Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of appetite and metabolism, has previously been reported to influence glial structural proteins and morphol...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2012 |
| País: | España |
| Recursos: | Universidad Autónoma de Madrid |
| Repositório: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.uam.es:10486/663790 |
| Acesso em linha: | http://hdl.handle.net/10486/663790 https://dx.doi.org/10.1172/JCI64102 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Amino Acid Transport System X-AG Astrocytes Hypothalamus Obesity Pro-Opiomelanocortin Medicina |
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Leptin regulates glutamate and glucose transporters in hypothalamic astrocytesFuente-Martín, EstherGarcía-Cáceres, CristinaGranado García, MiriamLópez de Ceballos, MaríaSánchez-Garrido, Miguel ÁngelSármán, BeatrixLiu, ZhongwuDietrich, Marcelo O.Tena-Sempere, ManuelArgente-Arizón, PilarDíaz, FranciscaArgente Oliver, JesúsHorváth, Tamás L.Chowen, Julie AnnAmino Acid Transport System X-AGAstrocytesHypothalamusObesityPro-OpiomelanocortinMedicinaGlial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of appetite and metabolism, has previously been reported to influence glial structural proteins and morphology. Here, we demonstrate that metabolic status and leptin also modify astrocyte-specific glutamate and glucose transporters, indicating that metabolic signals influence synaptic efficacy and glucose uptake and, ultimately, neuronal function. We found that basal and glucose-stimulated electrical activity of hypothalamic proopiomelanocortin (POMC) neurons in mice were altered in the offspring of mothers fed a high-fat diet. In adulthood, increased body weight and fasting also altered the expression of glucose and glutamate transporters. These results demonstrate that whole-organism metabolism alters hypothalamic glial cell activity and suggest that these cells play an important role in the pathology of obesityThis work was supported by grants from the Spanish Government (FIS PI100747, BFU2011-27492, and CIBER de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain). E. Fuente-Martín is supported by a postdoctoral fellowship from CIBERobn. T.L. Horvath was supported by NIH grants DK080000 and DK006850 and an ADA Fellowship grantAmerican Society for Clinical InvestigationDepartamento de FisiologíaDepartamento de PediatríaFacultad de Medicina20122012-11-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/663790https://dx.doi.org/10.1172/JCI64102reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6637902026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes |
| title |
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes |
| spellingShingle |
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes Fuente-Martín, Esther Amino Acid Transport System X-AG Astrocytes Hypothalamus Obesity Pro-Opiomelanocortin Medicina |
| title_short |
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes |
| title_full |
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes |
| title_fullStr |
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes |
| title_full_unstemmed |
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes |
| title_sort |
Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes |
| dc.creator.none.fl_str_mv |
Fuente-Martín, Esther García-Cáceres, Cristina Granado García, Miriam López de Ceballos, María Sánchez-Garrido, Miguel Ángel Sármán, Beatrix Liu, Zhongwu Dietrich, Marcelo O. Tena-Sempere, Manuel Argente-Arizón, Pilar Díaz, Francisca Argente Oliver, Jesús Horváth, Tamás L. Chowen, Julie Ann |
| author |
Fuente-Martín, Esther |
| author_facet |
Fuente-Martín, Esther García-Cáceres, Cristina Granado García, Miriam López de Ceballos, María Sánchez-Garrido, Miguel Ángel Sármán, Beatrix Liu, Zhongwu Dietrich, Marcelo O. Tena-Sempere, Manuel Argente-Arizón, Pilar Díaz, Francisca Argente Oliver, Jesús Horváth, Tamás L. Chowen, Julie Ann |
| author_role |
author |
| author2 |
García-Cáceres, Cristina Granado García, Miriam López de Ceballos, María Sánchez-Garrido, Miguel Ángel Sármán, Beatrix Liu, Zhongwu Dietrich, Marcelo O. Tena-Sempere, Manuel Argente-Arizón, Pilar Díaz, Francisca Argente Oliver, Jesús Horváth, Tamás L. Chowen, Julie Ann |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Fisiología Departamento de Pediatría Facultad de Medicina |
| dc.subject.none.fl_str_mv |
Amino Acid Transport System X-AG Astrocytes Hypothalamus Obesity Pro-Opiomelanocortin Medicina |
| topic |
Amino Acid Transport System X-AG Astrocytes Hypothalamus Obesity Pro-Opiomelanocortin Medicina |
| description |
Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of appetite and metabolism, has previously been reported to influence glial structural proteins and morphology. Here, we demonstrate that metabolic status and leptin also modify astrocyte-specific glutamate and glucose transporters, indicating that metabolic signals influence synaptic efficacy and glucose uptake and, ultimately, neuronal function. We found that basal and glucose-stimulated electrical activity of hypothalamic proopiomelanocortin (POMC) neurons in mice were altered in the offspring of mothers fed a high-fat diet. In adulthood, increased body weight and fasting also altered the expression of glucose and glutamate transporters. These results demonstrate that whole-organism metabolism alters hypothalamic glial cell activity and suggest that these cells play an important role in the pathology of obesity |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2012-11-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/663790 https://dx.doi.org/10.1172/JCI64102 |
| url |
http://hdl.handle.net/10486/663790 https://dx.doi.org/10.1172/JCI64102 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
American Society for Clinical Investigation |
| publisher.none.fl_str_mv |
American Society for Clinical Investigation |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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15,301603 |