Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity

Nowadays, with the increase of elderly population and related health problems, knee and hip joint prosthesis are being widely used worldwide. However, failure of these invasive devices occurs in a high percentage thus demanding the revision of the chirurgical procedure. Within the reasons of failure...

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Detalles Bibliográficos
Autores: Ferreri, I., Calderon, V.S., Escobar-Galindo, Ramón, Palacio, Carlos, Henriques, M., Piedade, A.P., Carvalho, S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/147166
Acceso en línea:https://hdl.handle.net/11441/147166
https://doi.org/10.1016/j.msec.2015.05.071
Access Level:acceso abierto
Palabra clave:Sputtering
Biomaterial
Bacterial adhesion
Silver activation
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spelling Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activityFerreri, I.Calderon, V.S.Escobar-Galindo, RamónPalacio, CarlosHenriques, M.Piedade, A.P.Carvalho, S.SputteringBiomaterialBacterial adhesionSilver activationNowadays, with the increase of elderly population and related health problems, knee and hip joint prosthesis are being widely used worldwide. However, failure of these invasive devices occurs in a high percentage thus demanding the revision of the chirurgical procedure. Within the reasons of failure, microbial infections, either hospital or subsequently-acquired, contribute in high number to the statistics. Staphylococcus epidermidis (S. epidermidis) has emerged as one of the major nosocomial pathogens associated with these infections. Silver has a historic performance in medicine due to its potent antimicrobial activity, with a broad-spectrum on the activity of different types of microorganisms. Consequently, the main goal of this work was to produce Ag–ZrCN coatings with antimicrobial activity, for the surface modification of hip prostheses. Thin films of ZrCN with several silver concentrations were deposited onto stainless steel 316 L, by DC reactive magnetron sputtering, using two targets, Zr and Zr with silver pellets (Zr + Ag target), in an atmosphere containing Ar, C2H2 and N2. The antimicrobial activity of the modified surfaces was tested against S. epidermidis and the influence of an activation step of silver was assessed by testing samples after immersion in a 5% (w/v) NaClO solution for 5 min. The activation procedure revealed to be essential for the antimicrobial activity, as observed by the presence of an inhibition halo on the surface with 11 at.% of Ag. The morphology analysis of the surface before and after the activation procedure revealed differences in silver distribution indicating segregation/diffusion of the metallic element to the film's surface. Thus, the results indicate that the silver activation step is responsible for an antimicrobial effect of the coatings, due to silver oxidation and silver ion release.ScienceDirectFísica Aplicada I2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/147166https://doi.org/10.1016/j.msec.2015.05.071reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésMaterials Science and Engineering: C, 55, 547-555.https://www.sciencedirect.com/science/article/pii/S0928493115301235?via%3Dihubinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1471662026-06-17T12:51:07Z
dc.title.none.fl_str_mv Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity
title Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity
spellingShingle Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity
Ferreri, I.
Sputtering
Biomaterial
Bacterial adhesion
Silver activation
title_short Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity
title_full Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity
title_fullStr Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity
title_full_unstemmed Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity
title_sort Silver activation on thin films of Ag–ZrCN coatings for antimicrobial activity
dc.creator.none.fl_str_mv Ferreri, I.
Calderon, V.S.
Escobar-Galindo, Ramón
Palacio, Carlos
Henriques, M.
Piedade, A.P.
Carvalho, S.
author Ferreri, I.
author_facet Ferreri, I.
Calderon, V.S.
Escobar-Galindo, Ramón
Palacio, Carlos
Henriques, M.
Piedade, A.P.
Carvalho, S.
author_role author
author2 Calderon, V.S.
Escobar-Galindo, Ramón
Palacio, Carlos
Henriques, M.
Piedade, A.P.
Carvalho, S.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Física Aplicada I
dc.subject.none.fl_str_mv Sputtering
Biomaterial
Bacterial adhesion
Silver activation
topic Sputtering
Biomaterial
Bacterial adhesion
Silver activation
description Nowadays, with the increase of elderly population and related health problems, knee and hip joint prosthesis are being widely used worldwide. However, failure of these invasive devices occurs in a high percentage thus demanding the revision of the chirurgical procedure. Within the reasons of failure, microbial infections, either hospital or subsequently-acquired, contribute in high number to the statistics. Staphylococcus epidermidis (S. epidermidis) has emerged as one of the major nosocomial pathogens associated with these infections. Silver has a historic performance in medicine due to its potent antimicrobial activity, with a broad-spectrum on the activity of different types of microorganisms. Consequently, the main goal of this work was to produce Ag–ZrCN coatings with antimicrobial activity, for the surface modification of hip prostheses. Thin films of ZrCN with several silver concentrations were deposited onto stainless steel 316 L, by DC reactive magnetron sputtering, using two targets, Zr and Zr with silver pellets (Zr + Ag target), in an atmosphere containing Ar, C2H2 and N2. The antimicrobial activity of the modified surfaces was tested against S. epidermidis and the influence of an activation step of silver was assessed by testing samples after immersion in a 5% (w/v) NaClO solution for 5 min. The activation procedure revealed to be essential for the antimicrobial activity, as observed by the presence of an inhibition halo on the surface with 11 at.% of Ag. The morphology analysis of the surface before and after the activation procedure revealed differences in silver distribution indicating segregation/diffusion of the metallic element to the film's surface. Thus, the results indicate that the silver activation step is responsible for an antimicrobial effect of the coatings, due to silver oxidation and silver ion release.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/147166
https://doi.org/10.1016/j.msec.2015.05.071
url https://hdl.handle.net/11441/147166
https://doi.org/10.1016/j.msec.2015.05.071
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Materials Science and Engineering: C, 55, 547-555.
https://www.sciencedirect.com/science/article/pii/S0928493115301235?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ScienceDirect
publisher.none.fl_str_mv ScienceDirect
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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