Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine

Dexmedetomidine and acepromazine, sedatives commonly used in dogs have opposite vascular effects, resulting in afterload increase and decrease, respectively. This could variably affect systolic myocardial function. Previous echocardiographic studies assessing the cardiovascular effects of these drug...

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Detalhes bibliográficos
Autores: Fernández Parra, Rocío, Tissier, Renaud, Alvarado, M. Paz, Sanjuan, Garde, Verwaerde, Patrick, Saponaro, V.
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/3386
Acesso em linha:http://hdl.handle.net/20.500.12466/3386
Access Level:acceso abierto
Palavra-chave:Afterload
Dog
Sedation
Speckle tracking echocardiography
Systolic function
3205.01 Cardiología
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oai_identifier_str oai:riucv.ucv.es:20.500.12466/3386
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spelling Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazineFernández Parra, RocíoTissier, RenaudAlvarado, M. PazSanjuan, GardeVerwaerde, PatrickSaponaro, V.AfterloadDogSedationSpeckle tracking echocardiographySystolic function3205.01 CardiologíaDexmedetomidine and acepromazine, sedatives commonly used in dogs have opposite vascular effects, resulting in afterload increase and decrease, respectively. This could variably affect systolic myocardial function. Previous echocardiographic studies assessing the cardiovascular effects of these drugs used conventional echocardiography, while advanced techniques such as speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI), which are known to provide a more accurate assessment of systolic function, have been rarely used for this aim. Moreover, in the few studies using advanced techniques, the drugs where combined with opioids. Therefore, the main objective of this prospective study was to assess systolic myocardial function by conventional and advanced echocardiography (STE and TDI), in dogs sedated exclusively with dexmedetomidine or acepromazine not combined with other drugs. Twenty healthy dogs were randomly divided into two groups, Group A (acepromazine, 20 μg/kg IM), and Group D (dexmedetomidine, 5 μg/kg IM), cardiovascular parameters were assessed before sedation (T0), and thirty minutes afterwards (T1). Systolic arterial pressure and heart rate decreased in both groups at T1 as compared to T0. Only one conventional echocardiographic raw variable (left ventricular internal dimension in systole) and three out of five advanced echocardiographic variables (radial TDI systolic velocities at the epicardial region of the left ventricular free wall, longitudinal TDI systolic velocities of the septal mitral valve annulus and the STE-derived left ventricular global strain), were affected in Group D. A systolic impairment was observed in Group D and better estimated by advanced echocardiography. In Group A, only the end diastolic voume index (conventional echocardiography) was decreased. Both protocols seem to induce echocardiographic changes more likely secondary to their vascular action.20232023-12-2220212021-12-0120212021-12-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12466/3386reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/33862026-06-19T08:32:07Z
dc.title.none.fl_str_mv Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine
title Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine
spellingShingle Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine
Fernández Parra, Rocío
Afterload
Dog
Sedation
Speckle tracking echocardiography
Systolic function
3205.01 Cardiología
title_short Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine
title_full Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine
title_fullStr Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine
title_full_unstemmed Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine
title_sort Conventional and advanced echocardiographic assessment of systolic function in dogs sedated with dexmedetomidine or acepromazine
dc.creator.none.fl_str_mv Fernández Parra, Rocío
Tissier, Renaud
Alvarado, M. Paz
Sanjuan, Garde
Verwaerde, Patrick
Saponaro, V.
author Fernández Parra, Rocío
author_facet Fernández Parra, Rocío
Tissier, Renaud
Alvarado, M. Paz
Sanjuan, Garde
Verwaerde, Patrick
Saponaro, V.
author_role author
author2 Tissier, Renaud
Alvarado, M. Paz
Sanjuan, Garde
Verwaerde, Patrick
Saponaro, V.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Afterload
Dog
Sedation
Speckle tracking echocardiography
Systolic function
3205.01 Cardiología
topic Afterload
Dog
Sedation
Speckle tracking echocardiography
Systolic function
3205.01 Cardiología
description Dexmedetomidine and acepromazine, sedatives commonly used in dogs have opposite vascular effects, resulting in afterload increase and decrease, respectively. This could variably affect systolic myocardial function. Previous echocardiographic studies assessing the cardiovascular effects of these drugs used conventional echocardiography, while advanced techniques such as speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI), which are known to provide a more accurate assessment of systolic function, have been rarely used for this aim. Moreover, in the few studies using advanced techniques, the drugs where combined with opioids. Therefore, the main objective of this prospective study was to assess systolic myocardial function by conventional and advanced echocardiography (STE and TDI), in dogs sedated exclusively with dexmedetomidine or acepromazine not combined with other drugs. Twenty healthy dogs were randomly divided into two groups, Group A (acepromazine, 20 μg/kg IM), and Group D (dexmedetomidine, 5 μg/kg IM), cardiovascular parameters were assessed before sedation (T0), and thirty minutes afterwards (T1). Systolic arterial pressure and heart rate decreased in both groups at T1 as compared to T0. Only one conventional echocardiographic raw variable (left ventricular internal dimension in systole) and three out of five advanced echocardiographic variables (radial TDI systolic velocities at the epicardial region of the left ventricular free wall, longitudinal TDI systolic velocities of the septal mitral valve annulus and the STE-derived left ventricular global strain), were affected in Group D. A systolic impairment was observed in Group D and better estimated by advanced echocardiography. In Group A, only the end diastolic voume index (conventional echocardiography) was decreased. Both protocols seem to induce echocardiographic changes more likely secondary to their vascular action.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-12-01
2021
2021-12-01
2023
2023-12-22
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12466/3386
url http://hdl.handle.net/20.500.12466/3386
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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