Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers

Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish I...

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Detalles Bibliográficos
Autores: Fossati, Serena, Valvi, Damaskini, 1983-, Martínez, David, Cirach, Marta, Estarlich, Marisa, Fernández-Somoano, Ana, Guxens Junyent, Mònica, Iñiguez, Carmen, Irizar, Amaia, Lertxundi, Aitana, Nieuwenhuijsen, Mark J., Tamayo-Uria, Ibon, Vioque, Jesus, Tardón, Adonina, Sunyer Deu, Jordi, Vrijheid, Martine
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/44235
Acceso en línea:http://hdl.handle.net/10230/44235
http://dx.doi.org/10.1016/j.envint.2020.105619
Access Level:acceso abierto
Palabra clave:Air pollution
Prenatal exposure
Childhood growth
Childhood obesity
Particulate matter
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dc.title.none.fl_str_mv Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
spellingShingle Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
Fossati, Serena
Air pollution
Prenatal exposure
Childhood growth
Childhood obesity
Particulate matter
title_short Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title_full Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title_fullStr Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title_full_unstemmed Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title_sort Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
dc.creator.none.fl_str_mv Fossati, Serena
Valvi, Damaskini, 1983-
Martínez, David
Cirach, Marta
Estarlich, Marisa
Fernández-Somoano, Ana
Guxens Junyent, Mònica
Iñiguez, Carmen
Irizar, Amaia
Lertxundi, Aitana
Nieuwenhuijsen, Mark J.
Tamayo-Uria, Ibon
Vioque, Jesus
Tardón, Adonina
Sunyer Deu, Jordi
Vrijheid, Martine
author Fossati, Serena
author_facet Fossati, Serena
Valvi, Damaskini, 1983-
Martínez, David
Cirach, Marta
Estarlich, Marisa
Fernández-Somoano, Ana
Guxens Junyent, Mònica
Iñiguez, Carmen
Irizar, Amaia
Lertxundi, Aitana
Nieuwenhuijsen, Mark J.
Tamayo-Uria, Ibon
Vioque, Jesus
Tardón, Adonina
Sunyer Deu, Jordi
Vrijheid, Martine
author_role author
author2 Valvi, Damaskini, 1983-
Martínez, David
Cirach, Marta
Estarlich, Marisa
Fernández-Somoano, Ana
Guxens Junyent, Mònica
Iñiguez, Carmen
Irizar, Amaia
Lertxundi, Aitana
Nieuwenhuijsen, Mark J.
Tamayo-Uria, Ibon
Vioque, Jesus
Tardón, Adonina
Sunyer Deu, Jordi
Vrijheid, Martine
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Air pollution
Prenatal exposure
Childhood growth
Childhood obesity
Particulate matter
topic Air pollution
Prenatal exposure
Childhood growth
Childhood obesity
Particulate matter
description Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003–2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnancy was associated with decreased z-scores of weight (zWeight) and BMI (zBMI) (zWeight change per interquartile range increase in PM2.5 exposure = −0.12; 95% CI: −0.23, −0.01; zBMI change = −0.12; 95% CI: −0.23, −0.01). Higher NO2 and PM2.5 exposure was associated to a reduced risk of being in a trajectory with accelerated BMI gain, compared to children with the average trajectory. Birth weight partially mediated the association between PM2.5 and zWeight and zBMI. PM2.5 and NO2 were not associated with the other cardio-metabolic risk factors. Conclusions: This comprehensive study of many growth and cardio-metabolic risk related outcomes suggests that air pollution exposure during pregnancy may be associated with delays in physical growth in the early years after birth. These findings imply that pregnancy exposure to air pollutants has a lasting effect on growth after birth and require follow-up at later child ages.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/44235
http://dx.doi.org/10.1016/j.envint.2020.105619
url http://hdl.handle.net/10230/44235
http://dx.doi.org/10.1016/j.envint.2020.105619
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environ Int. 2020; 138:105619
info:eu-repo/grantAgreement/EC/FP7/211250
info:eu-repo/grantAgreement/EC/FP7/282957
info:eu-repo/grantAgreement/EC/FP7/308333
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420130152218624
spelling Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolersFossati, SerenaValvi, Damaskini, 1983-Martínez, DavidCirach, MartaEstarlich, MarisaFernández-Somoano, AnaGuxens Junyent, MònicaIñiguez, CarmenIrizar, AmaiaLertxundi, AitanaNieuwenhuijsen, Mark J.Tamayo-Uria, IbonVioque, JesusTardón, AdoninaSunyer Deu, JordiVrijheid, MartineAir pollutionPrenatal exposureChildhood growthChildhood obesityParticulate matterObjectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003–2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnancy was associated with decreased z-scores of weight (zWeight) and BMI (zBMI) (zWeight change per interquartile range increase in PM2.5 exposure = −0.12; 95% CI: −0.23, −0.01; zBMI change = −0.12; 95% CI: −0.23, −0.01). Higher NO2 and PM2.5 exposure was associated to a reduced risk of being in a trajectory with accelerated BMI gain, compared to children with the average trajectory. Birth weight partially mediated the association between PM2.5 and zWeight and zBMI. PM2.5 and NO2 were not associated with the other cardio-metabolic risk factors. Conclusions: This comprehensive study of many growth and cardio-metabolic risk related outcomes suggests that air pollution exposure during pregnancy may be associated with delays in physical growth in the early years after birth. These findings imply that pregnancy exposure to air pollutants has a lasting effect on growth after birth and require follow-up at later child ages.This study was funded by grants from the Eulji University (grant numbers ESCAPE project FP7-ENV-2007-1-211250, DENAMIC project FP7-ENV-2011-282957, HELIX project FP7-ENV-2012-308333, and MEDALL project HEALTH.2010.2.4.5-1), from the Spanish Instituto de Salud Carlos III (grant numbers Red INMA G03/176; CB06/02/0041; PI03/1615 incl. FEDER funds, PI04/1112 incl. FEDER funds, PI041436, PI04/1509 incl. FEDER funds, PI04/1931 incl. FEDER funds, PI042018 incl. FEDER funds, PI05/1079 incl. FEDER funds, PI05/1052 incl. FEDER funds, FIS-PI06/0867, PI06/1213 incl. FEDER funds, PI07/0314 incl. FEDER funds, PI081151 incl. FEDER funds, FIS-PI09/00090, PI09/02311 incl. FEDER funds, PI09/02647 incl. FEDER funds, PI11/01007 incl. FEDER funds, PI11/02591 incl. FEDER funds, PI11/02038 incl. FEDER funds, PI13/1944 incl. FEDER funds, PI13/2032 incl. FEDER funds, PI13/02429 incl. FEDER funds, PI14/00891 incl. FEDER funds, PI14/01687 incl. FEDER funds, PI15/00118 incl. FEDER funds, PI16/1288 incl. FEDER funds, and PI17/00663 incl. FEDER funds, PI18/00547 incl. FEDER funds, PI18/00909 incl. FEDER funds; CP11/00178 , CP15/00025, and CPII16/00051; MS13/00054 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (grant numbers 2005111093, 2013111089), Generalitat de Catalunya-CIRIT (grant numbers 1999SGR 00241), Generalitat Valenciana: FISABIO (grant numbers UGP 15-230, UGP-15-244, and UGP-15-249), Provincial Government of Gipuzkoa (grant number DFG06/002), Alicia Koplowitz Foundation 2017, Fundació La marató de TV3 (grant number 090430), Obra Social Cajastur/Fundación Liberbank, Universidad de Oviedo, and annual agreements with the municipalities of the study area of the Gipuzkoa sub-cohort (Zumarraga, Urretxu , Legazpi, Azkoitia, Azpeitia and Beasain). ISGlobal is a member of the Agency for the Research Centres of Catalonia (CERCA) Programme, Generalitat de Catalunya.Elsevier202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/44235http://dx.doi.org/10.1016/j.envint.2020.105619reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnviron Int. 2020; 138:105619info:eu-repo/grantAgreement/EC/FP7/211250info:eu-repo/grantAgreement/EC/FP7/282957info:eu-repo/grantAgreement/EC/FP7/308333© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/442352026-06-12T07:21:37Z
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