Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome

Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden. Atherosclerosis and heart failure contribute sign...

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Detalhes bibliográficos
Autores: Hamczyk, Magda R., del Campo, Lara, Andres, Vicente
Tipo de documento: artigo
Data de publicação:2018
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositório:Repisalud
Idioma:inglês
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7966
Acesso em linha:http://hdl.handle.net/20.500.12105/7966
Access Level:Acceso aberto
Palavra-chave:Aging
Animals
Cardiovascular Diseases
Cardiovascular System
Humans
Progeria
Vascular Calcification
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spelling Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria SyndromeHamczyk, Magda R.del Campo, LaraAndres, VicenteAgingAnimalsCardiovascular DiseasesCardiovascular SystemHumansProgeriaVascular CalcificationAging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden. Atherosclerosis and heart failure contribute significantly to age-associated CVD-related morbimortality. CVD and aging are both accelerated in patients suffering from Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder caused by the prelamin A mutant progerin. Progerin causes extensive atherosclerosis and cardiac electrophysiological alterations that invariably lead to premature aging and death. This review summarizes the main structural and functional alterations to the cardiovascular system during physiological and premature aging and discusses the mechanisms underlying exaggerated CVD and aging induced by prelamin A and progerin. Because both proteins are expressed in normally aging non-HGPS individuals, and most hallmarks of normal aging occur in progeria, research on HGPS can identify mechanisms underlying physiological aging.Progeria Research FoundationInstituto de Salud Carlos IIIMinisterio de Economía, Industria y Competitividad (España)Fundación ProCNIC20192019-07-1920182018-02-0120182018-02-01journal articlehttp://purl.org/coar/resource_type/c_6501SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/7966reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES SEV-2015-0505 Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/79662026-06-12T12:43:37Z
dc.title.none.fl_str_mv Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
title Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
spellingShingle Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
Hamczyk, Magda R.
Aging
Animals
Cardiovascular Diseases
Cardiovascular System
Humans
Progeria
Vascular Calcification
title_short Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
title_full Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
title_fullStr Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
title_full_unstemmed Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
title_sort Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
dc.creator.none.fl_str_mv Hamczyk, Magda R.
del Campo, Lara
Andres, Vicente
author Hamczyk, Magda R.
author_facet Hamczyk, Magda R.
del Campo, Lara
Andres, Vicente
author_role author
author2 del Campo, Lara
Andres, Vicente
author2_role author
author
dc.contributor.none.fl_str_mv Progeria Research Foundation
Instituto de Salud Carlos III
Ministerio de Economía, Industria y Competitividad (España)
Fundación ProCNIC
dc.subject.none.fl_str_mv Aging
Animals
Cardiovascular Diseases
Cardiovascular System
Humans
Progeria
Vascular Calcification
topic Aging
Animals
Cardiovascular Diseases
Cardiovascular System
Humans
Progeria
Vascular Calcification
description Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden. Atherosclerosis and heart failure contribute significantly to age-associated CVD-related morbimortality. CVD and aging are both accelerated in patients suffering from Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder caused by the prelamin A mutant progerin. Progerin causes extensive atherosclerosis and cardiac electrophysiological alterations that invariably lead to premature aging and death. This review summarizes the main structural and functional alterations to the cardiovascular system during physiological and premature aging and discusses the mechanisms underlying exaggerated CVD and aging induced by prelamin A and progerin. Because both proteins are expressed in normally aging non-HGPS individuals, and most hallmarks of normal aging occur in progeria, research on HGPS can identify mechanisms underlying physiological aging.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-02-01
2018
2018-02-01
2019
2019-07-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
SMUR
http://purl.org/coar/version/c_71e4c1898caa6e32
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/7966
url http://hdl.handle.net/20.500.12105/7966
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES SEV-2015-0505 Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-CompartirIgual 4.0 Internacional
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-CompartirIgual 4.0 Internacional
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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