Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime

[EN] We report experimental results of label-free anti-bovine serum albumin (anti-BSA) antibody detection using a SOI planar photonic crystal waveguide previously bio-functionalized with complementary BSA antigen probes. Sharp fringes appearing in the slow-light regime near the edge of the guided ba...

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Detalhes bibliográficos
Autores: García-Rupérez, Jaime|||0000-0002-2036-0084, Bañuls Polo, María-José|||0000-0002-2422-7731, Griol Barres, Amadeu, Maquieira, Angel|||0000-0003-4641-4957, Toccafondo, Veronica, Garcia Castello, Javier, Peransi-Llopis, Sergio
Formato: artículo
Fecha de publicación:2010
País:España
Recursos:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/231360
Acesso em linha:https://riunet.upv.es/handle/10251/231360
Access Level:acceso abierto
Palavra-chave:Refractive-Index Measurements
Mach-Zehnder Interferometer
Microring Resonator
Microcavity Sensor
Biosensor
Array
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oai_identifier_str oai:riunet.upv.es:10251/231360
network_acronym_str ES
network_name_str España
repository_id_str
spelling Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regimeGarcía-Rupérez, Jaime|||0000-0002-2036-0084Bañuls Polo, María-José|||0000-0002-2422-7731Griol Barres, AmadeuMaquieira, Angel|||0000-0003-4641-4957Toccafondo, VeronicaGarcia Castello, JavierPeransi-Llopis, SergioRefractive-Index MeasurementsMach-Zehnder InterferometerMicroring ResonatorMicrocavity SensorBiosensorArray[EN] We report experimental results of label-free anti-bovine serum albumin (anti-BSA) antibody detection using a SOI planar photonic crystal waveguide previously bio-functionalized with complementary BSA antigen probes. Sharp fringes appearing in the slow-light regime near the edge of the guided band are used to perform the sensing. We have modeled the presence of these band edge fringes and demonstrated the possibility of using them for sensing purposes by performing refractive index variations detection, achieving a sensitivity of 174.8 nm/RIU. Then, label-free anti-BSA biosensing experiments have been carried out, estimating a surface mass density detection limit below 2.1 pg/mm(2) and a total mass detection limit below 0.2 fg.This work was funded by the European Commission, carried out within the FP7-ICT-223932- INTOPSENS project, and by Spanish MICINN under contracts TEC2008-06333 and CTQ2007-64735/BQU. Support from the Universidad Politécnica de Valencia through programs PAID-05-09 and PAID-06-09 and the Conselleria d Educació through program GV2010-031 is also acknowledged.The Optical SocietyEscuela Técnica Superior de Ingeniería de TelecomunicaciónDepartamento de ComunicacionesDepartamento de QuímicaInstituto Universitario de Tecnología NanofotónicaInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo TecnológicoEscuela Técnica Superior de Ingeniería Agronómica y del Medio NaturalEuropean CommissionGeneralitat ValencianaMinisterio de Educación y CienciaMinisterio de Ciencia e InnovaciónUniversitat Politècnica de ValènciaRepositorio Institucional de la Universitat Politècnica de València Riunet20102010-11-08journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/231360reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengEuropean Commission https://doi.org/10.13039/501100000780 FP7 223932 A highly integrated optical sensor for point of care label free identification of pathogenic bacteria strains and their antibiotic resistance.Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 CTQ2007-64735 ESTRATEGIAS PARA EL DESARROLLO DE MICROSISTEMAS ANALITICOS DE BARRIDO BASADOS EN RECEPTORES BIOMOLECULARES Y SU APLICACION A LAS CIENCIAS DE LA VIDAMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 TEC2008-06333 DISPOSITIVOS NANOFOTONICOS EN SILICIOUniversitat Politècnica de València https://doi.org/10.13039/501100004233 PAID-06-09Universitat Politècnica de València https://doi.org/10.13039/501100004233 PAID-05-09Generalitat Valenciana https://doi.org/10.13039/501100003359 GV-2010-031open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2313602026-06-13T07:49:27Z
dc.title.none.fl_str_mv Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
title Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
spellingShingle Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
García-Rupérez, Jaime|||0000-0002-2036-0084
Refractive-Index Measurements
Mach-Zehnder Interferometer
Microring Resonator
Microcavity Sensor
Biosensor
Array
title_short Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
title_full Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
title_fullStr Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
title_full_unstemmed Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
title_sort Label-free antibody detection using band edge fringes in SOI planar photonic crystal waveguides in the slow-light regime
dc.creator.none.fl_str_mv García-Rupérez, Jaime|||0000-0002-2036-0084
Bañuls Polo, María-José|||0000-0002-2422-7731
Griol Barres, Amadeu
Maquieira, Angel|||0000-0003-4641-4957
Toccafondo, Veronica
Garcia Castello, Javier
Peransi-Llopis, Sergio
author García-Rupérez, Jaime|||0000-0002-2036-0084
author_facet García-Rupérez, Jaime|||0000-0002-2036-0084
Bañuls Polo, María-José|||0000-0002-2422-7731
Griol Barres, Amadeu
Maquieira, Angel|||0000-0003-4641-4957
Toccafondo, Veronica
Garcia Castello, Javier
Peransi-Llopis, Sergio
author_role author
author2 Bañuls Polo, María-José|||0000-0002-2422-7731
Griol Barres, Amadeu
Maquieira, Angel|||0000-0003-4641-4957
Toccafondo, Veronica
Garcia Castello, Javier
Peransi-Llopis, Sergio
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escuela Técnica Superior de Ingeniería de Telecomunicación
Departamento de Comunicaciones
Departamento de Química
Instituto Universitario de Tecnología Nanofotónica
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico
Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural
European Commission
Generalitat Valenciana
Ministerio de Educación y Ciencia
Ministerio de Ciencia e Innovación
Universitat Politècnica de València
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Refractive-Index Measurements
Mach-Zehnder Interferometer
Microring Resonator
Microcavity Sensor
Biosensor
Array
topic Refractive-Index Measurements
Mach-Zehnder Interferometer
Microring Resonator
Microcavity Sensor
Biosensor
Array
description [EN] We report experimental results of label-free anti-bovine serum albumin (anti-BSA) antibody detection using a SOI planar photonic crystal waveguide previously bio-functionalized with complementary BSA antigen probes. Sharp fringes appearing in the slow-light regime near the edge of the guided band are used to perform the sensing. We have modeled the presence of these band edge fringes and demonstrated the possibility of using them for sensing purposes by performing refractive index variations detection, achieving a sensitivity of 174.8 nm/RIU. Then, label-free anti-BSA biosensing experiments have been carried out, estimating a surface mass density detection limit below 2.1 pg/mm(2) and a total mass detection limit below 0.2 fg.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-11-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/231360
url https://riunet.upv.es/handle/10251/231360
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 FP7 223932 A highly integrated optical sensor for point of care label free identification of pathogenic bacteria strains and their antibiotic resistance.
Ministerio de Educación y Ciencia https://doi.org/10.13039/501100008743 CTQ2007-64735 ESTRATEGIAS PARA EL DESARROLLO DE MICROSISTEMAS ANALITICOS DE BARRIDO BASADOS EN RECEPTORES BIOMOLECULARES Y SU APLICACION A LAS CIENCIAS DE LA VIDA
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 TEC2008-06333 DISPOSITIVOS NANOFOTONICOS EN SILICIO
Universitat Politècnica de València https://doi.org/10.13039/501100004233 PAID-06-09
Universitat Politècnica de València https://doi.org/10.13039/501100004233 PAID-05-09
Generalitat Valenciana https://doi.org/10.13039/501100003359 GV-2010-031
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Optical Society
publisher.none.fl_str_mv The Optical Society
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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