(1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors

Moderate wine consumption is associated with health-promoting activities. An H-NMR-based metabolomic approach was used to identify urinary metabolomic differences of moderate wine intake in the setting of a prospective, randomized, crossover, and controlled trial. Sixty-one male volunteers with high...

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Authors: Vázquez Fresno, Rosa, Llorach, Rafael, Alcaro, Francesca, Rodríguez Martínez, Miguel Ángel, Vinaixa Crevillent, Maria, Chiva Blanch, Gemma, Estruch Riba, Ramon, Correig Blanchar, Xavier, Andrés Lacueva, Ma. Cristina
Format: article
Status:Versión aceptada para publicación
Publication Date:2012
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/66118
Online Access:https://hdl.handle.net/2445/66118
Access Level:Open access
Keyword:Vi
Consum d'alcohol
Metabolisme
Malalties cardiovasculars
Ressonància magnètica nuclear
Marcadors bioquímics
Metabòlits
Wine
Drinking of alcoholic beverages
Metabolism
Cardiovascular diseases
Nuclear magnetic resonance
Biochemical markers
Metabolites
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oai_identifier_str oai:diposit.ub.edu:2445/66118
network_acronym_str ES
network_name_str España
repository_id_str
spelling (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factorsVázquez Fresno, RosaLlorach, RafaelAlcaro, FrancescaRodríguez Martínez, Miguel ÁngelVinaixa Crevillent, MariaChiva Blanch, GemmaEstruch Riba, RamonCorreig Blanchar, XavierAndrés Lacueva, Ma. CristinaViConsum d'alcoholMetabolismeMalalties cardiovascularsRessonància magnètica nuclearMarcadors bioquímicsMetabòlitsWineDrinking of alcoholic beveragesMetabolismCardiovascular diseasesNuclear magnetic resonanceBiochemical markersMetabolitesModerate wine consumption is associated with health-promoting activities. An H-NMR-based metabolomic approach was used to identify urinary metabolomic differences of moderate wine intake in the setting of a prospective, randomized, crossover, and controlled trial. Sixty-one male volunteers with high cardiovascular risk factors followed three dietary interventions (28 days): dealcoholized red wine (RWD) (272mL/day, polyphenol control), alcoholized red wine (RWA) (272mL/day) and gin (GIN) (100mL/day, alcohol control). After each period, 24-h urine samples were collected and analyzed by (1) H-NMR. According to the results of a one-way ANOVA, significant markers were grouped in four categories: alcohol-related markers (ethanol); gin-related markers; wine-related markers; and gut microbiota markers (hippurate and 4-hydroxphenylacetic acid). Wine metabolites were classified into two groups; first, metabolites of food metabolome: tartrate (RWA and RWD), ethanol, and mannitol (RWA); and second, biomarkers that relates to endogenous modifications after wine consumption, comprising branched-chain amino acid (BCAA) metabolite (3-methyl-oxovalerate). Additionally, a possible interaction between alcohol and gut-related biomarkers has been identified. To our knowledge, this is the first time that this approach has been applied in a nutritional intervention with red wine. The results show the capacity of this approach to obtain a comprehensive metabolome picture including food metabolome and endogenous biomarkers of moderate wine intake.Wiley-VCH2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/66118Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.1002/elps.201100646Electrophoresis, 2012, vol. 33, num. 15, p. 2345-2354http://dx.doi.org/10.1002/elps.201100646(c) Wiley-VCH, 2012info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/661182026-05-27T06:46:51Z
dc.title.none.fl_str_mv (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
title (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
spellingShingle (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
Vázquez Fresno, Rosa
Vi
Consum d'alcohol
Metabolisme
Malalties cardiovasculars
Ressonància magnètica nuclear
Marcadors bioquímics
Metabòlits
Wine
Drinking of alcoholic beverages
Metabolism
Cardiovascular diseases
Nuclear magnetic resonance
Biochemical markers
Metabolites
title_short (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
title_full (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
title_fullStr (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
title_full_unstemmed (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
title_sort (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors
dc.creator.none.fl_str_mv Vázquez Fresno, Rosa
Llorach, Rafael
Alcaro, Francesca
Rodríguez Martínez, Miguel Ángel
Vinaixa Crevillent, Maria
Chiva Blanch, Gemma
Estruch Riba, Ramon
Correig Blanchar, Xavier
Andrés Lacueva, Ma. Cristina
author Vázquez Fresno, Rosa
author_facet Vázquez Fresno, Rosa
Llorach, Rafael
Alcaro, Francesca
Rodríguez Martínez, Miguel Ángel
Vinaixa Crevillent, Maria
Chiva Blanch, Gemma
Estruch Riba, Ramon
Correig Blanchar, Xavier
Andrés Lacueva, Ma. Cristina
author_role author
author2 Llorach, Rafael
Alcaro, Francesca
Rodríguez Martínez, Miguel Ángel
Vinaixa Crevillent, Maria
Chiva Blanch, Gemma
Estruch Riba, Ramon
Correig Blanchar, Xavier
Andrés Lacueva, Ma. Cristina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Vi
Consum d'alcohol
Metabolisme
Malalties cardiovasculars
Ressonància magnètica nuclear
Marcadors bioquímics
Metabòlits
Wine
Drinking of alcoholic beverages
Metabolism
Cardiovascular diseases
Nuclear magnetic resonance
Biochemical markers
Metabolites
topic Vi
Consum d'alcohol
Metabolisme
Malalties cardiovasculars
Ressonància magnètica nuclear
Marcadors bioquímics
Metabòlits
Wine
Drinking of alcoholic beverages
Metabolism
Cardiovascular diseases
Nuclear magnetic resonance
Biochemical markers
Metabolites
description Moderate wine consumption is associated with health-promoting activities. An H-NMR-based metabolomic approach was used to identify urinary metabolomic differences of moderate wine intake in the setting of a prospective, randomized, crossover, and controlled trial. Sixty-one male volunteers with high cardiovascular risk factors followed three dietary interventions (28 days): dealcoholized red wine (RWD) (272mL/day, polyphenol control), alcoholized red wine (RWA) (272mL/day) and gin (GIN) (100mL/day, alcohol control). After each period, 24-h urine samples were collected and analyzed by (1) H-NMR. According to the results of a one-way ANOVA, significant markers were grouped in four categories: alcohol-related markers (ethanol); gin-related markers; wine-related markers; and gut microbiota markers (hippurate and 4-hydroxphenylacetic acid). Wine metabolites were classified into two groups; first, metabolites of food metabolome: tartrate (RWA and RWD), ethanol, and mannitol (RWA); and second, biomarkers that relates to endogenous modifications after wine consumption, comprising branched-chain amino acid (BCAA) metabolite (3-methyl-oxovalerate). Additionally, a possible interaction between alcohol and gut-related biomarkers has been identified. To our knowledge, this is the first time that this approach has been applied in a nutritional intervention with red wine. The results show the capacity of this approach to obtain a comprehensive metabolome picture including food metabolome and endogenous biomarkers of moderate wine intake.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/66118
url https://hdl.handle.net/2445/66118
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1002/elps.201100646
Electrophoresis, 2012, vol. 33, num. 15, p. 2345-2354
http://dx.doi.org/10.1002/elps.201100646
dc.rights.none.fl_str_mv (c) Wiley-VCH, 2012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley-VCH, 2012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420141577502720
score 15,301603

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