Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy

Nanoparticles (NPs) are very small particles with distinct properties stemming from their nanometric size and large surface area, setting them apart from bulk materials. NPs provide many benefits, such as high drug loading capacity, specific targeting, prolonged circulation, and minimized side effec...

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Detalhes bibliográficos
Autores: Bangay, Gabrielle, Isca, Vera, Morais, João, Fernandez Alarcon, Jennifer, S. Viana, Ana, Reis, Catarina, Pereira Leite, Catarina, Ana M., Díaz Lanza, Saraiva, Lucília, Fornaguera, Cristina, Rijo, Patrícia Dias de Mendonça
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/5675
Acesso em linha:http://hdl.handle.net/20.500.14342/5675
https://doi.org/10.1016/j.jddst.2025.107389
Access Level:acceso abierto
Palavra-chave:Gold nanoparticles
Plectranthus grandidentatus
Diterpene
Cytotoxic
Breast cancer
Nanopartícules
Or
Diterpens
Citotoxicitat
Mama--Càncer
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spelling Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapyBangay, GabrielleIsca, VeraMorais, JoãoFernandez Alarcon, JenniferS. Viana, AnaReis, CatarinaPereira Leite, CatarinaAna M., Díaz LanzaSaraiva, LucíliaFornaguera, CristinaRijo, Patrícia Dias de MendonçaGold nanoparticlesPlectranthus grandidentatusDiterpeneCytotoxicBreast cancerNanopartículesOrDiterpensCitotoxicitatMama--CàncerNanoparticles (NPs) are very small particles with distinct properties stemming from their nanometric size and large surface area, setting them apart from bulk materials. NPs provide many benefits, such as high drug loading capacity, specific targeting, prolonged circulation, and minimized side effects. Over the past few years, metal-based NPs, such as gold NPs (AuNPs), have gained special attention due their surface plasmon resonance properties and use in drug and gene delivery, particularly in cancer treatment and theragnostics. Abietane diterpenoids, such as 7α-acetoxy-6β-hydroxyroyleanone (Roy) isolated from Plectranthus spp., are known to be cytotoxic agents, ideal for chemotherapeutic applications. Yet, their poor water solubility and low bioavailability limit their therapeutic efficacy. Harnessing the effectiveness of AuNPs, several nanosystems were made using Roy, the natural diterpene, and an ester derivative. After characterization of size, PDI, zeta potential and encapsulation efficiency, antitumour analysis using in vitro cancer cell models of breast cancer (MDA-MB-231, 4T1 and MCF7) were used to probe cytotoxic effect. Roy-functionalised AuNPs showed increased antitumour activity when compared with Roy alone, showcasing the improved antitumoral effect of the nanoformulation. In addition, the Roy-functionalised AuNPs showed selectivity for cancer cells over healthy human fibroblast (HDF) cells, a promising incentive for further development of natural diterpenoid nanosystems in cancer therapy.info:eu-repo/semantics/publishedVersionElsevierUniversitat Ramon Llull. IQS2025info:eu-repo/semantics/articlep.8http://hdl.handle.net/20.500.14342/5675https://doi.org/10.1016/j.jddst.2025.107389reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Drug Delivery Science and Technology 2025, 114 (Part A)info:eu-repo/grantAgreement/SUR del DEC/SGR/2021 SGR 00537info:eu-repo/grantAgreement/MCI/PN I+D/PID2021-125910OB-I00© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/56752026-05-29T05:05:01Z
dc.title.none.fl_str_mv Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
title Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
spellingShingle Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
Bangay, Gabrielle
Gold nanoparticles
Plectranthus grandidentatus
Diterpene
Cytotoxic
Breast cancer
Nanopartícules
Or
Diterpens
Citotoxicitat
Mama--Càncer
title_short Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
title_full Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
title_fullStr Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
title_full_unstemmed Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
title_sort Functionalised gold nanoparticles using abietane diterpenoids from Plectranthus grandidentatus Gürke for cancer therapy
dc.creator.none.fl_str_mv Bangay, Gabrielle
Isca, Vera
Morais, João
Fernandez Alarcon, Jennifer
S. Viana, Ana
Reis, Catarina
Pereira Leite, Catarina
Ana M., Díaz Lanza
Saraiva, Lucília
Fornaguera, Cristina
Rijo, Patrícia Dias de Mendonça
author Bangay, Gabrielle
author_facet Bangay, Gabrielle
Isca, Vera
Morais, João
Fernandez Alarcon, Jennifer
S. Viana, Ana
Reis, Catarina
Pereira Leite, Catarina
Ana M., Díaz Lanza
Saraiva, Lucília
Fornaguera, Cristina
Rijo, Patrícia Dias de Mendonça
author_role author
author2 Isca, Vera
Morais, João
Fernandez Alarcon, Jennifer
S. Viana, Ana
Reis, Catarina
Pereira Leite, Catarina
Ana M., Díaz Lanza
Saraiva, Lucília
Fornaguera, Cristina
Rijo, Patrícia Dias de Mendonça
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Gold nanoparticles
Plectranthus grandidentatus
Diterpene
Cytotoxic
Breast cancer
Nanopartícules
Or
Diterpens
Citotoxicitat
Mama--Càncer
topic Gold nanoparticles
Plectranthus grandidentatus
Diterpene
Cytotoxic
Breast cancer
Nanopartícules
Or
Diterpens
Citotoxicitat
Mama--Càncer
description Nanoparticles (NPs) are very small particles with distinct properties stemming from their nanometric size and large surface area, setting them apart from bulk materials. NPs provide many benefits, such as high drug loading capacity, specific targeting, prolonged circulation, and minimized side effects. Over the past few years, metal-based NPs, such as gold NPs (AuNPs), have gained special attention due their surface plasmon resonance properties and use in drug and gene delivery, particularly in cancer treatment and theragnostics. Abietane diterpenoids, such as 7α-acetoxy-6β-hydroxyroyleanone (Roy) isolated from Plectranthus spp., are known to be cytotoxic agents, ideal for chemotherapeutic applications. Yet, their poor water solubility and low bioavailability limit their therapeutic efficacy. Harnessing the effectiveness of AuNPs, several nanosystems were made using Roy, the natural diterpene, and an ester derivative. After characterization of size, PDI, zeta potential and encapsulation efficiency, antitumour analysis using in vitro cancer cell models of breast cancer (MDA-MB-231, 4T1 and MCF7) were used to probe cytotoxic effect. Roy-functionalised AuNPs showed increased antitumour activity when compared with Roy alone, showcasing the improved antitumoral effect of the nanoformulation. In addition, the Roy-functionalised AuNPs showed selectivity for cancer cells over healthy human fibroblast (HDF) cells, a promising incentive for further development of natural diterpenoid nanosystems in cancer therapy.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/5675
https://doi.org/10.1016/j.jddst.2025.107389
url http://hdl.handle.net/20.500.14342/5675
https://doi.org/10.1016/j.jddst.2025.107389
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Drug Delivery Science and Technology 2025, 114 (Part A)
info:eu-repo/grantAgreement/SUR del DEC/SGR/2021 SGR 00537
info:eu-repo/grantAgreement/MCI/PN I+D/PID2021-125910OB-I00
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv p.8
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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