Plasma proteomics uncovers divergent molecular signatures in ischemic stroke and intracerebral hemorrhage

[Background] Timely differentiation between ischemic stroke (IS) and intracerebral hemorrhage (ICH) is critical for guiding appropriate acute management strategies. While neuroimaging is the diagnostic gold standard, its accessibility is often limited in urgent clinical settings. Blood biomarkers of...

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Detalles Bibliográficos
Autores: Núñez Jurado, David, Fernández-Vega, Alejandro, Del Río, Carmen, Penalba, Anna, Llucià-Carol, Laia, Muiño-Acuña, Elena, Ezcurra-Díaz, Garbiñe, Guasch-Jiménez, Marina, Cullell, Natalia, Serrano-Heras, Gemma, Arias-Salazar, Lourdes, Vives-Bauza, Cristòfol, Tur, Silvia, Urra, Xabier, Castellanos, Mar, Krupinski, Jerzy, Freijo-Guerrero, Marimar, Jiménez-Conde, Jordi, Fernández-Pérez, Isabel, Segura, Tomás, Marti-Fabregas, Joan, Férnandez-Cadenas, Israel, Montaner, Joan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/412632
Acceso en línea:http://hdl.handle.net/10261/412632
https://api.elsevier.com/content/abstract/scopus_id/105020273967
Access Level:acceso abierto
Palabra clave:Biomarkers
Neuroinflammation
Proteomics
Stroke
Descripción
Sumario:[Background] Timely differentiation between ischemic stroke (IS) and intracerebral hemorrhage (ICH) is critical for guiding appropriate acute management strategies. While neuroimaging is the diagnostic gold standard, its accessibility is often limited in urgent clinical settings. Blood biomarkers offer a promising, scalable diagnostic alternative; however, no validated panel is yet available for distinguishing stroke subtypes during the hyperacute phase.

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