Autophagy and autophagic cell death in sepsis

In sepsis, inflammation, and nutrient deficiencies endanger cellular homeostasis and survival. Autophagy is primarily a mechanism of cellular survival under fasting conditions. However, autophagy-dependent cell death, known as autophagic cell death, is proinflammatory and can exacerbate sepsis. Auto...

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Authors: Iba, Toshiaki|||0000-0002-0255-4088, Helms, Julie|||0000-0003-0895-6800, Maier, Cheryl L.|||0000-0003-4044-2674, Ferrer, Ricard|||0000-0002-4859-4747, Levy, Jerrold H.|||0000-0003-3766-4962
Format: article
Publication Date:2024
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:322322
Online Access:https://ddd.uab.cat/record/322322
https://dx.doi.org/urn:doi:10.1186/s40560-024-00754-y
Access Level:Open access
Keyword:Autophagy
Sepsis
Mitochondria
Apoptosis
Necrosis
Mitophagy
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repository_id_str
spelling Autophagy and autophagic cell death in sepsisfriend or foe?Iba, Toshiaki|||0000-0002-0255-4088Helms, Julie|||0000-0003-0895-6800Maier, Cheryl L.|||0000-0003-4044-2674Ferrer, Ricard|||0000-0002-4859-4747Levy, Jerrold H.|||0000-0003-3766-4962AutophagySepsisMitochondriaApoptosisNecrosisMitophagyIn sepsis, inflammation, and nutrient deficiencies endanger cellular homeostasis and survival. Autophagy is primarily a mechanism of cellular survival under fasting conditions. However, autophagy-dependent cell death, known as autophagic cell death, is proinflammatory and can exacerbate sepsis. Autophagy also regulates various types of non-inflammatory and inflammatory cell deaths. Non-inflammatory apoptosis tends to suppress inflammation, however, inflammatory necroptosis, pyroptosis, ferroptosis, and autophagic cell death lead to the release of inflammatory cytokines and damage-associated molecular patterns (DAMPs) and amplify inflammation. The selection of cell death mechanisms is complex and often involves a mixture of various styles. Similarly, protective autophagy and lethal autophagy may be triggered simultaneously in cells. How cells balance the regulatory mechanisms of these processes is an area of interest that is still under investigation. Therapies aimed at modulating autophagy are considered promising. Enhancing autophagy helps clear and recycle damaged organelles and reduce the burden of inflammatory processes while inhibiting excessive autophagy, which could prevent autophagic cell death. In this review, we introduce recent advances in research and the complex regulatory system of autophagy in sepsis. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/322322https://dx.doi.org/urn:doi:10.1186/s40560-024-00754-yreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3223222026-06-06T12:50:31Z
dc.title.none.fl_str_mv Autophagy and autophagic cell death in sepsis
friend or foe?
title Autophagy and autophagic cell death in sepsis
spellingShingle Autophagy and autophagic cell death in sepsis
Iba, Toshiaki|||0000-0002-0255-4088
Autophagy
Sepsis
Mitochondria
Apoptosis
Necrosis
Mitophagy
title_short Autophagy and autophagic cell death in sepsis
title_full Autophagy and autophagic cell death in sepsis
title_fullStr Autophagy and autophagic cell death in sepsis
title_full_unstemmed Autophagy and autophagic cell death in sepsis
title_sort Autophagy and autophagic cell death in sepsis
dc.creator.none.fl_str_mv Iba, Toshiaki|||0000-0002-0255-4088
Helms, Julie|||0000-0003-0895-6800
Maier, Cheryl L.|||0000-0003-4044-2674
Ferrer, Ricard|||0000-0002-4859-4747
Levy, Jerrold H.|||0000-0003-3766-4962
author Iba, Toshiaki|||0000-0002-0255-4088
author_facet Iba, Toshiaki|||0000-0002-0255-4088
Helms, Julie|||0000-0003-0895-6800
Maier, Cheryl L.|||0000-0003-4044-2674
Ferrer, Ricard|||0000-0002-4859-4747
Levy, Jerrold H.|||0000-0003-3766-4962
author_role author
author2 Helms, Julie|||0000-0003-0895-6800
Maier, Cheryl L.|||0000-0003-4044-2674
Ferrer, Ricard|||0000-0002-4859-4747
Levy, Jerrold H.|||0000-0003-3766-4962
author2_role author
author
author
author
dc.subject.none.fl_str_mv Autophagy
Sepsis
Mitochondria
Apoptosis
Necrosis
Mitophagy
topic Autophagy
Sepsis
Mitochondria
Apoptosis
Necrosis
Mitophagy
description In sepsis, inflammation, and nutrient deficiencies endanger cellular homeostasis and survival. Autophagy is primarily a mechanism of cellular survival under fasting conditions. However, autophagy-dependent cell death, known as autophagic cell death, is proinflammatory and can exacerbate sepsis. Autophagy also regulates various types of non-inflammatory and inflammatory cell deaths. Non-inflammatory apoptosis tends to suppress inflammation, however, inflammatory necroptosis, pyroptosis, ferroptosis, and autophagic cell death lead to the release of inflammatory cytokines and damage-associated molecular patterns (DAMPs) and amplify inflammation. The selection of cell death mechanisms is complex and often involves a mixture of various styles. Similarly, protective autophagy and lethal autophagy may be triggered simultaneously in cells. How cells balance the regulatory mechanisms of these processes is an area of interest that is still under investigation. Therapies aimed at modulating autophagy are considered promising. Enhancing autophagy helps clear and recycle damaged organelles and reduce the burden of inflammatory processes while inhibiting excessive autophagy, which could prevent autophagic cell death. In this review, we introduce recent advances in research and the complex regulatory system of autophagy in sepsis.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/322322
https://dx.doi.org/urn:doi:10.1186/s40560-024-00754-y
url https://ddd.uab.cat/record/322322
https://dx.doi.org/urn:doi:10.1186/s40560-024-00754-y
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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