Genetic Linkage Studies in Alopecia Areata

25 páginas, 1 figura, 1 tabla. Fourth International Research Workshop on Alopecia Areata. Washington, 31 oct.- 2 nov. 2002.

Detalles Bibliográficos
Autores: Martínez Mir, Amalia, Zlotogorski, Abraham, Ott, Jurg, Gordon, Derek, Christiano, Angela M.
Tipo de recurso: artículo
Fecha de publicación:2003
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/39512
Acceso en línea:http://hdl.handle.net/10261/39512
Access Level:acceso abierto
Palabra clave:Alopecia areata
Complex inheritance
Alopecia totalis (AT)
Alopecia universalis (AU)
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spelling Genetic Linkage Studies in Alopecia AreataMartínez Mir, AmaliaZlotogorski, AbrahamOtt, JurgGordon, DerekChristiano, Angela M.Alopecia areataComplex inheritanceAlopecia totalis (AT)Alopecia universalis (AU)25 páginas, 1 figura, 1 tabla. Fourth International Research Workshop on Alopecia Areata. Washington, 31 oct.- 2 nov. 2002.Alopecia areata affects approximately 4.6 million individuals in the United States alone. It is typified by patchy hair loss on the scalp that can progress to cover the entire scalp (alopecia totalis) and eventually the entire body (alopecia universalis). Despite the high incidence of this condition, its genetic basis is largely unknown. It is now generally accepted, however, that it fits the paradigm of a complex trait, in which a combination of genetic and environmental factors results in the final phenotype. Genetic studies have been limited thus far to association analyses, which suggest that a permissive HLA status may potentiate the development of alopecia areata. A systematic screen for identifying the primary genetic mechanisms underlying this disorder has never before been undertaken, however. Here we discuss our approach to the identification of susceptibility genes for alopecia areata. In particular, we recently initiated a comprehensive genetic analysis by performing a genome-wide scan in a collection of alopecia families with multiple affected family members. There are currently a number of examples of complex diseases of the skin, such as psoriasis and atopic dermatitis, in which genetic studies are being undertaken that substantiate the timeliness of this approach. We anticipate that these studies will lead to the identification of the susceptibility genes and provide a foundation for understanding how they interact with each other and with other variables, such as the immune system and environmental factors.This study was supported in part by grants from the National Alopecia Areata Foundation (AMC and AZ), by the General Administrator, Israel (AZ), and NIH grants N01-AR-0–2249 (NIH AA Registry), K01-HG00055 (DG), MH59492 (JO), and HG00008 (JO).Peer reviewedSociety for Investigative Dermatology201120112003info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/39512reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1046/j.1087-0024.2003.00809.xinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/395122026-05-22T06:33:51Z
dc.title.none.fl_str_mv Genetic Linkage Studies in Alopecia Areata
title Genetic Linkage Studies in Alopecia Areata
spellingShingle Genetic Linkage Studies in Alopecia Areata
Martínez Mir, Amalia
Alopecia areata
Complex inheritance
Alopecia totalis (AT)
Alopecia universalis (AU)
title_short Genetic Linkage Studies in Alopecia Areata
title_full Genetic Linkage Studies in Alopecia Areata
title_fullStr Genetic Linkage Studies in Alopecia Areata
title_full_unstemmed Genetic Linkage Studies in Alopecia Areata
title_sort Genetic Linkage Studies in Alopecia Areata
dc.creator.none.fl_str_mv Martínez Mir, Amalia
Zlotogorski, Abraham
Ott, Jurg
Gordon, Derek
Christiano, Angela M.
author Martínez Mir, Amalia
author_facet Martínez Mir, Amalia
Zlotogorski, Abraham
Ott, Jurg
Gordon, Derek
Christiano, Angela M.
author_role author
author2 Zlotogorski, Abraham
Ott, Jurg
Gordon, Derek
Christiano, Angela M.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Alopecia areata
Complex inheritance
Alopecia totalis (AT)
Alopecia universalis (AU)
topic Alopecia areata
Complex inheritance
Alopecia totalis (AT)
Alopecia universalis (AU)
description 25 páginas, 1 figura, 1 tabla. Fourth International Research Workshop on Alopecia Areata. Washington, 31 oct.- 2 nov. 2002.
publishDate 2003
dc.date.none.fl_str_mv 2003
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/39512
url http://hdl.handle.net/10261/39512
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1046/j.1087-0024.2003.00809.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Society for Investigative Dermatology
publisher.none.fl_str_mv Society for Investigative Dermatology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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