Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments

There is a growing concern about the risk of antibiotic resistance emergence and dissemination in the environment. Here, we evaluated the spatio-seasonal patterns of the impact of wastewater treatment plant (WWTP) effluents on antibiotic resistance in river sediments. To this purpose, sediment sampl...

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Autores: Beltrán de Heredia López, Irene, Garbisu Crespo, Carlos, Alcorta Calvo, Miren Itziar, Urra Ibañez de Sendadiano, Julen, González Gaya, Belén, Ruiz Romera, María Estilita
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/68076
Acceso en línea:http://hdl.handle.net/10810/68076
Access Level:acceso abierto
Palabra clave:antibiotic resistant genes
emerging contaminants
metals
mobile genetic elements
water quality
wastewater
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spelling Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sedimentsBeltrán de Heredia López, IreneGarbisu Crespo, CarlosAlcorta Calvo, Miren ItziarUrra Ibañez de Sendadiano, JulenGonzález Gaya, BelénRuiz Romera, María Estilitaantibiotic resistant genesemerging contaminantsmetalsmobile genetic elementswater qualitywastewaterThere is a growing concern about the risk of antibiotic resistance emergence and dissemination in the environment. Here, we evaluated the spatio-seasonal patterns of the impact of wastewater treatment plant (WWTP) effluents on antibiotic resistance in river sediments. To this purpose, sediment samples were collected in three river basins affected by WWTP effluents in wet (high-water period) and dry (low-water period) hydrological conditions at three locations: (i) upstream the WWTPs; (ii) WWTP effluent discharge points (effluent outfall); and (iii) downstream the WWTPs (500 m downriver from the effluent outfall). The absolute and relative abundances of 9 antibiotic resistance genes (ARGs), 3 mobile genetic element (MGE) genes, and 4 metal resistance genes (MRGs) were quantified in sediment samples, as well as a variety of physicochemical parameters, metal contents, and antibiotic concentrations in both sediment and water samples. In sediments, significantly higher relative abundances of most genes were observed in downstream vs. upstream sampling points. Seasonal changes (higher values in low-water vs. high-water period) were observed for both ARG absolute and relative abundances in sediment samples. Chemical data revealed the contribution of effluents from WWTPs as a source of antibiotic and metal contamination in river ecosystems. The observed positive correlations between ARG and MGE genes relative abundances point out to the role of horizontal gene transfer in antibiotic resistance dissemination. Monitoring plans that take into consideration spatio-temporal patterns must be implemented to properly assess the environmental fate of WWTP-related emerging contaminants in river ecosystems.Elsevier202420242023info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/68076reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.sciencedirect.com/science/article/pii/S026974912202098Xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/3.0/es/© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/)Atribución-NoComercial-SinDerivadas 3.0 Españaoai:addi.ehu.eus:10810/680762026-06-18T09:23:17Z
dc.title.none.fl_str_mv Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments
title Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments
spellingShingle Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments
Beltrán de Heredia López, Irene
antibiotic resistant genes
emerging contaminants
metals
mobile genetic elements
water quality
wastewater
title_short Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments
title_full Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments
title_fullStr Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments
title_full_unstemmed Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments
title_sort Spatio-seasonal patterns of the impact of wastewater treatment plant effluents on antibiotic resistance in river sediments
dc.creator.none.fl_str_mv Beltrán de Heredia López, Irene
Garbisu Crespo, Carlos
Alcorta Calvo, Miren Itziar
Urra Ibañez de Sendadiano, Julen
González Gaya, Belén
Ruiz Romera, María Estilita
author Beltrán de Heredia López, Irene
author_facet Beltrán de Heredia López, Irene
Garbisu Crespo, Carlos
Alcorta Calvo, Miren Itziar
Urra Ibañez de Sendadiano, Julen
González Gaya, Belén
Ruiz Romera, María Estilita
author_role author
author2 Garbisu Crespo, Carlos
Alcorta Calvo, Miren Itziar
Urra Ibañez de Sendadiano, Julen
González Gaya, Belén
Ruiz Romera, María Estilita
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv antibiotic resistant genes
emerging contaminants
metals
mobile genetic elements
water quality
wastewater
topic antibiotic resistant genes
emerging contaminants
metals
mobile genetic elements
water quality
wastewater
description There is a growing concern about the risk of antibiotic resistance emergence and dissemination in the environment. Here, we evaluated the spatio-seasonal patterns of the impact of wastewater treatment plant (WWTP) effluents on antibiotic resistance in river sediments. To this purpose, sediment samples were collected in three river basins affected by WWTP effluents in wet (high-water period) and dry (low-water period) hydrological conditions at three locations: (i) upstream the WWTPs; (ii) WWTP effluent discharge points (effluent outfall); and (iii) downstream the WWTPs (500 m downriver from the effluent outfall). The absolute and relative abundances of 9 antibiotic resistance genes (ARGs), 3 mobile genetic element (MGE) genes, and 4 metal resistance genes (MRGs) were quantified in sediment samples, as well as a variety of physicochemical parameters, metal contents, and antibiotic concentrations in both sediment and water samples. In sediments, significantly higher relative abundances of most genes were observed in downstream vs. upstream sampling points. Seasonal changes (higher values in low-water vs. high-water period) were observed for both ARG absolute and relative abundances in sediment samples. Chemical data revealed the contribution of effluents from WWTPs as a source of antibiotic and metal contamination in river ecosystems. The observed positive correlations between ARG and MGE genes relative abundances point out to the role of horizontal gene transfer in antibiotic resistance dissemination. Monitoring plans that take into consideration spatio-temporal patterns must be implemented to properly assess the environmental fate of WWTP-related emerging contaminants in river ecosystems.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/68076
url http://hdl.handle.net/10810/68076
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S026974912202098X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Atribución-NoComercial-SinDerivadas 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Atribución-NoComercial-SinDerivadas 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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