Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much

B-cell acute lymphoblastic leukemia (B-ALL) is characterized by an uncontrolled proliferation of blood cells in the bone marrow. A small fraction of B-ALL patients shows abnormally low chromosome numbers, defined as hypodiploidy, in leukemic cells. Hypodiploidy with less than 40 chromosomes is a rar...

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Autores: Molina, Òscar, Bataller Torralba, Alex, Thampi, Namitha, Ribera, Jordi, Granada, Isabel, Velasco, Pablo, Fuster, José Luis, Menéndez, Pablo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/218499
Acceso en línea:https://hdl.handle.net/2445/218499
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Leucèmia
Malalts de càncer
Biochemical markers
Leukemia
Cancer patients
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spelling Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too muchMolina, ÒscarBataller Torralba, AlexThampi, NamithaRibera, JordiGranada, IsabelVelasco, PabloFuster, José LuisMenéndez, PabloMarcadors bioquímicsLeucèmiaMalalts de càncerBiochemical markersLeukemiaCancer patientsB-cell acute lymphoblastic leukemia (B-ALL) is characterized by an uncontrolled proliferation of blood cells in the bone marrow. A small fraction of B-ALL patients shows abnormally low chromosome numbers, defined as hypodiploidy, in leukemic cells. Hypodiploidy with less than 40 chromosomes is a rare genetic abnormality in B-ALL and is associated to an extremely poor outcome, with low survival rates both in pediatric and adult cases. In this review, we describe the main clinical and genetic features of hypodiploid B-ALL subtypes with less than 40 chromosomes, the current treatment protocols and their clinical outcomes. Additionally, we discuss the potential cellular mechanisms involved on the origin of hypodiploidy, as well as its leukemogenic impact. Studies aiming to decipher the biological mechanisms involved in hypodiploid subtypes of B-ALL with less than 40 chromosomes are crucial to improve the poor survival rates in these patients.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/218499Articles publicats en revistes (Ciències Fisiològiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cancers14010032Cancers, 2021, vol. 14, num.1https://doi.org/10.3390/cancers14010032cc-by (c) Molina, O et al., 2021http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2184992026-05-27T06:46:51Z
dc.title.none.fl_str_mv Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much
title Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much
spellingShingle Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much
Molina, Òscar
Marcadors bioquímics
Leucèmia
Malalts de càncer
Biochemical markers
Leukemia
Cancer patients
title_short Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much
title_full Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much
title_fullStr Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much
title_full_unstemmed Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much
title_sort Near-haploidy and low-hypodiploidy in B-cell acute lymphoblastic leukemia: When less is too much
dc.creator.none.fl_str_mv Molina, Òscar
Bataller Torralba, Alex
Thampi, Namitha
Ribera, Jordi
Granada, Isabel
Velasco, Pablo
Fuster, José Luis
Menéndez, Pablo
author Molina, Òscar
author_facet Molina, Òscar
Bataller Torralba, Alex
Thampi, Namitha
Ribera, Jordi
Granada, Isabel
Velasco, Pablo
Fuster, José Luis
Menéndez, Pablo
author_role author
author2 Bataller Torralba, Alex
Thampi, Namitha
Ribera, Jordi
Granada, Isabel
Velasco, Pablo
Fuster, José Luis
Menéndez, Pablo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Leucèmia
Malalts de càncer
Biochemical markers
Leukemia
Cancer patients
topic Marcadors bioquímics
Leucèmia
Malalts de càncer
Biochemical markers
Leukemia
Cancer patients
description B-cell acute lymphoblastic leukemia (B-ALL) is characterized by an uncontrolled proliferation of blood cells in the bone marrow. A small fraction of B-ALL patients shows abnormally low chromosome numbers, defined as hypodiploidy, in leukemic cells. Hypodiploidy with less than 40 chromosomes is a rare genetic abnormality in B-ALL and is associated to an extremely poor outcome, with low survival rates both in pediatric and adult cases. In this review, we describe the main clinical and genetic features of hypodiploid B-ALL subtypes with less than 40 chromosomes, the current treatment protocols and their clinical outcomes. Additionally, we discuss the potential cellular mechanisms involved on the origin of hypodiploidy, as well as its leukemogenic impact. Studies aiming to decipher the biological mechanisms involved in hypodiploid subtypes of B-ALL with less than 40 chromosomes are crucial to improve the poor survival rates in these patients.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/218499
url https://hdl.handle.net/2445/218499
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers14010032
Cancers, 2021, vol. 14, num.1
https://doi.org/10.3390/cancers14010032
dc.rights.none.fl_str_mv cc-by (c) Molina, O et al., 2021
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Molina, O et al., 2021
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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