 state and not senescencePrunier, ChloéAlay, AniaDijk, Michiel vanAmmerlaan, Kelly L.Gelderen, Sharon vanMarvin, Dieuwke L.Teunisse, AminaSlieker, Roderick C.Szuhai, KarolyJochemsen, A. G.Solé, XavierDijke, Peter tenRitsma, LailaCàncer de mamaCèl·lules cancerosesBreast cancerCancer cellsReactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cells, highlighting the need for a deeper understanding and reliable models. Here, we thoroughly characterize the dormant D2.OR and ZR-75-1, and proliferative D2A1 breast cancer cell line models in vivo and/or in vitro, and assess if there is overlap between a dormant and a senescent phenotype. We show that D2.OR but not D2A1 cells become dormant in the liver of an immunocompetent model. In vitro, we show that D2.OR and ZR-75-1 cells in response to a 3D environment or serum-free conditions are growth-arrested in G1, of which a subpopulation resides in a 4NG1 state. The dormancy state is reversible and not associated with a senescence phenotype. This will aid future research on breast cancer dormancy.Springer Science and Business Media LLC2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/181196Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41523-021-00347-0npj Breast Cancer, 2021, vol. 7, num. 1https://doi.org/10.1038/s41523-021-00347-0cc by (c) Prunier, Chloé et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1811962026-05-29T05:05:01Z
dc.title.none.fl_str_mv Breast cancer dormancy is associated with a 4NG1 state and not senescence
title Breast cancer dormancy is associated with a 4NG1 state and not senescence
spellingShingle Breast cancer dormancy is associated with a 4NG1 state and not senescence
Prunier, Chloé
Càncer de mama
Cèl·lules canceroses
Breast cancer
Cancer cells
title_short Breast cancer dormancy is associated with a 4NG1 state and not senescence
title_full Breast cancer dormancy is associated with a 4NG1 state and not senescence
title_fullStr Breast cancer dormancy is associated with a 4NG1 state and not senescence
title_full_unstemmed Breast cancer dormancy is associated with a 4NG1 state and not senescence
title_sort Breast cancer dormancy is associated with a 4NG1 state and not senescence
dc.creator.none.fl_str_mv Prunier, Chloé
Alay, Ania
Dijk, Michiel van
Ammerlaan, Kelly L.
Gelderen, Sharon van
Marvin, Dieuwke L.
Teunisse, Amina
Slieker, Roderick C.
Szuhai, Karoly
Jochemsen, A. G.
Solé, Xavier
Dijke, Peter ten
Ritsma, Laila
author Prunier, Chloé
author_facet Prunier, Chloé
Alay, Ania
Dijk, Michiel van
Ammerlaan, Kelly L.
Gelderen, Sharon van
Marvin, Dieuwke L.
Teunisse, Amina
Slieker, Roderick C.
Szuhai, Karoly
Jochemsen, A. G.
Solé, Xavier
Dijke, Peter ten
Ritsma, Laila
author_role author
author2 Alay, Ania
Dijk, Michiel van
Ammerlaan, Kelly L.
Gelderen, Sharon van
Marvin, Dieuwke L.
Teunisse, Amina
Slieker, Roderick C.
Szuhai, Karoly
Jochemsen, A. G.
Solé, Xavier
Dijke, Peter ten
Ritsma, Laila
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de mama
Cèl·lules canceroses
Breast cancer
Cancer cells
topic Càncer de mama
Cèl·lules canceroses
Breast cancer
Cancer cells
description Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cells, highlighting the need for a deeper understanding and reliable models. Here, we thoroughly characterize the dormant D2.OR and ZR-75-1, and proliferative D2A1 breast cancer cell line models in vivo and/or in vitro, and assess if there is overlap between a dormant and a senescent phenotype. We show that D2.OR but not D2A1 cells become dormant in the liver of an immunocompetent model. In vitro, we show that D2.OR and ZR-75-1 cells in response to a 3D environment or serum-free conditions are growth-arrested in G1, of which a subpopulation resides in a 4NG1 state. The dormancy state is reversible and not associated with a senescence phenotype. This will aid future research on breast cancer dormancy.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181196
url https://hdl.handle.net/2445/181196
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41523-021-00347-0
npj Breast Cancer, 2021, vol. 7, num. 1
https://doi.org/10.1038/s41523-021-00347-0
dc.rights.none.fl_str_mv cc by (c) Prunier, Chloé et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Prunier, Chloé et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Science and Business Media LLC
publisher.none.fl_str_mv Springer Science and Business Media LLC
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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