Influence of early neurological complications on clinical outcome following lung transplant

BACKGROUND. Neurological complications after lung transplantation are common. The full spectrum of neurological complications and their impact on clinical outcomes has not been extensively studied. METHODS. We investigated the neurological incidence of complications, categorized according to whether...

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Autores: Gamez, Josep, Salvado, Maria, Martinez de La Ossa, Alejandro, Romero, Laura, Román, Antonio, Sacanell, Judith, Laborda, César, Rochera, Isabel, Nadal, Miriam, Carmona Pontaque, Francesc, Santamarina, Estevo, Raguer, Nuria, Canela, Merce, Solé, Joan, Deu, Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/120448
Acceso en línea:https://hdl.handle.net/2445/120448
Access Level:acceso abierto
Palabra clave:Trasplantament d'òrgans
Pulmó
Sistema nerviós central
Transplantation of organs
Lung
Central nervous system
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spelling Influence of early neurological complications on clinical outcome following lung transplantGamez, JosepSalvado, MariaMartinez de La Ossa, AlejandroRomero, LauraRomán, AntonioSacanell, JudithLaborda, CésarRochera, IsabelNadal, MiriamCarmona Pontaque, FrancescSantamarina, EstevoRaguer, NuriaCanela, MerceSolé, JoanDeu, MariaTrasplantament d'òrgansPulmóSistema nerviós centralTransplantation of organsLungCentral nervous systemBACKGROUND. Neurological complications after lung transplantation are common. The full spectrum of neurological complications and their impact on clinical outcomes has not been extensively studied. METHODS. We investigated the neurological incidence of complications, categorized according to whether they affected the central, peripheral or autonomic nervous systems, in a series of 109 patients undergoing lung transplantation at our center between January 1 2013 and December 31 2014. RESULTS. Fifty-one patients (46.8%) presented at least one neurological complication. Critical illness polyneuropathy-myopathy (31 cases) and phrenic nerve injury (26 cases) were the two most prevalent complications. These two neuromuscular complications lengthened hospital stays by a median period of 35.5 and 32.5 days respectively. However, neurological complications did not affect patients' survival. CONCLUSIONS. The real incidence of neurological complications among lung transplant recipients is probably underestimated. They usually appear in the first two months after surgery. Despite not affecting mortality, they do affect the mean length of hospital stay, and especially the time spent in the Intensive Care Unit. We found no risk factor for neurological complications except for long operating times, ischemic time and need for transfusion. It is necessary to develop programs for the prevention and early recognition of these complications, and the prevention of their precipitant and risk factors.Public Library of Science (PLoS)2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/120448Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0174092PLoS One, 2017, vol. 12, num. 3, p. e0174092https://doi.org/10.1371/journal.pone.0174092cc-by (c) Gamez, Josep et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1204482026-05-29T05:05:01Z
dc.title.none.fl_str_mv Influence of early neurological complications on clinical outcome following lung transplant
title Influence of early neurological complications on clinical outcome following lung transplant
spellingShingle Influence of early neurological complications on clinical outcome following lung transplant
Gamez, Josep
Trasplantament d'òrgans
Pulmó
Sistema nerviós central
Transplantation of organs
Lung
Central nervous system
title_short Influence of early neurological complications on clinical outcome following lung transplant
title_full Influence of early neurological complications on clinical outcome following lung transplant
title_fullStr Influence of early neurological complications on clinical outcome following lung transplant
title_full_unstemmed Influence of early neurological complications on clinical outcome following lung transplant
title_sort Influence of early neurological complications on clinical outcome following lung transplant
dc.creator.none.fl_str_mv Gamez, Josep
Salvado, Maria
Martinez de La Ossa, Alejandro
Romero, Laura
Román, Antonio
Sacanell, Judith
Laborda, César
Rochera, Isabel
Nadal, Miriam
Carmona Pontaque, Francesc
Santamarina, Estevo
Raguer, Nuria
Canela, Merce
Solé, Joan
Deu, Maria
author Gamez, Josep
author_facet Gamez, Josep
Salvado, Maria
Martinez de La Ossa, Alejandro
Romero, Laura
Román, Antonio
Sacanell, Judith
Laborda, César
Rochera, Isabel
Nadal, Miriam
Carmona Pontaque, Francesc
Santamarina, Estevo
Raguer, Nuria
Canela, Merce
Solé, Joan
Deu, Maria
author_role author
author2 Salvado, Maria
Martinez de La Ossa, Alejandro
Romero, Laura
Román, Antonio
Sacanell, Judith
Laborda, César
Rochera, Isabel
Nadal, Miriam
Carmona Pontaque, Francesc
Santamarina, Estevo
Raguer, Nuria
Canela, Merce
Solé, Joan
Deu, Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trasplantament d'òrgans
Pulmó
Sistema nerviós central
Transplantation of organs
Lung
Central nervous system
topic Trasplantament d'òrgans
Pulmó
Sistema nerviós central
Transplantation of organs
Lung
Central nervous system
description BACKGROUND. Neurological complications after lung transplantation are common. The full spectrum of neurological complications and their impact on clinical outcomes has not been extensively studied. METHODS. We investigated the neurological incidence of complications, categorized according to whether they affected the central, peripheral or autonomic nervous systems, in a series of 109 patients undergoing lung transplantation at our center between January 1 2013 and December 31 2014. RESULTS. Fifty-one patients (46.8%) presented at least one neurological complication. Critical illness polyneuropathy-myopathy (31 cases) and phrenic nerve injury (26 cases) were the two most prevalent complications. These two neuromuscular complications lengthened hospital stays by a median period of 35.5 and 32.5 days respectively. However, neurological complications did not affect patients' survival. CONCLUSIONS. The real incidence of neurological complications among lung transplant recipients is probably underestimated. They usually appear in the first two months after surgery. Despite not affecting mortality, they do affect the mean length of hospital stay, and especially the time spent in the Intensive Care Unit. We found no risk factor for neurological complications except for long operating times, ischemic time and need for transfusion. It is necessary to develop programs for the prevention and early recognition of these complications, and the prevention of their precipitant and risk factors.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120448
url https://hdl.handle.net/2445/120448
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0174092
PLoS One, 2017, vol. 12, num. 3, p. e0174092
https://doi.org/10.1371/journal.pone.0174092
dc.rights.none.fl_str_mv cc-by (c) Gamez, Josep et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Gamez, Josep et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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