Heat stress-induced mitochondrial damage and its impact on leukocyte function

Cell death; Heat stress; Leukocyte

Detalles Bibliográficos
Autores: Helms, Julie, Iba, Toshiaki, Nagaoka, Isao, Ferrer, Ricard, Levy, Jerrold
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::77f2581a2139534a18aee1a31cd70280
Acceso en línea:http://hdl.handle.net/11351/14686
https://hdl.handle.net/11351/14686
Access Level:acceso abierto
Palabra clave:Apoptosi
Inflamació
Mitocondris
Calor - Efectes fisiològics
PHENOMENA AND PROCESSES::Physiological Phenomena::Stress, Physiological::Heat-Shock Response
ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::estrés fisiológico::respuesta al choque por calor
ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
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dc.title.none.fl_str_mv Heat stress-induced mitochondrial damage and its impact on leukocyte function
title Heat stress-induced mitochondrial damage and its impact on leukocyte function
spellingShingle Heat stress-induced mitochondrial damage and its impact on leukocyte function
Helms, Julie
Apoptosi
Inflamació
Mitocondris
Calor - Efectes fisiològics
PHENOMENA AND PROCESSES::Physiological Phenomena::Stress, Physiological::Heat-Shock Response
ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::estrés fisiológico::respuesta al choque por calor
ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
title_short Heat stress-induced mitochondrial damage and its impact on leukocyte function
title_full Heat stress-induced mitochondrial damage and its impact on leukocyte function
title_fullStr Heat stress-induced mitochondrial damage and its impact on leukocyte function
title_full_unstemmed Heat stress-induced mitochondrial damage and its impact on leukocyte function
title_sort Heat stress-induced mitochondrial damage and its impact on leukocyte function
dc.creator.none.fl_str_mv Helms, Julie
Iba, Toshiaki
Nagaoka, Isao
Ferrer, Ricard
Levy, Jerrold
author Helms, Julie
author_facet Helms, Julie
Iba, Toshiaki
Nagaoka, Isao
Ferrer, Ricard
Levy, Jerrold
author_role author
author2 Iba, Toshiaki
Nagaoka, Isao
Ferrer, Ricard
Levy, Jerrold
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Iba T] Faculty of Medical Science, Juntendo University, 6-8-1 Hinode, Urayasu, Chiba, Japan. [Helms J] Medicine Faculty, Medical Intensive Care Unit NHC, Strasbourg University, University Hospital Federation (FHU) TARGET, Strasbourg University Hospital, Strasbourg, France. INSERM (French National Institute of Health and Medical Research, UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France. [Nagaoka I] Faculty of Medical Science, Juntendo University, 6-8-1 Hinode, Urayasu, Chiba, Japan. [Ferrer R] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Levy JH] Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Apoptosi
Inflamació
Mitocondris
Calor - Efectes fisiològics
PHENOMENA AND PROCESSES::Physiological Phenomena::Stress, Physiological::Heat-Shock Response
ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::estrés fisiológico::respuesta al choque por calor
ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
topic Apoptosi
Inflamació
Mitocondris
Calor - Efectes fisiològics
PHENOMENA AND PROCESSES::Physiological Phenomena::Stress, Physiological::Heat-Shock Response
ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::estrés fisiológico::respuesta al choque por calor
ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
description Cell death; Heat stress; Leukocyte
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11351/14686
https://hdl.handle.net/11351/14686
url http://hdl.handle.net/11351/14686
https://hdl.handle.net/11351/14686
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Intensive Care;13(1)
https://doi.org/10.1186/s40560-025-00832-9
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420126117298176
spelling Heat stress-induced mitochondrial damage and its impact on leukocyte functionHelms, JulieIba, ToshiakiNagaoka, IsaoFerrer, RicardLevy, JerroldApoptosiInflamacióMitocondrisCalor - Efectes fisiològicsPHENOMENA AND PROCESSES::Physiological Phenomena::Stress, Physiological::Heat-Shock ResponseANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::MitochondriaDISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::InflammationPHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::ApoptosisFENÓMENOS Y PROCESOS::fenómenos fisiológicos::estrés fisiológico::respuesta al choque por calorANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondriasENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamaciónFENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosisCell death; Heat stress; LeukocyteMuerte celular; Estrés térmico; LeucocitosMort cel·lular; Estrès tèrmic; LeucòcitsHeatstroke is characterized by systemic inflammation, immune dysregulation, and multiorgan failure, in which mitochondrial damage in leukocytes plays a pivotal role. This review examines the mechanisms by which heat stress induces leukocyte mitochondrial dysfunction and its downstream effects on immunity, coagulation, and organ integrity. Exposure to heat stress activates leukocytes through damage-associated molecular patterns (DAMPs), triggering the release of proinflammatory cytokines, reactive oxygen species (ROS), and neutrophil extracellular traps (NETs). These responses disrupt endothelial integrity, promote microvascular thrombosis, and contribute to the development of disseminated intravascular coagulation (DIC). Prolonged heat exposure further shifts the immune landscape toward immunosuppression, marked by monocyte deactivation and lymphocyte apoptosis. Mitochondrial dysfunction is central to this biphasic immune response. Heat stress reduces mitochondrial membrane potential, increases ROS production, and promotes the release of mitochondrial DNA and cytochrome c, amplifying inflammation and initiating cell death pathways, including apoptosis, pyroptosis, and ferroptosis. Biomarkers such as reduced mitochondrial membrane potential (ΔΨm), elevated mitochondrial ROS, cytochrome c, circulating mitochondrial DNA (mtDNA), and altered expression of mitophagy regulators (e.g., PINK1 and Parkin) provide insights into mitochondrial integrity and function in leukocytes. In addition to immune disruption, mitochondrial injury exacerbates coagulation abnormalities by promoting platelet activation and endothelial dysfunction, fostering a prothrombotic environment. In the microcirculation, leukocyte adhesion, NET formation, and endothelial damage create a self-amplifying cycle of ischemia and inflammation, ultimately leading to organ dysfunction, including hepatic failure, acute kidney injury, acute lung injury, and gastrointestinal barrier breakdown. Therapeutic strategies aimed at preserving mitochondrial function include antioxidants (e.g., N-acetylcysteine and MitoQ), mitochondrial biogenesis inducers (e.g., PGC-1α activators), and mitophagy enhancers. Understanding the central role of leukocyte mitochondrial damage in heat stress provides a foundation for the development of targeted diagnostics and interventions to prevent organ failure and improve clinical outcomes.BMCInstitut Català de la Salut[Iba T] Faculty of Medical Science, Juntendo University, 6-8-1 Hinode, Urayasu, Chiba, Japan. [Helms J] Medicine Faculty, Medical Intensive Care Unit NHC, Strasbourg University, University Hospital Federation (FHU) TARGET, Strasbourg University Hospital, Strasbourg, France. INSERM (French National Institute of Health and Medical Research, UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France. [Nagaoka I] Faculty of Medical Science, Juntendo University, 6-8-1 Hinode, Urayasu, Chiba, Japan. [Ferrer R] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Levy JH] Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USAVall d'Hebron Barcelona Hospital Campus202620262025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/14686https://hdl.handle.net/11351/14686Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Intensive Care;13(1)https://doi.org/10.1186/s40560-025-00832-9Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::77f2581a2139534a18aee1a31cd702802026-05-29T05:05:01Z
score 15,81155

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