GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists

Type 2 diabetes mellitus (T2DM) represents the main cause of chronic kidney disease (CKD) and end-stage renal disease (ESKD), and diabetic kidney disease (DKD) is a major cause of morbidity and mortality in diabetes. Despite advances in the nephroprotective treatment of T2DM, DKD remains the most co...

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Autores: Górriz, José Luis, Soler, María José, Navarro-González, Juan F., García-Carro, Clara, Puchades, María Jesús, D’Marco, Luis, Martínez Castelao, Alberto, Fernández Fernández, Beatriz, Ortiz Arduán, Alberto, Górriz-Zambrano, Carmen, Navarro-Pérez, Jorge, Gorgojo-Martinez, Juan José
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/694091
Acceso en línea:http://hdl.handle.net/10486/694091
https://dx.doi.org/10.3390/jcm9040947
Access Level:acceso abierto
Palabra clave:Chronic kidney disease
Diabetic kidney disease
GLP-1
Medicina
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repository_id_str
spelling GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologistsGórriz, José LuisSoler, María JoséNavarro-González, Juan F.García-Carro, ClaraPuchades, María JesúsD’Marco, LuisMartínez Castelao, AlbertoFernández Fernández, BeatrizOrtiz Arduán, AlbertoGórriz-Zambrano, CarmenNavarro-Pérez, JorgeGorgojo-Martinez, Juan JoséChronic kidney diseaseDiabetic kidney diseaseGLP-1MedicinaType 2 diabetes mellitus (T2DM) represents the main cause of chronic kidney disease (CKD) and end-stage renal disease (ESKD), and diabetic kidney disease (DKD) is a major cause of morbidity and mortality in diabetes. Despite advances in the nephroprotective treatment of T2DM, DKD remains the most common complication, driving the need for renal replacement therapies (RRT) worldwide, and its incidence is increasing. Until recently, prevention of DKD progression was based around strict blood pressure (BP) control, using renin–angiotensin system blockers that simultaneously reduce BP and proteinuria, adequate glycemic control and control of cardiovascular risk factors. Glucagon-like peptide-1 receptor agonists (GLP-1RA) are a new class of anti-hyperglycemic drugs shown to improve cardiovascular and renal events in DKD. In this regard, GLP-1RA o er the potential for adequate glycemic control in multiple stages of DKD without an increased risk of hypoglycemia, preventing the onset of macroalbuminuria and slowing the decline of glomerular filtration rate (GFR) in diabetic patients, also bringing additional benefit in weight reduction, cardiovascular and other kidney outcomes. Results from ongoing trials are pending to assess the impact of GLP-1RA treatments on primary kidney endpoints in DKDMDPI, Basel, SMwitzerlandDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)20202020-03-30research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/694091https://dx.doi.org/10.3390/jcm9040947reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6940912026-06-23T12:46:27Z
dc.title.none.fl_str_mv GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
title GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
spellingShingle GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
Górriz, José Luis
Chronic kidney disease
Diabetic kidney disease
GLP-1
Medicina
title_short GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
title_full GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
title_fullStr GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
title_full_unstemmed GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
title_sort GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
dc.creator.none.fl_str_mv Górriz, José Luis
Soler, María José
Navarro-González, Juan F.
García-Carro, Clara
Puchades, María Jesús
D’Marco, Luis
Martínez Castelao, Alberto
Fernández Fernández, Beatriz
Ortiz Arduán, Alberto
Górriz-Zambrano, Carmen
Navarro-Pérez, Jorge
Gorgojo-Martinez, Juan José
author Górriz, José Luis
author_facet Górriz, José Luis
Soler, María José
Navarro-González, Juan F.
García-Carro, Clara
Puchades, María Jesús
D’Marco, Luis
Martínez Castelao, Alberto
Fernández Fernández, Beatriz
Ortiz Arduán, Alberto
Górriz-Zambrano, Carmen
Navarro-Pérez, Jorge
Gorgojo-Martinez, Juan José
author_role author
author2 Soler, María José
Navarro-González, Juan F.
García-Carro, Clara
Puchades, María Jesús
D’Marco, Luis
Martínez Castelao, Alberto
Fernández Fernández, Beatriz
Ortiz Arduán, Alberto
Górriz-Zambrano, Carmen
Navarro-Pérez, Jorge
Gorgojo-Martinez, Juan José
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
dc.subject.none.fl_str_mv Chronic kidney disease
Diabetic kidney disease
GLP-1
Medicina
topic Chronic kidney disease
Diabetic kidney disease
GLP-1
Medicina
description Type 2 diabetes mellitus (T2DM) represents the main cause of chronic kidney disease (CKD) and end-stage renal disease (ESKD), and diabetic kidney disease (DKD) is a major cause of morbidity and mortality in diabetes. Despite advances in the nephroprotective treatment of T2DM, DKD remains the most common complication, driving the need for renal replacement therapies (RRT) worldwide, and its incidence is increasing. Until recently, prevention of DKD progression was based around strict blood pressure (BP) control, using renin–angiotensin system blockers that simultaneously reduce BP and proteinuria, adequate glycemic control and control of cardiovascular risk factors. Glucagon-like peptide-1 receptor agonists (GLP-1RA) are a new class of anti-hyperglycemic drugs shown to improve cardiovascular and renal events in DKD. In this regard, GLP-1RA o er the potential for adequate glycemic control in multiple stages of DKD without an increased risk of hypoglycemia, preventing the onset of macroalbuminuria and slowing the decline of glomerular filtration rate (GFR) in diabetic patients, also bringing additional benefit in weight reduction, cardiovascular and other kidney outcomes. Results from ongoing trials are pending to assess the impact of GLP-1RA treatments on primary kidney endpoints in DKD
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-03-30
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/694091
https://dx.doi.org/10.3390/jcm9040947
url http://hdl.handle.net/10486/694091
https://dx.doi.org/10.3390/jcm9040947
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI, Basel, SMwitzerland
publisher.none.fl_str_mv MDPI, Basel, SMwitzerland
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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