Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons

Background: Since influenza predisposes to bacterial pneumonia caused by Streptococcus pneumoniae, studies have suggested that pneumococcal vaccination might reduce its occurrence during pandemics. We assessed the effectiveness of pneumococcal polysaccharide vaccination alone and in combination with...

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Autores: Dominguez, A, Castilla, J, Godoy, P, Delgado-Rodriguez, M, Saez, M, Soldevila, N, Astray, J, Mayoral, JM, Martin, V, Quintana, JM, Gonzalez-Candelas, F, Galan, JC, Tamames, S, Castro, A, Baricot, M, Garin, O, Pumarola, T, CIBERESP Cases Controls Pandemic
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p12592
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/12592
Access Level:acceso abierto
Palavra-chave:effectiveness
hospitalization
influenza vaccine
laboratory-confirmed influenza
pneumococcal polysaccharide vaccine
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spelling Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasonsDominguez, ACastilla, JGodoy, PDelgado-Rodriguez, MSaez, MSoldevila, NAstray, JMayoral, JMMartin, VQuintana, JMGonzalez-Candelas, FGalan, JCTamames, SCastro, ABaricot, MGarin, OPumarola, TCIBERESP Cases Controls Pandemiceffectivenesshospitalizationinfluenza vaccinelaboratory-confirmed influenzapneumococcal polysaccharide vaccineBackground: Since influenza predisposes to bacterial pneumonia caused by Streptococcus pneumoniae, studies have suggested that pneumococcal vaccination might reduce its occurrence during pandemics. We assessed the effectiveness of pneumococcal polysaccharide vaccination alone and in combination with influenza vaccination in preventing influenza hospitalization during the 2009-2010 pandemic wave and 2010-2011 influenza epidemic. Methods: We conducted a multicenter case-control study in 36 Spanish hospitals. We selected patients aged 18 y hospitalized with confirmed influenza and two hospitalized controls per case, matched according to age, date of hospitalization and province of residence. Multivariate analysis was performed using conditional logistic regression. Subjects were considered vaccinated if they had received the pneumococcal or seasonal influenza vaccine > 14 d (or > 7 d for pandemic influenza vaccine) before the onset of symptoms (cases) or the onset of symptoms in matched cases (controls). Results: 1187 cases and 2328 controls were included. The adjusted estimate of effectiveness of pneumococcal vaccination in preventing influenza hospitalization was 41% (95% CI 8-62) in all patients and 43% (95% CI 2-78) in patients aged 65 y. The adjusted effectiveness of dual PPV23 and influenza vaccination was 81% (95% CI 65-90) in all patients and 76% (95% CI 46-90) in patients aged 65 y. The adjusted effectiveness of influenza vaccination alone was 58% (95% CI 38-72). Conclusions: In elderly people and adults with chronic illness, pneumococcal vaccination may reduce hospitalizations during the influenza season. In people vaccinated with both the influenza and pneumococcal vaccines, the benefit in hospitalizations avoided was greater than in those vaccinated only against influenza.TAYLOR & FRANCIS INC2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/12592Human Vaccines & ImmunotherapeuticsISSN: 21645515ISSNe: 2164554Xreponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p125922026-06-11T12:45:17Z
dc.title.none.fl_str_mv Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
title Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
spellingShingle Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
Dominguez, A
effectiveness
hospitalization
influenza vaccine
laboratory-confirmed influenza
pneumococcal polysaccharide vaccine
title_short Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
title_full Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
title_fullStr Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
title_full_unstemmed Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
title_sort Effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine in preventing hospitalization with laboratory confirmed influenza during the 2009-2010 and 2010-2011 seasons
dc.creator.none.fl_str_mv Dominguez, A
Castilla, J
Godoy, P
Delgado-Rodriguez, M
Saez, M
Soldevila, N
Astray, J
Mayoral, JM
Martin, V
Quintana, JM
Gonzalez-Candelas, F
Galan, JC
Tamames, S
Castro, A
Baricot, M
Garin, O
Pumarola, T
CIBERESP Cases Controls Pandemic
author Dominguez, A
author_facet Dominguez, A
Castilla, J
Godoy, P
Delgado-Rodriguez, M
Saez, M
Soldevila, N
Astray, J
Mayoral, JM
Martin, V
Quintana, JM
Gonzalez-Candelas, F
Galan, JC
Tamames, S
Castro, A
Baricot, M
Garin, O
Pumarola, T
CIBERESP Cases Controls Pandemic
author_role author
author2 Castilla, J
Godoy, P
Delgado-Rodriguez, M
Saez, M
Soldevila, N
Astray, J
Mayoral, JM
Martin, V
Quintana, JM
Gonzalez-Candelas, F
Galan, JC
Tamames, S
Castro, A
Baricot, M
Garin, O
Pumarola, T
CIBERESP Cases Controls Pandemic
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv effectiveness
hospitalization
influenza vaccine
laboratory-confirmed influenza
pneumococcal polysaccharide vaccine
topic effectiveness
hospitalization
influenza vaccine
laboratory-confirmed influenza
pneumococcal polysaccharide vaccine
description Background: Since influenza predisposes to bacterial pneumonia caused by Streptococcus pneumoniae, studies have suggested that pneumococcal vaccination might reduce its occurrence during pandemics. We assessed the effectiveness of pneumococcal polysaccharide vaccination alone and in combination with influenza vaccination in preventing influenza hospitalization during the 2009-2010 pandemic wave and 2010-2011 influenza epidemic. Methods: We conducted a multicenter case-control study in 36 Spanish hospitals. We selected patients aged 18 y hospitalized with confirmed influenza and two hospitalized controls per case, matched according to age, date of hospitalization and province of residence. Multivariate analysis was performed using conditional logistic regression. Subjects were considered vaccinated if they had received the pneumococcal or seasonal influenza vaccine > 14 d (or > 7 d for pandemic influenza vaccine) before the onset of symptoms (cases) or the onset of symptoms in matched cases (controls). Results: 1187 cases and 2328 controls were included. The adjusted estimate of effectiveness of pneumococcal vaccination in preventing influenza hospitalization was 41% (95% CI 8-62) in all patients and 43% (95% CI 2-78) in patients aged 65 y. The adjusted effectiveness of dual PPV23 and influenza vaccination was 81% (95% CI 65-90) in all patients and 76% (95% CI 46-90) in patients aged 65 y. The adjusted effectiveness of influenza vaccination alone was 58% (95% CI 38-72). Conclusions: In elderly people and adults with chronic illness, pneumococcal vaccination may reduce hospitalizations during the influenza season. In people vaccinated with both the influenza and pneumococcal vaccines, the benefit in hospitalizations avoided was greater than in those vaccinated only against influenza.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/12592
url https://fisabio.portalinvestigacion.com/publicaciones/12592
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv TAYLOR & FRANCIS INC
publisher.none.fl_str_mv TAYLOR & FRANCIS INC
dc.source.none.fl_str_mv Human Vaccines & Immunotherapeutics
ISSN: 21645515
ISSNe: 2164554X
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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