Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism

Introduction Anticoagulant therapy is critical for venous thromboembolism (VTE) management, though bleeding remains a major concern, ranging from mild to fatal events. This study aimed to assess the predictive value of cytokines for major bleeding in patients with acute pulmonary embolism (PE). Meth...

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Authors: Oblitas, Crhistian Mario, Lago Rodríguez, Marta‐Olimpia, López Rubio, Marina, García Gámiz, Mercedes, Zamora Trillo, Angielys, Álvarez-Sala Walther, Luis Antonio, Galeano Valle, Francisco, Demelo Rodríguez, Pablo
Format: article
Publication Date:2025
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/133005
Online Access:https://hdl.handle.net/20.500.14352/133005
Access Level:Open access
Keyword:616-005.7
Bleeding
Cytokines
Interleukins
Mayor bleeding
Prognostic
Pulmonary embolism
Venous thromboembolism
Medicina
Medicina interna
3205 Medicina Interna
id ES_d01c40bcf1189ed048be44bcc1e98ff2
oai_identifier_str oai:docta.ucm.es:20.500.14352/133005
network_acronym_str ES
network_name_str España
repository_id_str
spelling Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary EmbolismOblitas, Crhistian MarioLago Rodríguez, Marta‐OlimpiaLópez Rubio, MarinaGarcía Gámiz, MercedesZamora Trillo, AngielysÁlvarez-Sala Walther, Luis AntonioGaleano Valle, FranciscoDemelo Rodríguez, Pablo616-005.7BleedingCytokinesInterleukinsMayor bleedingPrognosticPulmonary embolismVenous thromboembolismMedicinaMedicina interna3205 Medicina InternaIntroduction Anticoagulant therapy is critical for venous thromboembolism (VTE) management, though bleeding remains a major concern, ranging from mild to fatal events. This study aimed to assess the predictive value of cytokines for major bleeding in patients with acute pulmonary embolism (PE). Methods In this prospective, observational study, patients aged ≥ 18 years with acute PE were enrolled from April 2021 to September 2022 and followed for 30 days. Exclusion criteria included asymptomatic PE, VTE without PE, and chronic anticoagulation. Major bleeding was defined as bleeding that required ≥ 2 transfused units of red blood cells, occurred in critical areas, or was fatal. Blood samples were collected at diagnosis to measure IL‐6, IL‐1beta, IL‐8, IL‐10, and TNF‐alpha. Statistical analyses used bivariate and multivariate logistic regression (p < 0.05). Results Out of 191 patients (mean age 68.6 years, 52.9% male), 8.4% died, and 4.2% experienced major bleeding within 30 days. IL‐8 > 40 pg/mL and TNF‐alpha > 8.5 pg/mL were linked to major bleeding. IL‐8 > 40 pg/mL independently predicted early major bleeding (adjusted OR 9.40; 95% CI 1.38–63.69). Cox regression showed HRs of 12.60 for IL‐8 and 5.61 for TNF‐alpha. Conclusion High IL‐8 levels at diagnosis were predictive of major bleeding in acute PE patients. Further studies are required to confirm these findings.WileyUniversidad Complutense de Madrid20252025-01-1820252025-01-18journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/133005reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1330052026-06-02T12:44:21Z
dc.title.none.fl_str_mv Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
title Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
spellingShingle Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
Oblitas, Crhistian Mario
616-005.7
Bleeding
Cytokines
Interleukins
Mayor bleeding
Prognostic
Pulmonary embolism
Venous thromboembolism
Medicina
Medicina interna
3205 Medicina Interna
title_short Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
title_full Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
title_fullStr Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
title_full_unstemmed Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
title_sort Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
dc.creator.none.fl_str_mv Oblitas, Crhistian Mario
Lago Rodríguez, Marta‐Olimpia
López Rubio, Marina
García Gámiz, Mercedes
Zamora Trillo, Angielys
Álvarez-Sala Walther, Luis Antonio
Galeano Valle, Francisco
Demelo Rodríguez, Pablo
author Oblitas, Crhistian Mario
author_facet Oblitas, Crhistian Mario
Lago Rodríguez, Marta‐Olimpia
López Rubio, Marina
García Gámiz, Mercedes
Zamora Trillo, Angielys
Álvarez-Sala Walther, Luis Antonio
Galeano Valle, Francisco
Demelo Rodríguez, Pablo
author_role author
author2 Lago Rodríguez, Marta‐Olimpia
López Rubio, Marina
García Gámiz, Mercedes
Zamora Trillo, Angielys
Álvarez-Sala Walther, Luis Antonio
Galeano Valle, Francisco
Demelo Rodríguez, Pablo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-005.7
Bleeding
Cytokines
Interleukins
Mayor bleeding
Prognostic
Pulmonary embolism
Venous thromboembolism
Medicina
Medicina interna
3205 Medicina Interna
topic 616-005.7
Bleeding
Cytokines
Interleukins
Mayor bleeding
Prognostic
Pulmonary embolism
Venous thromboembolism
Medicina
Medicina interna
3205 Medicina Interna
description Introduction Anticoagulant therapy is critical for venous thromboembolism (VTE) management, though bleeding remains a major concern, ranging from mild to fatal events. This study aimed to assess the predictive value of cytokines for major bleeding in patients with acute pulmonary embolism (PE). Methods In this prospective, observational study, patients aged ≥ 18 years with acute PE were enrolled from April 2021 to September 2022 and followed for 30 days. Exclusion criteria included asymptomatic PE, VTE without PE, and chronic anticoagulation. Major bleeding was defined as bleeding that required ≥ 2 transfused units of red blood cells, occurred in critical areas, or was fatal. Blood samples were collected at diagnosis to measure IL‐6, IL‐1beta, IL‐8, IL‐10, and TNF‐alpha. Statistical analyses used bivariate and multivariate logistic regression (p < 0.05). Results Out of 191 patients (mean age 68.6 years, 52.9% male), 8.4% died, and 4.2% experienced major bleeding within 30 days. IL‐8 > 40 pg/mL and TNF‐alpha > 8.5 pg/mL were linked to major bleeding. IL‐8 > 40 pg/mL independently predicted early major bleeding (adjusted OR 9.40; 95% CI 1.38–63.69). Cox regression showed HRs of 12.60 for IL‐8 and 5.61 for TNF‐alpha. Conclusion High IL‐8 levels at diagnosis were predictive of major bleeding in acute PE patients. Further studies are required to confirm these findings.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-18
2025
2025-01-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/133005
url https://hdl.handle.net/20.500.14352/133005
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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