A baseline metabolomic signature is associated with immunological CD4+ T-Cell recovery after 36 months of art in HIV-infected patients

Poor immunological recovery in treated HIV-infected patients is associated with greater morbidity and mortality. To date, predictive biomarkers of this incomplete immune reconstitution have not been established. We aimed to identify a baseline metabolomic signature associated with a poor immunologic...

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Detalles Bibliográficos
Autores: Rodríguez-Gallego, Esther, Gómez, Josep, Pacheco, Yolanda M., Peraire, Joaquim, Viladés, Consuelo, Beltrán-Debón, Raúl, Mallol, Roger, López-Dupla, Miguel, Veloso, Sergi, Alba, Verónica, Blanco, Julià, Rull, Anna, Cañellas, Nicolau, Leal, Manuel, Correig, Xavier, Domingo, Pere, Vidal, Francesc
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/182225
Acceso en línea:http://hdl.handle.net/10261/182225
Access Level:acceso abierto
Palabra clave:ART
Biomarkers
HIV-1
Metabolomics
Poor immune recovery
Descripción
Sumario:Poor immunological recovery in treated HIV-infected patients is associated with greater morbidity and mortality. To date, predictive biomarkers of this incomplete immune reconstitution have not been established. We aimed to identify a baseline metabolomic signature associated with a poor immunological recovery after ART in order to envisage the underlying mechanistic pathways that influence the treatment response.

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