Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial

Roig-Coll, Francesca; Castells Sánchez, Alba; Monté Rubio, Gemma C.; Dacosta-Aguayo, Rosalia; Lamonja-Vicente, Noemí; Torán Monserrat, Pere; Pere, Guillem; García Molina, Alberto; Tormos, José María; Alzamora, María Teresa; Stavros, Dimitriadis; Sánchez‑Ceron, Marta; Via i García, Marc; Erickson, Kirk I.; Mataró Serrat, Maria

Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial

Introduction: This is a 12-weeks randomized controlled trial examining the effects of aerobic exercise (AE), computerized cognitive training (CCT) and their combination (COMB). We aim to investigate their impact on cardiovascular health and white matter (WM) integrity and how they contribute to the...

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Autores:	Roig-Coll, Francesca, Castells Sánchez, Alba, Monté Rubio, Gemma C., Dacosta-Aguayo, Rosalia, Lamonja-Vicente, Noemí, Torán Monserrat, Pere, Pere, Guillem, García Molina, Alberto, Tormos, José María, Alzamora, María Teresa, Stavros, Dimitriadis, Sánchez‑Ceron, Marta, Via i García, Marc, Erickson, Kirk I., Mataró Serrat, Maria
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2024
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/220067
Acceso en línea:	https://hdl.handle.net/2445/220067
Access Level:	acceso abierto
Palabra clave:	Aeròbic Adults Sistema cardiovascular Neurologia Cognició Exercici Aerobic Adulthood Cardiovascular system Neurology Cognition Exercise

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spelling	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trialRoig-Coll, FrancescaCastells Sánchez, AlbaMonté Rubio, Gemma C.Dacosta-Aguayo, RosaliaLamonja-Vicente, NoemíTorán Monserrat, PerePere, GuillemGarcía Molina, AlbertoTormos, José MaríaAlzamora, María TeresaStavros, DimitriadisSánchez‑Ceron, MartaVia i García, MarcErickson, Kirk I.Mataró Serrat, MariaAeròbicAdultsSistema cardiovascularNeurologiaCognicióExerciciAerobicAdulthoodCardiovascular systemNeurologyCognitionExerciseIntroduction: This is a 12-weeks randomized controlled trial examining the effects of aerobic exercise (AE), computerized cognitive training (CCT) and their combination (COMB). We aim to investigate their impact on cardiovascular health and white matter (WM) integrity and how they contribute to the cognitive benefits. Methods: 109 participants were recruited and 82 (62% female; age = 58.38 ± 5.47) finished the intervention with > 80% adherence. We report changes in cardiovascular risk factors and WM integrity (fractional anisotropy (FA); mean diffusivity (MD)), how they might be related to changes in physical activity, age and sex, and their potential role as mediators in cognitive improvements. Results: A decrease in BMI (SMD = − 0.32, p = 0.039), waist circumference (SMD = − 0.42, p = 0.003) and diastolic blood pressure (DBP) (SMD = − 0.42, p = 0.006) in the AE group and a decrease in BMI (SMD = − 0.34, p = 0.031) and DBP (SMD = − 0.32, p = 0.034) in the COMB group compared to the waitlist control group was observed. We also found decreased global MD in the CCT group (SMD = − 0.34; p = 0.032) and significant intervention-related changes in FA and MD in the frontal and temporal lobes in the COMB group. Conclusions: We found changes in anthropometric measures that suggest initial benefits on cardiovascular health after only 12 weeks of AE and changes in WM microstructure in the CCT and COMB groups. These results add evidence of the clinical relevance of lifestyle interventions and the potential benefits when combining them.Springer Verlag2025202520242025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfhttps://hdl.handle.net/2445/220067Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s00421-023-05319-9European Journal of Applied Physiology, 2024, vol. 124, p. 909-924https://doi.org/10.1007/s00421-023-05319-9cc by (c) Roig-Coll, Francesca et al., 2024https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2200672026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial
title	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial
spellingShingle	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial Roig-Coll, Francesca Aeròbic Adults Sistema cardiovascular Neurologia Cognició Exercici Aerobic Adulthood Cardiovascular system Neurology Cognition Exercise
title_short	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial
title_full	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial
title_fullStr	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial
title_full_unstemmed	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial
title_sort	Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial
dc.creator.none.fl_str_mv	Roig-Coll, Francesca Castells Sánchez, Alba Monté Rubio, Gemma C. Dacosta-Aguayo, Rosalia Lamonja-Vicente, Noemí Torán Monserrat, Pere Pere, Guillem García Molina, Alberto Tormos, José María Alzamora, María Teresa Stavros, Dimitriadis Sánchez‑Ceron, Marta Via i García, Marc Erickson, Kirk I. Mataró Serrat, Maria
author	Roig-Coll, Francesca
author_facet	Roig-Coll, Francesca Castells Sánchez, Alba Monté Rubio, Gemma C. Dacosta-Aguayo, Rosalia Lamonja-Vicente, Noemí Torán Monserrat, Pere Pere, Guillem García Molina, Alberto Tormos, José María Alzamora, María Teresa Stavros, Dimitriadis Sánchez‑Ceron, Marta Via i García, Marc Erickson, Kirk I. Mataró Serrat, Maria
author_role	author
author2	Castells Sánchez, Alba Monté Rubio, Gemma C. Dacosta-Aguayo, Rosalia Lamonja-Vicente, Noemí Torán Monserrat, Pere Pere, Guillem García Molina, Alberto Tormos, José María Alzamora, María Teresa Stavros, Dimitriadis Sánchez‑Ceron, Marta Via i García, Marc Erickson, Kirk I. Mataró Serrat, Maria
author2_role	author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Aeròbic Adults Sistema cardiovascular Neurologia Cognició Exercici Aerobic Adulthood Cardiovascular system Neurology Cognition Exercise
topic	Aeròbic Adults Sistema cardiovascular Neurologia Cognició Exercici Aerobic Adulthood Cardiovascular system Neurology Cognition Exercise
description	Introduction: This is a 12-weeks randomized controlled trial examining the effects of aerobic exercise (AE), computerized cognitive training (CCT) and their combination (COMB). We aim to investigate their impact on cardiovascular health and white matter (WM) integrity and how they contribute to the cognitive benefits. Methods: 109 participants were recruited and 82 (62% female; age = 58.38 ± 5.47) finished the intervention with > 80% adherence. We report changes in cardiovascular risk factors and WM integrity (fractional anisotropy (FA); mean diffusivity (MD)), how they might be related to changes in physical activity, age and sex, and their potential role as mediators in cognitive improvements. Results: A decrease in BMI (SMD = − 0.32, p = 0.039), waist circumference (SMD = − 0.42, p = 0.003) and diastolic blood pressure (DBP) (SMD = − 0.42, p = 0.006) in the AE group and a decrease in BMI (SMD = − 0.34, p = 0.031) and DBP (SMD = − 0.32, p = 0.034) in the COMB group compared to the waitlist control group was observed. We also found decreased global MD in the CCT group (SMD = − 0.34; p = 0.032) and significant intervention-related changes in FA and MD in the frontal and temporal lobes in the COMB group. Conclusions: We found changes in anthropometric measures that suggest initial benefits on cardiovascular health after only 12 weeks of AE and changes in WM microstructure in the CCT and COMB groups. These results add evidence of the clinical relevance of lifestyle interventions and the potential benefits when combining them.
publishDate	2024
dc.date.none.fl_str_mv	2024 2025 2025 2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/220067
url	https://hdl.handle.net/2445/220067
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1007/s00421-023-05319-9 European Journal of Applied Physiology, 2024, vol. 124, p. 909-924 https://doi.org/10.1007/s00421-023-05319-9
dc.rights.none.fl_str_mv	cc by (c) Roig-Coll, Francesca et al., 2024 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Roig-Coll, Francesca et al., 2024 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	16 p. application/pdf
dc.publisher.none.fl_str_mv	Springer Verlag
publisher.none.fl_str_mv	Springer Verlag
dc.source.none.fl_str_mv	Articles publicats en revistes (Psicologia Clínica i Psicobiologia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial

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