Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers

Anonymous data of two clinical trials. Twenty-six healthy participants were randomized to T20/90mg vs. placebo (n = 12) or RAL/400mg vs. placebo (n = 14) every 12h in two 7-day periods separated by a 4-week washout period. Major end-points were changes in lipid profile (total cholesterol, high-densi...

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Detalles Bibliográficos
Autores: Garrabou Tornos, Glòria, Martínez, Esteban
Tipo de recurso: conjunto de datos
Fecha de publicación:2021
País:España
Institución:Consorci de Serveis Universitaris de Catalunya (CSUC)
Repositorio:CORA.Repositori de Dades de Recerca
OAI Identifier:oai:dnet:cora.rdr____::11f342d3de28a2b1ec1df5e0e11c6c1e
Acceso en línea:https://doi.org/10.34810/DATA83
Access Level:acceso abierto
Palabra clave:Medicine, Health and Life Sciences
antiretroviral
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spelling Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteersGarrabou Tornos, GlòriaMartínez, EstebanMedicine, Health and Life SciencesantiretroviralAnonymous data of two clinical trials. Twenty-six healthy participants were randomized to T20/90mg vs. placebo (n = 12) or RAL/400mg vs. placebo (n = 14) every 12h in two 7-day periods separated by a 4-week washout period. Major end-points were changes in lipid profile (total cholesterol, high-density-lipoprotein (HDL)-cholesterol, low-density-lipoprotein (LDL)-cholesterol, triglycerides), insulin resistance (glucose) and mitochondrial toxicity (mitochondrial DNA content–mtDNA–in peripheral blood mononuclear cells). Renal and hepatic toxicity (creatinine, alanine transaminase (AST), alanine aminotransferase (ALT), bilirubin and total plasma proteins) and overall safety were also analysed. Effect of period, treatment, and basal measures were evaluated for each end-point.CORA.Repositori de Dades de Recerca2021info:eu-repo/semantics/datasethttps://doi.org/10.34810/DATA83reponame:CORA.Repositori de Dades de Recercainstname:Consorci de Serveis Universitaris de Catalunya (CSUC)Inglésinfo:eu-repo/semantics/openAccessCustom Dataset Termsoai:dnet:cora.rdr____::11f342d3de28a2b1ec1df5e0e11c6c1e2026-06-17T12:20:17Z
dc.title.none.fl_str_mv Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers
title Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers
spellingShingle Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers
Garrabou Tornos, Glòria
Medicine, Health and Life Sciences
antiretroviral
title_short Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers
title_full Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers
title_fullStr Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers
title_full_unstemmed Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers
title_sort Supplemental Data of: Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: randomized crossover clinical trial in healthy volunteers
dc.creator.none.fl_str_mv Garrabou Tornos, Glòria
Martínez, Esteban
author Garrabou Tornos, Glòria
author_facet Garrabou Tornos, Glòria
Martínez, Esteban
author_role author
author2 Martínez, Esteban
author2_role author
dc.subject.none.fl_str_mv Medicine, Health and Life Sciences
antiretroviral
topic Medicine, Health and Life Sciences
antiretroviral
description Anonymous data of two clinical trials. Twenty-six healthy participants were randomized to T20/90mg vs. placebo (n = 12) or RAL/400mg vs. placebo (n = 14) every 12h in two 7-day periods separated by a 4-week washout period. Major end-points were changes in lipid profile (total cholesterol, high-density-lipoprotein (HDL)-cholesterol, low-density-lipoprotein (LDL)-cholesterol, triglycerides), insulin resistance (glucose) and mitochondrial toxicity (mitochondrial DNA content–mtDNA–in peripheral blood mononuclear cells). Renal and hepatic toxicity (creatinine, alanine transaminase (AST), alanine aminotransferase (ALT), bilirubin and total plasma proteins) and overall safety were also analysed. Effect of period, treatment, and basal measures were evaluated for each end-point.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
format dataset
dc.identifier.none.fl_str_mv https://doi.org/10.34810/DATA83
url https://doi.org/10.34810/DATA83
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Custom Dataset Terms
eu_rights_str_mv openAccess
rights_invalid_str_mv Custom Dataset Terms
dc.publisher.none.fl_str_mv CORA.Repositori de Dades de Recerca
publisher.none.fl_str_mv CORA.Repositori de Dades de Recerca
dc.source.none.fl_str_mv reponame:CORA.Repositori de Dades de Recerca
instname:Consorci de Serveis Universitaris de Catalunya (CSUC)
instname_str Consorci de Serveis Universitaris de Catalunya (CSUC)
reponame_str CORA.Repositori de Dades de Recerca
collection CORA.Repositori de Dades de Recerca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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