Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis
Adipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was to evaluate the association between adipokines in synovial fluid and clinical severity in patients with knee osteoarthritis with joint effusion. Cross-sectional study with systematic incl...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:185982 |
| Acceso en línea: | https://ddd.uab.cat/record/185982 https://dx.doi.org/urn:doi:10.1186/s13075-016-1103-1 |
| Access Level: | acceso abierto |
| Palabra clave: | Knee osteoarthritis Adipokines Inflammation Synovial fluid Clinical severity |
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Synovial fluid adipokines are associated with clinical severity in knee osteoarthritisa cross-sectional study in female patients with joint effusionCalvet, Joan|||0000-0002-0888-5152Orellana, CristóbalGratacós, Jordi|||0000-0003-4007-4103Berenguer-Llergo, Antoni|||0000-0002-3742-8161Caixàs i Pedragós, Assumpta|||0000-0001-8472-9189Chillaron, Juan Jose|||0000-0002-8096-1703Pedro Botet Montoya, Juan|||0000-0001-7366-6821García-Manrique, MaríaNavarro, NoemíLarrosa, Marta|||0000-0001-9891-4561Knee osteoarthritisAdipokinesInflammationSynovial fluidClinical severityAdipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was to evaluate the association between adipokines in synovial fluid and clinical severity in patients with knee osteoarthritis with joint effusion. Cross-sectional study with systematic inclusion of female patients with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, physical exercise, knee osteoarthritis symptoms duration, classical cardiovascular risk factors and different anthropometric measurements were collected. Metabolic syndrome was defined in accordance to National Cholesterol Education Program-Adult Treatment Panel III. Radiographic severity was evaluated according to Kellgren-Lawrence scale and Lequesne index was used to assess clinical severity. Seven adipokines (leptin, adiponectin, resistin, visfatin, osteopontin, omentin and chemerin) and three inflammatory markers (tumor necrosis factor α, interleukin 6 and high sensitivity C-reactive protein) were measured by enzyme-linked immunosorbent assay in synovial fluid. Kellgren-Lawrence grade, physical exercise, all anthropometric measurements (especially waist circumference), tumor necrosis factor α, and high levels of leptin, resistin, and ostepontin were related to knee osteoarthritis severity. After adjustment for clinical confounders (age, symptom duration, and radiology), anthropometric measurements, inflammatory markers, and all evaluated adipokines, there were independent associations with clinical severity for resistin (directly associated) and visfatin (inversely associated). No other adipokines or inflammatory markers were independently associated with Lequesne index. The association of radiological parameters, physical exercise, and waist circumference with Lequesne index remained after adjustment. Resistin was directly associated, and visfatin was inversely associated, with clinical severity in female patients with knee osteoarthritis with joint effusion. These associations were more important after adjustment for confounders, especially when all adipokines were evaluated. The online version of this article (doi:10.1186/s13075-016-1103-1) contains supplementary material, which is available to authorized users. 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/185982https://dx.doi.org/urn:doi:10.1186/s13075-016-1103-1reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1859822026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis a cross-sectional study in female patients with joint effusion |
| title |
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis |
| spellingShingle |
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis Calvet, Joan|||0000-0002-0888-5152 Knee osteoarthritis Adipokines Inflammation Synovial fluid Clinical severity |
| title_short |
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis |
| title_full |
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis |
| title_fullStr |
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis |
| title_full_unstemmed |
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis |
| title_sort |
Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis |
| dc.creator.none.fl_str_mv |
Calvet, Joan|||0000-0002-0888-5152 Orellana, Cristóbal Gratacós, Jordi|||0000-0003-4007-4103 Berenguer-Llergo, Antoni|||0000-0002-3742-8161 Caixàs i Pedragós, Assumpta|||0000-0001-8472-9189 Chillaron, Juan Jose|||0000-0002-8096-1703 Pedro Botet Montoya, Juan|||0000-0001-7366-6821 García-Manrique, María Navarro, Noemí Larrosa, Marta|||0000-0001-9891-4561 |
| author |
Calvet, Joan|||0000-0002-0888-5152 |
| author_facet |
Calvet, Joan|||0000-0002-0888-5152 Orellana, Cristóbal Gratacós, Jordi|||0000-0003-4007-4103 Berenguer-Llergo, Antoni|||0000-0002-3742-8161 Caixàs i Pedragós, Assumpta|||0000-0001-8472-9189 Chillaron, Juan Jose|||0000-0002-8096-1703 Pedro Botet Montoya, Juan|||0000-0001-7366-6821 García-Manrique, María Navarro, Noemí Larrosa, Marta|||0000-0001-9891-4561 |
| author_role |
author |
| author2 |
Orellana, Cristóbal Gratacós, Jordi|||0000-0003-4007-4103 Berenguer-Llergo, Antoni|||0000-0002-3742-8161 Caixàs i Pedragós, Assumpta|||0000-0001-8472-9189 Chillaron, Juan Jose|||0000-0002-8096-1703 Pedro Botet Montoya, Juan|||0000-0001-7366-6821 García-Manrique, María Navarro, Noemí Larrosa, Marta|||0000-0001-9891-4561 |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Knee osteoarthritis Adipokines Inflammation Synovial fluid Clinical severity |
| topic |
Knee osteoarthritis Adipokines Inflammation Synovial fluid Clinical severity |
| description |
Adipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was to evaluate the association between adipokines in synovial fluid and clinical severity in patients with knee osteoarthritis with joint effusion. Cross-sectional study with systematic inclusion of female patients with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, physical exercise, knee osteoarthritis symptoms duration, classical cardiovascular risk factors and different anthropometric measurements were collected. Metabolic syndrome was defined in accordance to National Cholesterol Education Program-Adult Treatment Panel III. Radiographic severity was evaluated according to Kellgren-Lawrence scale and Lequesne index was used to assess clinical severity. Seven adipokines (leptin, adiponectin, resistin, visfatin, osteopontin, omentin and chemerin) and three inflammatory markers (tumor necrosis factor α, interleukin 6 and high sensitivity C-reactive protein) were measured by enzyme-linked immunosorbent assay in synovial fluid. Kellgren-Lawrence grade, physical exercise, all anthropometric measurements (especially waist circumference), tumor necrosis factor α, and high levels of leptin, resistin, and ostepontin were related to knee osteoarthritis severity. After adjustment for clinical confounders (age, symptom duration, and radiology), anthropometric measurements, inflammatory markers, and all evaluated adipokines, there were independent associations with clinical severity for resistin (directly associated) and visfatin (inversely associated). No other adipokines or inflammatory markers were independently associated with Lequesne index. The association of radiological parameters, physical exercise, and waist circumference with Lequesne index remained after adjustment. Resistin was directly associated, and visfatin was inversely associated, with clinical severity in female patients with knee osteoarthritis with joint effusion. These associations were more important after adjustment for confounders, especially when all adipokines were evaluated. The online version of this article (doi:10.1186/s13075-016-1103-1) contains supplementary material, which is available to authorized users. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2 2016-01-01 2016 2016-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/185982 https://dx.doi.org/urn:doi:10.1186/s13075-016-1103-1 |
| url |
https://ddd.uab.cat/record/185982 https://dx.doi.org/urn:doi:10.1186/s13075-016-1103-1 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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